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公开(公告)号：EP3355899A1
公开(公告)日：2018-08-08
申请号：EP16850516.2
申请日：2016-09-29
发明人： TULLER, Tamir , GOZ, Eli , ATAR, Shimshi , ZUR, Hadas
CPC分类号： C12N7/00 , A61K35/76 , A61K39/12 , A61K2039/5254 , C12N2770/24121 , C12N2770/24162 , G06F19/10 , Y02A50/385 , Y02A50/387 , Y02A50/391 , Y02A50/465
摘要： Attenuated viruses and methods of designing them are disclosed. In one embodiment, there is disclosed an attenuated form of a virulent virus comprising an RNA encoding a viral protein or a nucleic acid sequence transcribable to said RNA, wherein the folding energy or structure of the RNA is changed at positions of evolutionarily conserved RNA structures with respect to that of said RNA encoding said viral protein in the virulent virus so as to bring about attenuation of the virus.
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公开(公告)号：EP4139461A1
公开(公告)日：2023-03-01
申请号：EP21793489.2
申请日：2021-04-22
发明人： TULLER, Tamir , ARBEL, Matan , MENUHIN, Itamar , KATZIR, Itai , BERGMAN, Shaked , NAKI, Doron
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公开(公告)号：EP4423749A1
公开(公告)日：2024-09-04
申请号：EP22886317.1
申请日：2022-10-27
发明人： TULLER, Tamir , SHALLOM, David , WEISS, Shlomo , NAIGER, Danny
CPC分类号： G16B5/00
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公开(公告)号：EP4341444A1
公开(公告)日：2024-03-27
申请号：EP22804205.7
申请日：2022-05-19
发明人： TULLER, Tamir , GUTMAN, Tal
IPC分类号： C12Q1/6886 , G16B20/50 , G16B20/20 , G16B40/00 , G16B20/00
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公开(公告)号：EP4093866A1
公开(公告)日：2022-11-30
申请号：EP21744785.3
申请日：2021-01-24
申请人： B.G. Negev Technologies and Applications Ltd., at Ben-Gurion University , Ramot at Tel-Aviv University Ltd.
发明人： TULLER, Tamir , PEERI, Michael , CHEMLA, Yonatan , ALFONTA, Lital
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公开(公告)号：EP4093867A1
公开(公告)日：2022-11-30
申请号：EP21744974.3
申请日：2021-01-24
发明人： TULLER, Tamir , PEERI, Michael
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公开(公告)号：EP3947692A1
公开(公告)日：2022-02-09
申请号：EP20777652.7
申请日：2020-03-26
发明人： TULLER, Tamir , BAHIRI, Shir , APT, Boaz
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公开(公告)号：EP2545176B1
公开(公告)日：2016-05-11
申请号：EP11704680.5
申请日：2011-01-25
CPC分类号： C12N15/67 , C07K14/505 , C07K14/555 , C07K14/59 , C07K14/61 , C07K14/62 , C07K14/705 , C07K14/755 , C12N9/2402 , C12N9/2465 , C12P21/02
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公开(公告)号：EP2545176A1
公开(公告)日：2013-01-16
申请号：EP11704680.5
申请日：2011-01-25
CPC分类号： C12N15/67 , C07K14/505 , C07K14/555 , C07K14/59 , C07K14/61 , C07K14/62 , C07K14/705 , C07K14/755 , C12N9/2402 , C12N9/2465 , C12P21/02
摘要： Isolated polynucleotides are disclosed which increase the efficiency of gene expression in a heterologous cell. The polynucleotide sequences which encode polypeptides are adapted such that the average rate of translation of the first at least about 30 amino acids is slower by at least two fold than the average rate of translation of the remaining amino acids of the polypeptide.
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公开(公告)号：EP4133060A1
公开(公告)日：2023-02-15
申请号：EP21785320.9
申请日：2021-04-11
申请人： Synvaccine Ltd.
发明人： TULLER, Tamir , ZARAI, Yoram , ROOPIN, Modi , ZAFRIR, Zohar
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