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公开(公告)号：EP1187833A1
公开(公告)日：2002-03-20
申请号：EP00942115.7
申请日：2000-06-21
IPC分类号： C07D417/06 , C07D401/06 , C07C257/22 , C07C277/08 , C07C261/00 , C07D213/61 , C07D277/36 , C07D307/14
CPC分类号： C07D213/40 , C07C257/22 , C07C261/00 , C07C277/08 , C07D213/38 , C07D277/28 , C07D307/14 , C07D401/06 , C07D417/06 , C07C279/36
摘要： Method of producing compounds of formula (I), wherein R1 is hydrogen or C1-C4-alkyl; R2 is hydrogen, C1-C8-alkyl, C3-C6-cycloalkyl, or a radical -N(R3)R4; or R2 and R6 together are -CH2-CH2-S-; R3 and R4 are hydrogen, C1-C4-alkyl, C3-C6-cycloalkyl or a radical -CH2B; R6 is hydrogen, C1-C8-alkyl, aryl or benzyl; or R3 and R6 together are -CH2-CH2-, -CH2-CH2-CH2-, -CH2-O-CH2-, -CH2-S-CH2- or -CH2-N(R5)-CH2-; X is CH-CN; CH-NO2 or N-NO2; A is an optionally substituted, aromatic or non-aromatic, monocyclic or bicyclic heterocyclic radical; and B is optionally substituted phenyl, 3-pyridyl or thiazolyl; characterised in that a compound of formula (II), wherein R2, R6 and X have the same significance as given above in formula (I), is reacted in the presence of a phase transfer catalyst and a base with a compound of formula (III), wherein A and R1 have the same significance as given above in formula (I) and Q is a leaving group.
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公开(公告)号：EP1187833B1
公开(公告)日：2007-06-06
申请号：EP00942115.7
申请日：2000-06-21
IPC分类号： C07D417/06 , C07D401/06 , C07C257/22 , C07C277/08 , C07C261/00 , C07D213/61 , C07D277/36 , C07D307/14
CPC分类号： C07D213/40 , C07C257/22 , C07C261/00 , C07C277/08 , C07D213/38 , C07D277/28 , C07D307/14 , C07D401/06 , C07D417/06 , C07C279/36
摘要： Method of producing compounds of formula (I), wherein R1 is hydrogen or C1-C4-alkyl; R2 is hydrogen, C1-C8-alkyl, C3-C6-cycloalkyl, or a radical -N(R3)R4; or R2 and R6 together are -CH2-CH2-S-; R3 and R4 are hydrogen, C1-C4-alkyl, C3-C6-cycloalkyl or a radical -CH2B; R6 is hydrogen, C1-C8-alkyl, aryl or benzyl; or R3 and R6 together are -CH2-CH2-, -CH2-CH2-CH2-, -CH2-O-CH2-, -CH2-S-CH2- or -CH2-N(R5)-CH2-; X is CH-CN; CH-NO2 or N-NO2; A is an optionally substituted, aromatic or non-aromatic, monocyclic or bicyclic heterocyclic radical; and B is optionally substituted phenyl, 3-pyridyl or thiazolyl; characterised in that a compound of formula (II), wherein R2, R6 and X have the same significance as given above in formula (I), is reacted in the presence of a phase transfer catalyst and a base with a compound of formula (III), wherein A and R1 have the same significance as given above in formula (I) and Q is a leaving group.
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