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公开(公告)号：EP0350251B1
公开(公告)日：1994-03-16
申请号：EP89306761.1
申请日：1989-07-04
申请人： TAISHO PHARMACEUTICAL CO. LTD , THE INSTITUTE OF MATERIA MEDICA OF CHINESE ACADEMY OF MEDICAL SCIENCES
发明人： Liu, Geng-tao c/o Inst. Materia Medica of Chinese , Huang, Liang c/o Inst. Materia Medica of Chinese , Rao, Er-chang c/o Inst. Materia Medica of Chinese , Zhou, Jin c/o Inst. Materia Medica of Chinese , Li, Yan c/o Inst. Materia Medica of Chinese , Hatayama, Katsuo , Yoshikawa, Kensei , Sano, Tatsuhiko , Higuchi, Shohei , Arai, Iwao
IPC分类号： C07D317/68
CPC分类号： C07D317/58
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公开(公告)号：EP0350251A3
公开(公告)日：1990-03-14
申请号：EP89306761.1
申请日：1989-07-04
申请人： TAISHO PHARMACEUTICAL CO. LTD , THE INSTITUTE OF MATERIA MEDICA OF CHINESE ACADEMY OF MEDICAL SCIENCES
发明人： Liu, Geng-tao c/o Inst. Materia Medica of Chinese , Huang, Liang c/o Inst. Materia Medica of Chinese , Rao, Er-chang c/o Inst. Materia Medica of Chinese , Zhou, Jin c/o Inst. Materia Medica of Chinese , Li, Yan c/o Inst. Materia Medica of Chinese , Hatayama, Katsuo , Yoshikawa, Kensei , Sano, Tatsuhiko , Higuchi, Shohei , Arai, Iwao
IPC分类号： C07D317/68
CPC分类号： C07D317/58
摘要： N-substituted amide derivatives represented by the formula
wherein A is -CH(OH)- or -C(=O)-, R¹ is a hydrogen atom or an alkyl group having 1 to 3 carbon atoms, and R² is an alkyl group having 1 to 6 carbon atoms are useful for prevention and therapy for liver diseases.-
公开(公告)号：EP0350251A2
公开(公告)日：1990-01-10
申请号：EP89306761.1
申请日：1989-07-04
申请人： TAISHO PHARMACEUTICAL CO. LTD , THE INSTITUTE OF MATERIA MEDICA OF CHINESE ACADEMY OF MEDICAL SCIENCES
发明人： Liu, Geng-tao c/o Inst. Materia Medica of Chinese , Huang, Liang c/o Inst. Materia Medica of Chinese , Rao, Er-chang c/o Inst. Materia Medica of Chinese , Zhou, Jin c/o Inst. Materia Medica of Chinese , Li, Yan c/o Inst. Materia Medica of Chinese , Hatayama, Katsuo , Yoshikawa, Kensei , Sano, Tatsuhiko , Higuchi, Shohei , Arai, Iwao
IPC分类号： C07D317/68
CPC分类号： C07D317/58
摘要： N-substituted amide derivatives represented by the formula
wherein A is -CH(OH)- or -C(=O)-, R¹ is a hydrogen atom or an alkyl group having 1 to 3 carbon atoms, and R² is an alkyl group having 1 to 6 carbon atoms are useful for prevention and therapy for liver diseases.摘要翻译： 其中A为-CH（OH） - 或-C（= O） - ，R 1为氢原子或具有1至3个碳原子的烷基，由式CHEM表示的N-取代酰胺衍生物，以及 R 2是具有1至6个碳原子的烷基，可用于预防和治疗肝脏疾病。
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公开(公告)号：EP0074008A2
公开(公告)日：1983-03-16
申请号：EP82107714.6
申请日：1982-08-23
发明人： Amano, Takehiro , Yoshikawa, Kensei , Sano, Tatsuhiko , Ohuchi, Yutaka , Ishiguro, Michihiro , Shiono, Manzo , Fujita, Yoshiji , Nishida, Takashi
IPC分类号： C07C69/612 , C07C67/343 , C07C69/736 , C07C69/65 , C07C69/618 , C07D207/20 , C07D235/02 , C07D491/052 , C07D333/08 , C07D263/58
CPC分类号： C07D263/57 , C07C57/30 , C07C57/42 , C07D207/20 , C07D333/24 , C07D471/04 , C07D491/04
摘要： A process for producing an a-arylalkanoic acid ester represented by the general formula
wherein Ar represents an aryl group which may optionally be substituted, and R' and R 2 , independently from each other, represents a lower alkyl group, which comprises reacting a Grignard reagent prepared from an aryl halide of the general formula
wherein Ar is as defined above and X 1 represents a halogen atom, and magnesium, with an a-haloalkanoic acid ester of the general formula
wherein R' and R 2 are as defined above, and X 2 represents a halogen atom, said reaction of the Grignard reagent with the a-haloalkanoic acid ester of general formula (III) being carried out in the presence of a nickel compound.-
