公开(公告)号：EP0735047A4

公开(公告)日：1996-11-27

申请号：EP95902957

申请日：1994-12-14

申请人： TAISHO PHARMA CO LTD

发明人： YOKOO CHIHIRO ,  WADA HISAYA ,  MITOME HIDEMICHI ,  SANO TATSUHIKO ,  HATAYAMA KATSUO ,  YAMADA YASUJI

IPC分类号： C07J7/00 ,  C07J9/00 ,  C07J17/00 ,  C07J21/00 ,  A61K31/58

CPC分类号： C07J21/006 ,  C07J7/002 ,  C07J9/00 ,  C07J17/00

摘要： To provide a novel antitumor steroid compound which can be synthesized efficiently and stereoselectively by the technique of organic synthetic chemistry. A steroid derivative represented by general formula (I) or a salt thereof, wherein R represents C1-C13 alkyl; A represents hydroxyl or a group which can readily be hydrolyzed into a hydroxyl group; and X and Y represent in combination oxo or C2-C3 alkylenedioxy, or separately X represents hydroxyl, C1-C5 alkoxy or a group which can readily be hydrolyzed into a hydroxyl group, and Y represents hydrogen or C1-C5 alkoxy, provided Y represents hydrogen when X represents hydroxyl or a group which can readily be hydrolyzed into a hydroxyl group, while Y represents C1-C5 alkoxy when X represents C1-C5 alkoxy.