公开(公告)号：EP0989113B1

公开(公告)日：2004-11-10

申请号：EP98929817.9

申请日：1998-07-03

申请人： TAITO CO., LTD. ,  Mitsubishi Pharma Corporation

发明人： HIRASE, Susumu, Taito Co., Ltd ,  SASAKI, Shigeo, Taito Co., Ltd ,  YONETA, Masahiko, Taito Co., Ltd ,  HIROSE, Ryoji, Taito Co., Ltd ,  FUJITA, Tetsuro

IPC分类号： C07C229/34 ,  C07C227/16 ,  C07C215/28 ,  C07C213/08 ,  C07C49/80 ,  C07C49/82 ,  C07C317/24 ,  B01J23/44

CPC分类号： C07C309/73 ,  C07C45/63 ,  C07C45/673 ,  C07C213/08 ,  C07C227/16 ,  C07C229/36 ,  C07C233/47 ,  Y02P20/55 ,  C07C49/80 ,  C07C49/82 ,  C07C215/28

摘要： A process for producing 2-aminomalonic acid derivatives of general formula (1) (wherein A is linear or branched alkylene having 1 to 10 carbon atoms; R1 is linear or branched alkyl having 2 to 20 carbon atoms; R?2 and R3¿ may be the same or different and each represents lower alkyl or aralkyl; and R4 is a protective group) characterized by reducing compounds of general formula (6) (wherein A, R?1, R2, R3 and R4¿ are each as defined above.

公开(公告)号：EP0989113A1

公开(公告)日：2000-03-29

申请号：EP98929817.9

申请日：1998-07-03

申请人： TAITO CO., LTD.

发明人： HIRASE, Susumu, Taito Co., Ltd ,  SASAKI, Shigeo, Taito Co., Ltd ,  YONETA, Masahiko, Taito Co., Ltd ,  HIROSE, Ryoji, Taito Co., Ltd ,  FUJITA, Tetsuro

IPC分类号： C07C229/34 ,  C07C227/16 ,  C07C215/28 ,  C07C213/08 ,  C07C49/80 ,  C07C49/82 ,  C07C317/24 ,  B01J23/44

CPC分类号： C07C309/73 ,  C07C45/63 ,  C07C45/673 ,  C07C213/08 ,  C07C227/16 ,  C07C229/36 ,  C07C233/47 ,  Y02P20/55 ,  C07C49/80 ,  C07C49/82 ,  C07C215/28

摘要： A process for preparing 2-amino malonic acid derivatives of formula (1):
wherein A is linear or branched chain alkylene having from 1 to 10 carbon atoms, R 1 is linear or branched chain alkyl having from 2 to 20 carbon atoms, R 2 and R 3 are the same or different, and are lower alkyl or aralkyl, and R 4 is a protecting group,
which process comprises the steps of reducing a compound of formula (6):
wherein A is linear or branched chain alkylene having from 1 to 10 carbon atoms, R 1 is linear or branched chain alkyl having from 2 to 20 carbon atoms, R 2 and R 3 are the same or different, and are lower alkyl or aralkyl, and R 4 is a protecting group.

摘要翻译： 制备式（1）的2-氨基丙二酸衍生物的方法：其中A为具有1至10个碳原子的直链或支链亚烷基，R 1为具有2至20个碳原子的直链或支链烷基 碳原子，R 2和R 3相同或不同，为低级烷基或芳烷基，R 4为保护基，该方法包括还原式（6）化合物的步骤： 其中A是具有1至10个碳原子的直链或支链亚烷基，R 1是具有2至20个碳原子的直链或支链烷基，R 2和R 3相同或不同， 不同，为低级烷基或芳烷基，R 4为保护基。