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公开(公告)号：EP0989113B1
公开(公告)日：2004-11-10
申请号：EP98929817.9
申请日：1998-07-03
发明人： HIRASE, Susumu, Taito Co., Ltd , SASAKI, Shigeo, Taito Co., Ltd , YONETA, Masahiko, Taito Co., Ltd , HIROSE, Ryoji, Taito Co., Ltd , FUJITA, Tetsuro
IPC分类号： C07C229/34 , C07C227/16 , C07C215/28 , C07C213/08 , C07C49/80 , C07C49/82 , C07C317/24 , B01J23/44
CPC分类号： C07C309/73 , C07C45/63 , C07C45/673 , C07C213/08 , C07C227/16 , C07C229/36 , C07C233/47 , Y02P20/55 , C07C49/80 , C07C49/82 , C07C215/28
摘要： A process for producing 2-aminomalonic acid derivatives of general formula (1) (wherein A is linear or branched alkylene having 1 to 10 carbon atoms; R1 is linear or branched alkyl having 2 to 20 carbon atoms; R?2 and R3¿ may be the same or different and each represents lower alkyl or aralkyl; and R4 is a protective group) characterized by reducing compounds of general formula (6) (wherein A, R?1, R2, R3 and R4¿ are each as defined above.
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2.发明授权PRODUCTION OF 2-AMINO-2- 2-(4-C 2-20?-ALKYL-PHENYL)ETHYL]PROPANE-1,3-DIOLS 有权制备2-氨基-2-（2-（4-烷基苯基）乙基）丙烷-1,3-二醇
公开(公告)号：EP1129066B1
公开(公告)日：2005-02-02
申请号：EP99971797.8
申请日：1999-11-09
IPC分类号： C07C215/28 , C07C213/08 , C07C22/04
CPC分类号： C07C233/47 , C07C17/16 , C07C17/208 , C07C17/35 , C07C22/04 , C07C29/00 , C07C45/46 , C07C45/63 , C07C213/00 , C07C215/28 , C07C49/80 , C07C49/76 , C07C215/08 , C07C33/20
摘要： Disclosed is a process for the production of 2-amino-2-[2-(4-C2-20-alkyl-phenyl)ethyl]propane-1,3-diols.
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3.发明公开PROCESSES FOR PRODUCING 2-AMINOMALONIC ACID DERIVATIVES AND 2-AMINO-1,3-PROPANEDIOL DERIVATIVES, AND INTERMEDIATES FOR PRODUCING THE DERIVATIVES 失效VERFAHREN ZUR HERSTELLUNG VON 2-AMINOMALONSÄURE-DERIVATEN
公开(公告)号：EP0989113A1
公开(公告)日：2000-03-29
申请号：EP98929817.9
申请日：1998-07-03
申请人： TAITO CO., LTD.
发明人： HIRASE, Susumu, Taito Co., Ltd , SASAKI, Shigeo, Taito Co., Ltd , YONETA, Masahiko, Taito Co., Ltd , HIROSE, Ryoji, Taito Co., Ltd , FUJITA, Tetsuro
IPC分类号： C07C229/34 , C07C227/16 , C07C215/28 , C07C213/08 , C07C49/80 , C07C49/82 , C07C317/24 , B01J23/44
CPC分类号： C07C309/73 , C07C45/63 , C07C45/673 , C07C213/08 , C07C227/16 , C07C229/36 , C07C233/47 , Y02P20/55 , C07C49/80 , C07C49/82 , C07C215/28
摘要： A process for preparing 2-amino malonic acid derivatives of formula (1):
wherein A is linear or branched chain alkylene having from 1 to 10 carbon atoms, R 1 is linear or branched chain alkyl having from 2 to 20 carbon atoms, R 2 and R 3 are the same or different, and are lower alkyl or aralkyl, and R 4 is a protecting group,
which process comprises the steps of reducing a compound of formula (6):
wherein A is linear or branched chain alkylene having from 1 to 10 carbon atoms, R 1 is linear or branched chain alkyl having from 2 to 20 carbon atoms, R 2 and R 3 are the same or different, and are lower alkyl or aralkyl, and R 4 is a protecting group.摘要翻译： 制备式（1）的2-氨基丙二酸衍生物的方法：其中A为具有1至10个碳原子的直链或支链亚烷基，R 1为具有2至20个碳原子的直链或支链烷基 碳原子，R 2和R 3相同或不同，为低级烷基或芳烷基，R 4为保护基，该方法包括还原式（6）化合物的步骤：
