公开(公告)号：EP1506184A2

公开(公告)日：2005-02-16

申请号：EP03715125.5

申请日：2003-04-08

申请人： Syngenta Limited ,  Syngenta Participations AG

发明人： JONES, Raymond Vincent Heavon ,  WHITTON, Alan John ,  BENNIE, Colin John ,  RITCHIE, David John ,  BUGNON, Pascal

IPC分类号： C07D311/76

CPC分类号： C07D311/76

摘要： 3-Isochromanone is prepared by partially chlorinating o-tolylacetic acid with sulphuryl chloride or chlorine gas in an inert organic solvent in the presence of a free radical initiator. The 2-chloromethylphenylacetic acid first obtained is converted to 3-isochromanone by treatment with a base and separated from unreacted o-tolylacetic acid, which is in the form of a salt, by a phase separation technique. The separated o-tolylacetic acid salt is converted to o-tolylacetic acid by controlled acidification and the o-tolylacetic acid is extracted for re-use. The invention reduces the formation of unwanted, over-chlorinated by-products and leads to a more efficient process.

公开(公告)号：EP1299359B1

公开(公告)日：2007-06-13

申请号：EP01938443.7

申请日：2001-06-14

申请人： Syngenta Limited

发明人： JONES, Raymond Vincent Heavon ,  STEWART, Alastair Iain Currie ,  WHITTON, Alan John ,  WHITE, Jennifer Ann C/O A J Whitton ,  FORRESTER, Julie ,  MURRAY, Joanne Emma ,  HAMILTON, Susan Thomson

IPC分类号： C07D213/64 ,  C07D215/22 ,  C07D277/68

CPC分类号： C07D213/64 ,  C07D215/227 ,  C07D277/68

摘要： A process for extracting from aqueous solution the alkali metal or calcium salt of a halo or haloalkyl substituted 2-hydroxypyridine, or a 2-hydroxyquinoline or 2-hydroxybenzothiazole which comprises contacting an aqueous alkaline or neutral solution of the alkali metal or calcium salt, in which is dissolved an alkali metal fluoride, chloride, bromide, hydroxide, sulphate, sulphite, cyanate, cyanide, thiocyanate, thiosulphate, sulphide, phosphate, hydrogen phosphate, carbonate, bicarbonate, borate, chlorate, hypochlorite, perchlorate, nitrite, chromate, dichromate or permanganate or calcium chloride, bromide, nitrate, nitrite, chlorate, hypochlorite, perchlorate, thiocyanate, thiosulphate, chromate, dichtromate or permanganate, with a partially water-miscible organic solvent so as to transfer aqueous solution of the alkali metal or calcium salt of the 2-hydroxypyridine, 2-hydroxyquinoline or 2-hydroxybenzothiazole into the solvent whilst retaining separate aqueous and solvent phases, and thereafter separating the solvent phase containing the alkali metal or calcium salt and water from the aqueous phase, the ratio of solvent to water in the separated solvent phase being from 0.5:1 to 10:1 w/w.

公开(公告)号：EP1299359A1

公开(公告)日：2003-04-09

申请号：EP01938443.7

申请日：2001-06-14

申请人： Syngenta Limited

发明人： JONES, Raymond Vincent Heavon ,  STEWART, Alastair Iain Currie ,  WHITTON, Alan John ,  WHITE, Jennifer Ann ,  FORRESTER, Julie ,  MURRAY, Joanne Emma ,  HAMILTON, Susan Thomson

IPC分类号： C07D213/64 ,  C07D215/22 ,  C07D277/68

CPC分类号： C07D213/64 ,  C07D215/227 ,  C07D277/68

摘要： A process for extracting from aqueous solution the alkali metal or calcium salt of a halo or haloalkyl substituted 2-hydroxypyridine, or a 2-hydroxyquinoline or 2-hydroxybenzothiazole which comprises contacting an aqueous alkaline or neutral solution of the alkali metal or calcium salt, in which is dissolved an alkali metal fluoride, chloride, bromide, hydroxide, sulphate, sulphite, cyanate, cyanide, thiocyanate, thiosulphate, sulphide, phosphate, hydrogen phosphate, carbonate, bicarbonate, borate, chlorate, hypochlorite, perchlorate, nitrite, chromate, dichromate or permanganate or calcium chloride, bromide, nitrate, nitrite, chlorate, hypochlorite, perchlorate, thiocyanate, thiosulphate, chromate, dichtromate or permanganate, with a partially water-miscible organic solvent so as to transfer aqueous solution of the alkali metal or calcium salt of the 2-hydroxypyridine, 2-hydroxyquinoline or 2-hydroxybenzothiazole into the solvent whilst retaining separate aqueous and solvent phases, and thereafter separating the solvent phase containing the alkali metal or calcium salt and water from the aqueous phase, the ratio of solvent to water in the separated solvent phase being from 0.5:1 to 10:1 w/w.

公开(公告)号：EP0925285B1

公开(公告)日：2001-10-17

申请号：EP97933760.7

申请日：1997-07-25

申请人： Syngenta Limited

发明人： BERRY, Ian Gordon ,  COX, Brian Jeffrey ,  DE BOOS, Gareth Andrew ,  FLEMING, Ian George ,  JONES, Raymond Vincent, Heavon ,  WHITTON, Alan John

IPC分类号： C07D239/34

CPC分类号： C07D239/34

摘要： A process for preparing a compound of formula (I) comprising treating a compound of formula (II) with either (a) an acid catalyst optionally in the presence of a means for removing methanol, or (b) an acid chloride; provided that when the acid catalyst is p-toluene sulphonic acid or potassium bisulphite then the process is conducted in the presence of an acid anhydride.