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公开(公告)号:EP0717990B1
公开(公告)日:2000-05-24
申请号:EP94925636.6
申请日:1994-09-06
发明人: OKUYAMA, Shigeru Taisho Pharmaceutical Co., Ltd. , IMAGAWA, Yasuko Taisho Pharmaceutical Co., Ltd. , OGAWA, Shinichi Taisho Pharmaceutical Co., Ltd. , ARAKI, Hiroaki Taisho Pharmaceutical Co., Ltd. , OTOMO, Susumu Taisho Pharmaceutical Co., Ltd.
IPC分类号: A61K31/135 , A61K31/40 , A61K31/495 , A61K31/38
CPC分类号: A61K31/135 , A61K31/137
摘要: To provide a remedy for drug dependence which is lowly toxic and has an excellent effect. A composition for remedying drug dependence which contains a phenylalkylamine derivative represented by general formula (I) or a pharmaceutically acceptable salt thereof as the active ingredient, wherein X represents halogen, hydroxy or C1-C5 alkoxy; X represents hydrogen, halogen or C1-C5 alkoxy; R and R represent each independently C1-C7 alkyl; R represents phenyl which may be substituted by halogen, hydroxy or C1-C5 alkoxy; and m and n represent each an integer of 2 to 5.
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公开(公告)号:EP0717990A1
公开(公告)日:1996-06-26
申请号:EP94925636.6
申请日:1994-09-06
发明人: OKUYAMA, Shigeru Taisho Pharmaceutical Co., Ltd. , IMAGAWA, Yasuko Taisho Pharmaceutical Co., Ltd. , OGAWA, Shinichi Taisho Pharmaceutical Co., Ltd. , ARAKI, Hiroaki Taisho Pharmaceutical Co., Ltd. , OTOMO, Susumu Taisho Pharmaceutical Co., Ltd.
IPC分类号: A61K31/135
CPC分类号: A61K31/135 , A61K31/137
摘要: Provision of a drug for curing drug dependence which is less toxic and highly effective.
A therapeutic composition for drug dependence which comprises as an active ingredient a phenylalkylamine derivative represented by the formula:
(wherein X¹ is a halogen atom, a hydroxyl group or an alkoxy group having 1 to 5 carbon atoms, X² is a hydrogen atom, a halogen atom or an alkoxy group having 1 to 5 carbon atoms, each of R¹ and R² is an alkyl group having 1 to 7 carbon atoms, R³ is a phenyl group or a substituted phenyl group having as the substituent a halogen atom, a hydroxyl group or an alkoxy group having 1 to 5 carbon atoms, and each of m and n is an integer of 2 to 5) or a pharmaceutically acceptable salt thereof.摘要翻译: 提供毒品毒性较低的药物依赖药物。 一种用于药物依赖的治疗组合物,其包含作为活性成分的由下式表示的苯基烷基胺衍生物:其中X 1为卤素原子,羟基或具有1至5个碳原子的烷氧基, 2>是氢原子,卤素原子或碳原子数为1〜5的烷氧基,R 1和R 2各自为碳原子数1〜7的烷基,R 3为苯基 基团或具有1〜5个碳原子的羟基或烷氧基作为取代基的取代苯基,m和n分别为2〜5的整数)或其药学上可接受的盐。
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公开(公告)号:EP0672413A1
公开(公告)日:1995-09-20
申请号:EP92924891.2
申请日:1992-12-08
发明人: OKUYAMA, Shigeru Taisho Pharmaceutical Co., Ltd. , OTOMO, Susumu Taisho Pharmaceutical Co., Ltd. , KAWASHIMA, Yutaka Taisho Pharmaceutical Co., Ltd. , HATAYAMA, Katsuo Taisho Pharmaceutical Co., Ltd.
IPC分类号: A61K31/435 , A61K31/475
CPC分类号: A61K31/475
摘要: To provide novel consciousness disturbance ameliorant and anesthesia antagonist. A consciousness disturbance ameliorant and an anesthesia antagonist both containing (+)-2-nitroxyethyl apovincaminate as the active ingredient.
摘要翻译: 提供新型意识障碍改善剂和麻醉拮抗剂。 意识障碍改善剂和麻醉拮抗剂均含有(+) - 2-硝酰乙基apovincaminate作为活性成分。
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