公开(公告)号：EP0307167A3

公开(公告)日：1990-01-24

申请号：EP88308230.7

申请日：1988-09-06

申请人： TAISHO PHARMACEUTICAL CO. LTD

发明人： Nakatsuka, Shin-ichi ,  Hayashi, Masatoshi ,  Yokomori, Sadakazu ,  Nakashima Yoshimoto ,  Hatayama, Katsuo ,  Araki, Hiroaki

IPC分类号： C07D461/00 ,  A61K31/475

CPC分类号： C07D461/00

摘要： Vincaminic acid derivatives represented by the formula
wherein R¹ is a hydrogen atom, an alkyl group having 1 to 8 carbon atoms or an alkoxyalkyl group having 2 to 6 carbon atoms, R² is a hydrogen atom, an alkyl group having 1 to 10 carbon atoms, a halogenated alkyl group having 1 to 5 carbon atoms, a cycloalkyl group having 3 to 6 carbon atoms, an alkoxycarbonylallyl group having 3 to 8 carbon atoms, an alkenyl group having 2 to 4 carbon atoms, a phenyl group, a phenyl group substituted by alkoxy groups each having 1 or 2 carbon atoms or a thienyl group, A is a hydroxyl group, B is a hydrogen atom, or A and B together form a valence bond, and the acid addition salts thereof are disclosed. These compound are useful as therapeutic effect on cerebovascular injuries.

摘要翻译： 其中R 1为氢原子，碳原子数为1〜8的烷基或碳原子数为2〜6的烷氧基烷基的式CHEM所代表的季胺酸衍生物为氢原子， 碳原子数1〜10的烷基，碳原子数1〜5的卤代烷基，碳原子数3〜6的环烷基，碳原子数3〜8的烷氧基羰基烯基，碳原子数2〜4的烯基， 苯基，被烷氧基或碳原子数为2的烷氧基取代的苯基或噻吩基，A为羟基，B为氢原子或A和B一起形成价键，酸加成盐 公开。 这些化合物可用作脑血管损伤的治疗效果。

公开(公告)号：EP0361888B1

公开(公告)日：1994-05-04

申请号：EP89309829.3

申请日：1989-09-27

申请人： TAISHO PHARMACEUTICAL CO. LTD

发明人： Hayashi, Masatoshi ,  Yokomori, Sadakazu ,  Nakashima, Yoshimoto ,  Hatayama, Katsuo

IPC分类号： C07D461/00 ,  A61K31/435

CPC分类号： C07D461/00

公开(公告)号：EP0307167A2

公开(公告)日：1989-03-15

申请号：EP88308230.7

申请日：1988-09-06

申请人： TAISHO PHARMACEUTICAL CO. LTD

发明人： Nakatsuka, Shin-ichi ,  Hayashi, Masatoshi ,  Yokomori, Sadakazu ,  Nakashima Yoshimoto ,  Hatayama, Katsuo ,  Araki, Hiroaki

IPC分类号： C07D461/00 ,  A61K31/475

CPC分类号： C07D461/00

摘要： Vincaminic acid derivatives represented by the formula
wherein R¹ is a hydrogen atom, an alkyl group having 1 to 8 carbon atoms or an alkoxyalkyl group having 2 to 6 carbon atoms, R² is a hydrogen atom, an alkyl group having 1 to 10 carbon atoms, a halogenated alkyl group having 1 to 5 carbon atoms, a cycloalkyl group having 3 to 6 carbon atoms, an alkoxycarbonylallyl group having 3 to 8 carbon atoms, an alkenyl group having 2 to 4 carbon atoms, a phenyl group, a phenyl group substituted by alkoxy groups each having 1 or 2 carbon atoms or a thienyl group, A is a hydroxyl group, B is a hydrogen atom, or A and B together form a valence bond, and the acid addition salts thereof are disclosed. These compound are useful as therapeutic effect on cerebovascular injuries.

摘要翻译： 由下式表示的氨基酸衍生物其中R 1是氢原子，具有1至8个碳原子的烷基或具有2至6个碳原子的烷氧基烷基，R 2是氢原子，具有1至10个碳原子的烷基， 具有1至5个碳原子的卤代烷基，具有3至6个碳原子的环烷基，具有3至8个碳原子的烷氧基羰基烯丙基，具有2至4个碳原子的烯基，苯基，被 各自具有1或2个碳原子的烷氧基或噻吩基，A是羟基，B是氢原子，或A和B一起形成价键，并且公开了其酸加成盐。 这些化合物对脑血管损伤有治疗作用。

公开(公告)号：EP0361888A3

公开(公告)日：1991-01-02

申请号：EP89309829.3

申请日：1989-09-27

申请人： TAISHO PHARMACEUTICAL CO. LTD

发明人： Hayashi, Masatoshi ,  Yokomori, Sadakazu ,  Nakashima, Yoshimoto ,  Hatayama, Katsuo

IPC分类号： C07D461/00 ,  A61K31/435

CPC分类号： C07D461/00

摘要： Apovincaminic acid derivatives useful in the treatment of cerebrovascular injuries, peripheral vessel injuries, angina pectoris, hypertension and senile dementia, are those of the formula:
wherein R is a C₂-C₁₁ alkylene group) and pharmaceutically acceptable salts thereof.

公开(公告)号：EP0361888A2

公开(公告)日：1990-04-04

申请号：EP89309829.3

申请日：1989-09-27

申请人： TAISHO PHARMACEUTICAL CO. LTD

发明人： Hayashi, Masatoshi ,  Yokomori, Sadakazu ,  Nakashima, Yoshimoto ,  Hatayama, Katsuo

IPC分类号： C07D461/00 ,  A61K31/435

CPC分类号： C07D461/00

摘要： Apovincaminic acid derivatives useful in the treatment of cerebrovascular injuries, peripheral vessel injuries, angina pectoris, hypertension and senile dementia, are those of the formula:
wherein R is a C₂-C₁₁ alkylene group) and pharmaceutically acceptable salts thereof.

摘要翻译： 可用于治疗脑血管损伤，外周血管损伤，心绞痛，高血压和老年痴呆症的氨基亚氨酸衍生物及其药学上可接受的盐是下式的化合物：其中R是C 2 -C 11亚烷基。