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    Fused heterocyclic compounds, their production and use
    3.
    发明公开
    Fused heterocyclic compounds, their production and use 失效
    熔融杂环化合物，它们的生产和使用

    公开(公告)号：EP0518033A1

    公开(公告)日：1992-12-16

    申请号：EP92106621.3

    申请日：1992-04-16

    申请人： TAKEDA CHEMICAL INDUSTRIES, LTD.

    发明人： Naka, Takehiko ,  Inada, Yoshiyuki

    IPC分类号： C07D471/04 ,  C07D495/04 ,  C07D487/04 ,  C07D403/14 ,  C07D405/14 ,  C07D403/10 ,  C07D473/28 ,  C07D401/06 ,  A61K31/435 ,  A61K31/505 ,  A61K31/41

    CPC分类号： C07D401/06 ,  C07D401/14 ,  C07D403/10 ,  C07D403/14 ,  C07D405/14 ,  C07D471/04 ,  C07D473/30 ,  C07D487/04 ,  C07D495/04

    摘要： Fused heterocyclic compounds of the formula (I):

    wherein R¹ is an optionally substituted hydrocarbon residue which may be attached through a hetero atom; R² is a group capable of forming an anion or a group convertible thereinto; R³ is an optionally substituted aromatic hydrocarbon or heterocyclic residue which contains at least one hetero atom; X is a direct bond or a spacer having an atomic length of two or less between the R³ group and the ring W group; W is an optionally substituted aromatic hydrocarbon or heterocyclic residue which contains at least one hetero atom;
    a,c and d are independently selected from the group consisting of one or two optionally substituted carbon atoms and one or two optionally substituted hetero atoms; b and e are independently selected from the group consisting of one optionally substituted carbon atom and one optionally substituted nitrogen atom; the dotted line is a bond to form one double bond; n is an integer of 1 or 2 and when a, which is an optionally substituted carbon atom, is taken together with R¹, the following group:

    may form a ring group; provided that when

    is a benzimidazole, thieno[3,4-d]imidazole, or thieno[2,3-d]imidazole ring, at least one of the group:

    and R³ is an optionally substituted heterocyclic residue ; and the pharmaceutically acceptable salts thereof, have potent angiotensinII antagonistic activity and antihypertensive activity, thus being useful as therapeutic agents for treating circulatory system diseases such as hypertensive diseases, heart diseases (e.g. hypercardia, heart failure, cardiac infarction, etc.), strokes, cerebral apoplexy, nephritis, etc.

    摘要翻译： 式（I）的稠合杂环化合物：其中R 1是可通过杂原子连接的任选取代的烃残基; R 2是能够形成阴离子或可转化为其的基团的基团; R 3是含有至少一个杂原子的任选取代的芳烃或杂环残基; X是在R 3基团和环W基团之间原子长度等于或小于2的直接键或间隔基; W是含有至少一个杂原子的任选取代的芳族烃或杂环残基; a，c和d独立地选自一个或两个任选取代的碳原子和一个或两个任选取代的杂原子; b和e独立地选自一个任选取代的碳原子和一个任选取代的氮原子; 虚线是形成一个双键的键; n是1或2的整数，并且当任意取代的碳原子a与R 1一起时，下列基团可以形成环基团; 条件是当为苯并咪唑，噻吩并[3,4-d]咪唑或噻吩并[2,3-d]咪唑环时，至少一个基团：和R 3是任选取代的杂环残基; 及其药学上可接受的盐具有有效的血管紧张素II拮抗活性和抗高血压活性，因此可用作治疗循环系统疾病如高血压疾病，心脏疾病（例如高血压，心力衰竭，心肌梗塞等），中风， 脑卒中，肾炎等

    Heterocyclic compounds and their use as angiotensin II antagonists
    5.
    发明公开
    Heterocyclic compounds and their use as angiotensin II antagonists 失效
    Heterocyclische Verbindungen und ihre Verwendung als Angiotensin II Antagonisten

    公开(公告)号：EP0829479A1

    公开(公告)日：1998-03-18

    申请号：EP97120618.0

    申请日：1993-09-14

    申请人： TAKEDA CHEMICAL INDUSTRIES, LTD.

