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    PROSTAGLANDIN DERIVATIVES
    1.
    发明公开
    PROSTAGLANDIN DERIVATIVES 审中-公开
    PROSTAGLANDINDERIVATE

    公开(公告)号：EP1598335A1

    公开(公告)日：2005-11-23

    申请号：EP04712705.5

    申请日：2004-02-19

    申请人： TAISHO PHARMACEUTICAL CO., LTD ,  Sato, Fumie

    发明人： SATO, Fumie ,  TANAMI, Tohru, c/o Taisho Pharmaceutical Co., Ltd. ,  ONO, Naoya, c/o Taisho Pharmaceutical Co., Ltd. ,  YAGI, Makoto, c/o Taisho Pharmaceutical Co., Ltd. ,  SEKI, Takayuki, c/o Taisho Pharmaceutical Co. Ltd. ,  SATO, Mariko, c/o Taisho Pharmaceutical Co., Ltd.

    IPC分类号： C07C405/00 ,  A61K31/5575 ,  A61P11/02 ,  A61P11/06 ,  A61P27/14 ,  A61P37/08 ,  A61P43/00

    CPC分类号： C07C405/0016

    摘要： A prostaglandin derivative represented by the formula
    (wherein X is a halogen atom; Y is ethylene group, vinylene group or ethylylene group; Z is a group represented by -(CH 2 ) m -, -O(CH 2 ) n - or -S(O)p-(CH 2 ) n - (m is an integer of 0 to 3; n is an integer of 0 to 2; and p is an integer of 0 to 2); R 1 is a hydrogen atom, a C 1-5 alkyl group or a substituted C 1-5 alkyl group; R 2 is a C 3-10 cycloalkyl group, a C 3-10 cycloalkyl group substituted by C 1-4 alkyl group or C 4-15 cycloalkylalkyl group; and R 3 is a hydrogen atom, a halogen atom or a C 1-5 alkyl group or a substituted C 1-5 alkyl group), a pharmaceutically acceptable salt thereof or a hydrate thereof which has an excellent antagonism to prostaglandin DP receptor and, therefore, is useful against diseases such as allergic rhinitis, nasal obstruction, asthma, allergic conjunctivitis, systemic mastocytosis and disorder of systemic mast cell activation.

    摘要翻译： 由式表示的前列腺素衍生物（其中X为卤素原子; Y为亚乙基，亚乙烯基或亚乙烯基; Z为 - （CH 2）m - ， - O（CH 2）n - -S（O）p-（CH 2）n - （m为0〜3的整数; n为0〜2的整数，p为0〜2的整数）; R 1为氢原子 ，C 1-5烷基或取代的C 1-5烷基; R 2是C 3-10环烷基，被C 1-4烷基或C 4-15环烷基烷基取代的C 3-10环烷基; R 对前列腺素DP受体具有优异的拮抗作用，其中，3是氢原子，卤素原子或C 1-5烷基或取代的C 1-5烷基），其药学上可接受的盐或其水合物， 可用于治疗过敏性鼻炎，鼻塞，哮喘，过敏性结膜炎，系统性肥大细胞增多症和系统性肥大细胞活化紊乱等疾病。

    PROSTAGLANDIN DERIVATIVES
    3.
    发明公开
    PROSTAGLANDIN DERIVATIVES 有权
    前列腺素衍生物

    公开(公告)号：EP1553083A1

    公开(公告)日：2005-07-13

    申请号：EP03741366.3

    申请日：2003-07-11

    申请人： TAISHO PHARMACEUTICAL CO., LTD ,  Tanami, Tohru, c/o Taisho Pharmaceutical Co.,Ltd.

    发明人： TANAMI, Tohru, c/o Taisho Pharmaceutical Co., Ltd. ,  YAGI, Makoto, c/o Taisho Pharmaceutical Co., Ltd. ,  ONO, Naoya, c/o Taisho Pharmaceutical Co., Ltd. ,  SATO, Fumie

    IPC分类号： C07C405/00 ,  A61K31/5575 ,  A61P25/20

    CPC分类号： C07C405/0033

    摘要： A prostaglandin derivative represented by Formula (I) :
    wherein X is a halogen atom in the α- or β-substitution, Y is an ethylene group, a vinylene group or an ethynylene group, R 1 is a C 3-10 cycloalkyl group, a C 3-10 cycloalkyl group substituted with a C 1-4 straight or branched chain alkyl group or a C 4-13 cycloalkylalkyl group, R 2 is a hydrogen atom or a CO 2 R 3 group (R 3 is a hydrogen atom, a C 1-4 straight or branched chain alkyl group or a C 2-4 straight or branched chain alkenyl group), n is an integer of 1 to 4 and p is 0, 1 or 2,
    a pharmaceutically acceptable salt thereof or a hydrate thereof.

    摘要翻译： 式（I）所示的前列腺素衍生物：其中X为α-或β-取代基中的卤素原子，Y为亚乙基，亚乙烯基或亚乙炔基，R1为C3-10环烷基，C3 被C 1-4直链或支链烷基或C 4-13环烷基烷基取代的环烷基，R 2是氢原子或CO 2 R 3基团（R 3是氢原子，C 1-4直链或支链烷基 或C2-4直链或支链烯基），n是1至4的整数，并且p是0,1或2，其药学上可接受的盐或其水合物。