公开(公告)号：EP3355899A1

公开(公告)日：2018-08-08

申请号：EP16850516.2

申请日：2016-09-29

申请人： Ramot at Tel-Aviv University Ltd. ,  Yeda Research and Development Co. Ltd ,  Synvaccine Ltd.

发明人： TULLER, Tamir ,  GOZ, Eli ,  ATAR, Shimshi ,  ZUR, Hadas

IPC分类号： A61K35/76 ,  C12N7/04 ,  G06F19/10

CPC分类号： C12N7/00 ,  A61K35/76 ,  A61K39/12 ,  A61K2039/5254 ,  C12N2770/24121 ,  C12N2770/24162 ,  G06F19/10 ,  Y02A50/385 ,  Y02A50/387 ,  Y02A50/391 ,  Y02A50/465

摘要： Attenuated viruses and methods of designing them are disclosed. In one embodiment, there is disclosed an attenuated form of a virulent virus comprising an RNA encoding a viral protein or a nucleic acid sequence transcribable to said RNA, wherein the folding energy or structure of the RNA is changed at positions of evolutionarily conserved RNA structures with respect to that of said RNA encoding said viral protein in the virulent virus so as to bring about attenuation of the virus.

公开(公告)号：EP4133060A1

公开(公告)日：2023-02-15

申请号：EP21785320.9

申请日：2021-04-11

申请人： Synvaccine Ltd.

发明人： TULLER, Tamir ,  ZARAI, Yoram ,  ROOPIN, Modi ,  ZAFRIR, Zohar

IPC分类号： C12N7/00 ,  C12N7/04 ,  A61K39/12 ,  A61K35/76 ,  G16B15/10 ,  G16B25/10