公开(公告)号：EP1911755B1

公开(公告)日：2011-09-14

申请号：EP06780997.0

申请日：2006-07-12

申请人： TAIHO PHARMACEUTICAL CO., LTD.

发明人： URADE, Yoshihiro Gran Sitio Shimogamo ,  TANAKA, Yoshiki ,  YAMANE, Keiko c/o TAIHO PHARMACEUTICAL CO., LTD. ,  TOGAWA, Michinori, TAIHO PHARMACEUTICAL CO., LTD.

IPC分类号： C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/04 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14 ,  A61K31/4184 ,  A61K31/422 ,  A61K31/428 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/496 ,  A61K31/501 ,  A61K31/5377 ,  A61P25/28 ,  A61P29/00

CPC分类号： C07D405/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14

摘要： A benzoimidazole compound represented by the general formula (I) or a salt thereof: (I) wherein X1 represents an oxygen atom or a carbonyl group; and R1 represents a furan ring having 1 to 3 substituents or a pyrrole ring which may have 1 to 3 substituents, provided that a compound represented by the general formula (I) wherein the substituent is a phosphoric acid group or a phosphate ester group is excluded. The benzoimidazole compound or salt thereof has an excellent prostaglandin D synthetase inhibitory activity, and is useful as a prophylactic and/or therapeutic agent for a disease associated with prostaglandin D2 or a metabolite thereof, such as an allergic disease or an inflammatory disease or as an inhibitor for the exacerbation of Alzheimer disease or cerebral damage.

公开(公告)号：EP1911755A1

公开(公告)日：2008-04-16

申请号：EP06780997.0

申请日：2006-07-12

申请人： TAIHO PHARMACEUTICAL CO., LTD.

发明人： URADE, Yoshihiro Gran Sitio Shimogamo ,  TANAKA, Yoshiki ,  YAMANE, Keiko c/o TAIHO PHARMACEUTICAL CO., LTD. ,  TOGAWA, Michinori, TAIHO PHARMACEUTICAL CO., LTD.

IPC分类号： C07D401/14 ,  A61K31/4184 ,  A61K31/422 ,  A61K31/428 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/496 ,  A61K31/501 ,  A61K31/5377 ,  A61P25/28 ,  A61P29/00 ,  A61P37/08 ,  A61P43/00 ,  C07D403/04 ,  C07D403/14 ,  C07D405/04 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14

CPC分类号： C07D405/04 ,  C07D401/14 ,  C07D403/04 ,  C07D403/14 ,  C07D405/14 ,  C07D413/14 ,  C07D417/14

摘要： The present invention provides a benzimidazole compound represented by Formula (I)

wherein X 1 is oxygen or carbonyl, and R 1 is a furan ring having 1 to 3 substituents or a pyrrole ring that may have 1 to 3 substituents; excluding compounds represented by Formula (I) wherein at least one of the substituents is a phosphoric acid group or a phosphoric ester group; or a salt thereof. The benzimidazole compound or salt thereof has excellent prostaglandin synthase inhibitory activity, and is useful as an agent for preventing and/or treating diseases in which prostaglandin D2 or metabolites thereof participates, such as allergic and inflammatory diseases, and as inhibitor for the exacerbation of Alzheimer's disease or cerebral damage.

摘要翻译： 本发明提供由式（I）表示的苯并咪唑化合物，其中X 1是氧或羰基，R 1是具有1至3个取代基的呋喃环或可具有1至3个取代基的吡咯环; 不包括由式（I）表示的化合物，其中至少一个取代基是磷酸基或磷酸酯基; 或其盐。 苯并咪唑化合物或其盐具有优异的前列腺素合成酶抑制活性，并且可用作预防和/或治疗前列腺素D2或其代谢物参与的疾病如过敏性和炎性疾病，以及作为阿尔茨海默氏症恶化的抑制剂 疾病或脑损伤。