公开(公告)号：EP0073447B1
公开(公告)日：1984-11-21
申请号：EP82107715.3
申请日：1982-08-23
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公开(公告)号：EP0067008A1
公开(公告)日：1982-12-15
申请号：EP82302681.0
申请日：1982-05-25
发明人： Amano, Takehiro , Ogawa, Toshihisa , Yoshikawa, Kensei , Shiobara, Yoshinori , Sano, Tatsuhiko , Ito, Shoichi , Ohuchi, Yutaka , Sawada, Jiro , Tanami, Tohru
IPC分类号： C07C69/618 , C07D307/12 , A61K31/215 , A61K31/34
CPC分类号： C07D307/12
摘要： A novel carboxylic acid ester having the following general formula
wherein R is alkoxyalkyl having 2 to 6 carbon atoms, cycloalkyl having 5 or 6 carbon atoms, tetrahydrofurfuryl, alkyl having 1 to 6 carbon atoms or said alkyl substituted with 1 or 2 hydroxyl groups, is a useful anti-inflammatory and analgesic agent.摘要翻译： 具有下列通式的新型羧酸酯，其中R为具有2至6个碳原子的烷氧基烷基，具有5或6个碳原子的环烷基，四氢糠基，具有1至6个碳原子的烷基或所述被1或2个羟基取代的烷基， 一种有用的抗炎和镇痛剂。
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公开(公告)号：EP0135249B1
公开(公告)日：1986-11-12
申请号：EP84303433.1
申请日：1984-05-21
发明人： Hatayama, Katsuo , Yoshikawa, Kensei , Sano, Tatsuhiko , Ohuchi, Yutaka , Ota, Tomomi , Sekiuchi, Kazuto , Sota, Kaoru
IPC分类号： C07C57/60 , C07C79/46 , C07C57/58 , C07C33/48 , C07C103/133 , C07D295/18 , C07C103/58 , C07D275/02 , C07C83/10 , C07D213/04 , C07C121/66
CPC分类号： C07D213/75 , C07C33/483 , C07C57/58 , C07C57/60 , C07C67/343 , C07C69/65 , C07C205/56 , C07C233/11 , C07D277/46 , C07D295/027 , C07D295/185
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公开(公告)号：EP0135249A1
公开(公告)日：1985-03-27
申请号：EP84303433.1
申请日：1984-05-21
发明人： Hatayama, Katsuo , Yoshikawa, Kensei , Sano, Tatsuhiko , Ohuchi, Yutaka , Ota, Tomomi , Sekiuchi, Kazuto , Sota, Kaoru
IPC分类号： C07C57/60 , C07C79/46 , C07C57/58 , C07C33/48 , C07C103/133 , C07D295/18 , C07C103/58 , C07D275/02 , C07C83/10 , C07D213/04 , C07C121/66
CPC分类号： C07D213/75 , C07C33/483 , C07C57/58 , C07C57/60 , C07C67/343 , C07C69/65 , C07C205/56 , C07C233/11 , C07D277/46 , C07D295/027 , C07D295/185
摘要： Novel styrene derivatives of the general formula
wherein
X is hydrogen or halogen, X' is halogen, R is hydrogen or methyl, and Y is hydroxymethyl, carboxyl, -COOR' or -COR 2 (wherein R' is alkyl, substituted alkyl, prenyl, geranyl, farnesyl, cyclohexyl or phthalidyl, and R 2 is amino, hydroxyamino, mono-(or di-)alkylamino, ethoxycarbonylmethylamino, carboxymethylamino, phenylamino, substituted phenylamino, thiazolylamino, cyclohexylamino, pyridylamino, morpholino or N-methyl- piperazino), and the pharmaceutically acceptable salts thereof when Y is carboxyl, exhibit high and long-lasting anti-inflammatory, analgesic and anti-pyretic activity.-
公开(公告)号：EP0073447A1
公开(公告)日：1983-03-09
申请号：EP82107715.3
申请日：1982-08-23
发明人： Amano, Takehiro , Yoshikawa, Kensei , Sano, Tatsuhiko , Ohuchi, Yutaka , Ishiguro, Michihiro , Shiono, Manzo , Fujita, Yoshiji , Nishida, Takashi
摘要： A process for producing 1-(p-prenylphenyl)ethanol, which comprises reacting p-chloroprenylbenzene with magnesium at a temperature between 100°C and 150°C to form a Grignard reagent, and then reacting it with acetaldehyde.
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公开(公告)号：EP0067008B1
公开(公告)日：1985-08-21
申请号：EP82302681.0
申请日：1982-05-25
发明人： Amano, Takehiro , Ogawa, Toshihisa , Yoshikawa, Kensei , Shiobara, Yoshinori , Sano, Tatsuhiko , Ito, Shoichi , Ohuchi, Yutaka , Sawada, Jiro , Tanami, Tohru
IPC分类号： C07C69/618 , C07D307/12 , A61K31/215 , A61K31/34
CPC分类号： C07D307/12
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