公开(公告)号：EP0350251B1

公开(公告)日：1994-03-16

申请号：EP89306761.1

申请日：1989-07-04

申请人： TAISHO PHARMACEUTICAL CO. LTD ,  THE INSTITUTE OF MATERIA MEDICA OF CHINESE ACADEMY OF MEDICAL SCIENCES

发明人： Liu, Geng-tao c/o Inst. Materia Medica of Chinese ,  Huang, Liang c/o Inst. Materia Medica of Chinese ,  Rao, Er-chang c/o Inst. Materia Medica of Chinese ,  Zhou, Jin c/o Inst. Materia Medica of Chinese ,  Li, Yan c/o Inst. Materia Medica of Chinese ,  Hatayama, Katsuo ,  Yoshikawa, Kensei ,  Sano, Tatsuhiko ,  Higuchi, Shohei ,  Arai, Iwao

IPC分类号： C07D317/68

CPC分类号： C07D317/58

公开(公告)号：EP0350251A3

公开(公告)日：1990-03-14

申请号：EP89306761.1

申请日：1989-07-04

申请人： TAISHO PHARMACEUTICAL CO. LTD ,  THE INSTITUTE OF MATERIA MEDICA OF CHINESE ACADEMY OF MEDICAL SCIENCES

发明人： Liu, Geng-tao c/o Inst. Materia Medica of Chinese ,  Huang, Liang c/o Inst. Materia Medica of Chinese ,  Rao, Er-chang c/o Inst. Materia Medica of Chinese ,  Zhou, Jin c/o Inst. Materia Medica of Chinese ,  Li, Yan c/o Inst. Materia Medica of Chinese ,  Hatayama, Katsuo ,  Yoshikawa, Kensei ,  Sano, Tatsuhiko ,  Higuchi, Shohei ,  Arai, Iwao

IPC分类号： C07D317/68

CPC分类号： C07D317/58

摘要： N-substituted amide derivatives represented by the formula
wherein A is -CH(OH)- or -C(=O)-, R¹ is a hydrogen atom or an alkyl group having 1 to 3 carbon atoms, and R² is an alkyl group having 1 to 6 carbon atoms are useful for prevention and therapy for liver diseases.

公开(公告)号：EP0350251A2

公开(公告)日：1990-01-10

申请号：EP89306761.1

申请日：1989-07-04

申请人： TAISHO PHARMACEUTICAL CO. LTD ,  THE INSTITUTE OF MATERIA MEDICA OF CHINESE ACADEMY OF MEDICAL SCIENCES

发明人： Liu, Geng-tao c/o Inst. Materia Medica of Chinese ,  Huang, Liang c/o Inst. Materia Medica of Chinese ,  Rao, Er-chang c/o Inst. Materia Medica of Chinese ,  Zhou, Jin c/o Inst. Materia Medica of Chinese ,  Li, Yan c/o Inst. Materia Medica of Chinese ,  Hatayama, Katsuo ,  Yoshikawa, Kensei ,  Sano, Tatsuhiko ,  Higuchi, Shohei ,  Arai, Iwao

IPC分类号： C07D317/68

CPC分类号： C07D317/58

摘要： N-substituted amide derivatives represented by the formula
wherein A is -CH(OH)- or -C(=O)-, R¹ is a hydrogen atom or an alkyl group having 1 to 3 carbon atoms, and R² is an alkyl group having 1 to 6 carbon atoms are useful for prevention and therapy for liver diseases.

摘要翻译： 其中A为-CH（OH） - 或-C（= O） - ，R 1为氢原子或具有1至3个碳原子的烷基，由式CHEM表示的N-取代酰胺衍生物，以及 R 2是具有1至6个碳原子的烷基，可用于预防和治疗肝脏疾病。

公开(公告)号：EP0373771A3

公开(公告)日：1990-11-14

申请号：EP89311874.5

申请日：1989-11-16

申请人： TAISHO PHARMACEUTICAL CO. LTD ,  MITSUI TOATSU CHEMICALS, Inc.

发明人： Hanada, Kazunori ,  Otomo, Susumu ,  Takeshita, Kimiyo ,  Higuchi, Shohei ,  Ike, Yoshimasa

IPC分类号： A61K37/64

CPC分类号： A61K9/127 ,  A61K38/005

摘要： The invention provides pharmaceutical compositions for the treatment of bone diseases and for the treatment of allergic diseases, which compositions contain a cystatin as active ingredient. The invention also provides for the use of cystatin in the manufacture of pharmaceutical compositions for the treatment of bone diseases and of allergic diseases. The invention further provides methods for the treatment of bone diseases or allergic diseases using cystatins.

公开(公告)号：EP0373771A2

公开(公告)日：1990-06-20

申请号：EP89311874.5

申请日：1989-11-16

申请人： TAISHO PHARMACEUTICAL CO. LTD ,  MITSUI TOATSU CHEMICALS, Inc.

发明人： Hanada, Kazunori ,  Otomo, Susumu ,  Takeshita, Kimiyo ,  Higuchi, Shohei ,  Ike, Yoshimasa

IPC分类号： A61K37/64

CPC分类号： A61K9/127 ,  A61K38/005

摘要： The invention provides pharmaceutical compositions for the treatment of bone diseases and for the treatment of allergic diseases, which compositions contain a cystatin as active ingredient. The invention also provides for the use of cystatin in the manufacture of pharmaceutical compositions for the treatment of bone diseases and of allergic diseases. The invention further provides methods for the treatment of bone diseases or allergic diseases using cystatins.

摘要翻译： 本发明提供用于治疗骨疾病和用于治疗过敏性疾病的药物组合物，该组合物含有半胱氨酸蛋白酶抑制剂作为活性成分。 本发明还提供了半胱氨酸蛋白酶抑制剂在制备用于治疗骨疾病和过敏性疾病的药物组合物中的用途。 本发明还提供了使用胱氨酸蛋白酶治疗骨疾病或过敏性疾病的方法。