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    3-Benzoyl-2-mercaptopropionic acid derivatives
    3.
    发明公开
    3-Benzoyl-2-mercaptopropionic acid derivatives 失效
    3-苯甲酰基-2-Mercaptopropionsäure - 衍生物。

    公开(公告)号：EP0088585A1

    公开(公告)日：1983-09-14

    申请号：EP83301109.1

    申请日：1983-03-02

    申请人： TAISHO PHARMACEUTICAL CO. LTD

    发明人： Sota, Kaoru ,  Tachi, Yasuhide ,  Tomisawa, Kazuyuki ,  Kameo, Kazuya ,  Matsunaga, Toru ,  Sawada, Jiro

    IPC分类号： C07C153/09 ,  C07C153/11 ,  C07C149/20

    CPC分类号： C07C59/84 ,  C07C323/00 ,  C07C327/00

    摘要： Novel compounds having the general formula
    wherein X is hydrogen or halogen, Y is hydrogen, halogen, methoxy or alkyl having 1 to 3 carbon atoms, Z is hydrogen, alkylcarbonyl having 2 to 6 carbon atoms or benzoyl, and R is hydrogen, alkali metal or alkyl having 1 to 5 carbon atoms, are disclosed. These compounds exhibit excellent hypolipidemic activity and little or no side effect.

    摘要翻译： 具有通式的新型化合物，其中X为氢或卤素，Y为氢，卤素，甲氧基或具有1至3个碳原子的烷基，Z为氢，具有2至6个碳原子的烷基羰基或苯甲酰基，R为氢 ，碱金属或具有1至5个碳原子的烷基。 这些化合物表现出优异的降血脂活性，很少或没有副作用。

    Cyanopyrrolidine derivatives
    10.
    发明公开
    Cyanopyrrolidine derivatives 审中-公开
    氰基吡咯烷衍生物

    公开(公告)号：EP1746086A1

    公开(公告)日：2007-01-24

    申请号：EP06023245.1

    申请日：2001-11-09

    申请人： TAISHO PHARMACEUTICAL CO., LTD

    发明人： Fukushima, Hiroshi ,  Hiratate, Akira ,  Takahashi, Masato ,  Kameo, Kazuya

    IPC分类号： C07D207/16 ,  C07D401/12 ,  A61K31/40 ,  A61P3/10

    CPC分类号： C07D401/06 ,  C07D207/16 ,  Y02P20/55

    摘要： A cyanopyrrolidine derivative represented by Formula (1):

    [wherein R 1 is a halogen atom, a hydroxyl group, an alkoxy group having 1 to 5 carbon atoms or an alkyl group having 1 to 5 carbon atoms, R 2 is a hydrogen atom, a halogen atom, a hydroxyl group, an alkoxy group having 1 to 5 carbon atoms or an alkyl group having 1 to 5 carbon atoms, or R 1 and R 2 together form an oxo, a hydroxyimino group, an alkoxyimino group having 1 to 5 carbon atoms or an alkylidene group having 1 to 5 carbon atoms,
    R 3 and R 4 are each a hydrogen atom, a halogen atom, a hydroxyl group, an alkoxy group having 1 to 5 carbon atoms or an alkyl group having 1 to 5 carbon atoms, or R 3 and R 4 together form an oxo, a hydroxyimino group, an alkoxyimino group having 1 to 5 carbon.atoms or an alkylidene group having 1 to 5 carbon atoms,
    X is an oxygen atom or a sulfur atom,
    Y is -CR 5 R 6 - (wherein R 5 and R 6 are the same or different, and are each a hydrogen atom, a halogen atom, an optionally substituted alkyl group having 1 to 10 carbon atoms or an optionally substituted alkenyl group having 2 to 10 carbon atoms),
    or -CR 7 R 8 -CR 9 R 10 - (wherein R 7 , R 8 , R 9 and R 10 are the same or different, and each a hydrogen atom, a halogen atom or an optionally substituted alkyl group having 1 to 10 carbon atoms, or R 7 and R 9 together with the carbon atom to which they are attached form an optionally substituted cycloalkyl group having 3 to 8 carbon atoms, an optionally substituted cycloalkenyl group having 4 to 8 carbon atoms, an optionally substituted bicycloalkyl group having 5 to 10 carbon atoms, or an optionally substituted bicycloalkenyl group having 5 to 10 carbon atoms) and
    Z is a hydrogen atom or an optionally substituted alkyl group having 1 to 10 carbon atoms, or Y and Z together with the nitrogen atom to which they are attached form an optionally substituted cyclic amino group having 2 to 10 carbon atoms], or a pharmaceutically acceptable salt thereof.

    摘要翻译： 由式（1）表示的氰基吡咯烷衍生物：[其中R1是卤素原子，羟基，具有1至5个碳原子的烷氧基或具有1至5个碳原子的烷基，R2是氢原子，卤素 原子，羟基，具有1至5个碳原子的烷氧基或具有1至5个碳原子的烷基，或者R 1和R 2一起形成氧代，羟基亚氨基，具有1至5个碳原子的烷氧基亚氨基或 具有1至5个碳原子的亚烷基，R 3和R 4各自为氢原子，卤素原子，羟基，具有1至5个碳原子的烷氧基或具有1至5个碳原子的烷基，或者R 3和R 4 一起形成氧代，羟基亚氨基，具有1至5个碳原子的烷氧基亚氨基或具有1至5个碳原子的亚烷基，X是氧原子或硫原子，Y是-CR 5 R 6 - （其中R 5和R 6 相同或不同，并且各自是氢原子，卤素原子，任选取代的烷基 1至10个碳原子或任选取代的具有2至10个碳原子的链烯基）或-CR 7 R 8 -CR 9 R 10 - （其中R 7，R 8，R 9和R 10相同或不同，并且各自为氢原子，卤素原子或 可以具有取代基的碳原子数1〜10的烷基，或者R 7和R 9与它们所连接的碳原子一起形成可以具有取代基的碳原子数3〜8的环烷基，可以具有取代基的碳原子数4〜8的环烯基 ，可以具有取代基的碳原子数5〜10的双环烷基或可以具有取代基的碳原子数5〜10的二环烯基），Z是氢原子或可以具有取代基的碳原子数1〜10的烷基，Y和Z一起 与它们所连接的氮原子一起形成任选取代的具有2-10个碳原子的环氨基]或其药学上可接受的盐。