    发明人： Kubo, Keiji ,  Inada, Yoshiyuki ,  Naka, Takehiko

    IPC分类号： C07D413/12 ,  C07D417/12 ,  A61K31/44 ,  A61K31/47 ,  A61K31/505

    CPC分类号： C07D417/12 ,  C07D413/12

    摘要： The present invention relates to a compounds represented by the following formula or salts thereof.

    The above compounds have strong angiotensin II antagonistic action, antihypertensive action and action on central nervous system, which are useful for the treatment of circulatory diseases such as hypertension, heart diseases, cerebral apoplexy, nephritis, atherosclerosis or Alzheimer's disease and senile dementia, and for agents of improving cerebral function.

    摘要翻译： 本发明涉及由下式表示的化合物或其盐。 上述化合物具有强的血管紧张素II拮抗作用，抗高血压作用和对中枢神经系统的作用，其可用于治疗诸如高血压，心脏病，脑中风，肾炎，动脉粥样硬化或阿尔茨海默病和老年痴呆的循环系统疾病 ，以及改善脑功能的药物。

    Heterocyclic compounds having angiotensin II antagonistic activity and use thereof
    6.
    发明公开
    Heterocyclic compounds having angiotensin II antagonistic activity and use thereof 失效
    具有血管紧张素II拮抗活性的异环化合物及其用途。

    公开(公告)号：EP0603712A3

    公开(公告)日：1994-07-13

    申请号：EP93120135.4

    申请日：1993-12-14

    申请人： TAKEDA CHEMICAL INDUSTRIES, LTD.

    发明人： Kubo, Keiji ,  Inada, Yoshiyuki ,  Naka, Takehiko

    IPC分类号： C07D413/10 ,  C07D417/10 ,  A61K31/41

    CPC分类号： C07D413/10 ,  C07D417/10

    摘要： This invention relates to a compound represented by the formula

    wherein the ring A stands for a 5-10 membered aromatic heterocyclic group optionally having, besides R 1 and R 2 , further substituents; R 1 stands for an optionally substituted hydrocarbon residue which is optionally bonded through a hetero-atom; R 2 stands for a group capable of liberating proton in a living body or a group convertible thereinto; R 3 stands for an 5-7 membered optionally substituted heterocyclic residue having, as a group capable of constituting the ring, carbonyl group, thiocarbonyl group, an optionally oxidized sulfur atom or a group convertible into them; X shows that the ring Y and the ring W are bonded to each other directly or through a spacer having an atomic length of two or less; the ring W and the ring Y are each an optionally substituted aromatic hydrocarbon or aromatic heterocyclic residue; and n denotes an integer of 1 to 3, or a salt thereof and to an angiotensin II antagonistic agent containing the compound (I) or a salt thereof.

    1,2,4-Oxadiazolyl- or 1,2,4-thiadiazolyl-biphenyl derivatives as angiotensin II antagonists
    7.
    发明公开
    1,2,4-Oxadiazolyl- or 1,2,4-thiadiazolyl-biphenyl derivatives as angiotensin II antagonists 失效
    1,2,4-恶二唑基1,2,4-噻二唑基 - 衍生物als血管紧张素II拮抗剂。

    公开(公告)号：EP0588299A2

    公开(公告)日：1994-03-23

    申请号：EP93114754.0

    申请日：1993-09-14

    申请人： TAKEDA CHEMICAL INDUSTRIES, LTD.

    发明人： Kubo, Keiji ,  Inada, Yoshiyuki ,  Naka, Takehiko

    IPC分类号： C07D413/12 ,  C07D417/12 ,  A61K31/41 ,  A61K31/44 ,  A61K31/47 ,  A61K31/505

    CPC分类号： C07D417/12 ,  C07D413/12

    摘要： 57 The present invention relates to a compounds represented by the following formula or salts thereof.

    The above compounds have strong angiotensin II antagonistic action, antihypertensive action and action on central nervous system, which are useful for the treatment of circulatory diseases such as hypertension, heart diseases, cerebral apoplexy, nephritis, atherosclerosis or Alzheimer's disease and senile dementia, and for agents of improving cerebral function.

    摘要翻译： 本发明涉及由下式表示的化合物或其盐。 上述化合物具有强的血管紧张素II拮抗作用，抗高血压作用和对中枢神经系统的作用，其可用于治疗诸如高血压，心脏病，脑中风，肾炎，动脉粥样硬化或阿尔茨海默病和老年痴呆的循环系统疾病 ，以及改善脑功能的药物。