其中A是具有1至10个碳原子的直链或支链亚烷基，R 1是具有2至20个碳原子的直链或支链烷基，R 2和R 3相同或不同， 不同，为低级烷基或芳烷基，R 4为保护基。 -
公开(公告)号：EP0436020A1
公开(公告)日：1991-07-10
申请号：EP88908326.7
申请日：1988-09-14
发明人： FUJITA, Tetsuro , IKUMOTO, Takeshi , SASAKI, Shigeo , OKUMOTO, Takeki , CHIBA, Kenji, Koyamadai Elegant House No. 105
IPC分类号： C07C229/00 , C07D307/32 , A61K31/20 , A61K31/365
CPC分类号： C07D307/33 , C07C229/22 , C07C229/30 , C12P13/001 , C12P13/02 , C12P17/04
摘要： This invention relates to an immunosuppressant comprising an effective amount of at least one compound selected from among compounds represented by formula (I), (wherein R represents a hydrogen atom or an acyl group, Y represents carbonyl or hydroxymethylene group, and symbol ----- represents either a single bond or a double bond) and their lactones and a pharmaceutically acceptable carrier, a method of prophylaxis and treatment of immunorejection or autoimmune diseases comprising administering an effective amount of the above-described compound or its lactone, and a novel compound represented by formula (II) and its lactone.
摘要翻译： PCT No.PCT / JP88 / 00933 Sec。 371 1990年3月1日 102（e）1990年3月1日PCT PCT日期：1988年9月14日PCT公布。 出版物WO90 / 02727 1990年3月22日。本发明涉及一种免疫抑制剂，其包含至少一种选自式的化合物的化合物，其中R表示氢原子或酰基，Y表示羰基或羟基亚甲基，表示单键 或双键及其内酯，有效量和药学上可接受的载体; 一种抑制排斥反应或自身免疫性疾病的预防和治疗方法，其包括以有效量施用上述化合物或其内酯; 和一种新颖的式“IMAGE”或其内酯的化合物。
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5.发明公开PRODUCTION OF 2-AMINO-2- 2-(4-C 2-20?-ALKYL-PHENYL)ETHYL]PROPANE-1,3-DIOLS 有权制备2-氨基-2-（2-（4-烷基苯基）乙基）丙烷-1,3-二醇
公开(公告)号：EP1129066A1
公开(公告)日：2001-09-05
申请号：EP99971797.8
申请日：1999-11-09
申请人： Novartis AG , Novartis-Erfindungen Verwaltungsgesellschaft m.b.H. , TAITO CO., LTD. , WELFIDE CORPORATION
IPC分类号： C07C215/28 , C07C213/08 , C07C22/04
CPC分类号： C07C233/47 , C07C17/16 , C07C17/208 , C07C17/35 , C07C22/04 , C07C29/00 , C07C45/46 , C07C45/63 , C07C213/00 , C07C215/28 , C07C49/80 , C07C49/76 , C07C215/08 , C07C33/20
摘要： Disclosed is a process for the production of 2-amino-2-[2-(4-C2-20-alkyl-phenyl)ethyl]propane-1,3-diols.
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6.发明授权2-AMINOPROPANE-1,3-DIOL COMPOUNDS, MEDICINAL USE THEREOF, AND INTERMEDIATES IN SYNTHESIZING THE SAME 失效2-氨基丙烷-1,3-二醇化合物，其医药用途及其合成中间体产品提出
公开(公告)号：EP1002792B1
公开(公告)日：2004-07-14
申请号：EP98911211.5
申请日：1998-04-03
发明人： ADACHI, Kunitomo Yoshitomi Pharm. Industries, , AOKI, Yoshiyuki Yoshitomi Pharm. Industries, Ltd. , HANANO, Tokushi Yoshitomi Pharm. Industries, Ltd. , TESHIMA, Koji Yoshitomi Pharm. Industries, Ltd., , HOSHINO, Yukio Yoshitomi Pharm. Industries, Ltd. , FUJITA, Tetsuro
IPC分类号： C07C225/16 , C07C215/34 , C07C223/02 , A61K31/135
CPC分类号： C07C225/16 , C07C215/34 , C07C223/02 , C07F7/1852
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