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15 条记录 (耗时 0.023 秒)

    Antiallergic, antiinflammatory and anti-PAF pyridazine compounds
    1.
    发明公开
    Antiallergic, antiinflammatory and anti-PAF pyridazine compounds 失效
    抗疟原虫，抗idaz idaz e e e e e。。。。。。。。。。。。。

    公开(公告)号：EP0548923A2

    公开(公告)日：1993-06-30

    申请号：EP92121818.6

    申请日：1992-12-22

    申请人： TAKEDA CHEMICAL INDUSTRIES, LTD.

    发明人： Miyake, Akio ,  Kawano, Yasuhiko ,  Ashida, Yasuko

    IPC分类号： C07D487/04 ,  C07D487/14 ,  C07D471/14 ,  C07D491/147 ,  A61K31/50

    CPC分类号： C07D487/04

    摘要： [Constitution] A compound represented by the formula [I],
    [Chemical Formula 1]


    [wherein X stands for a methine group or a nitrogen atom; R¹ stands for a hydrogen atom, an optionally substituted lower alkyl group or a halogen atom; R² and R³ respectively stand for a hydrogen atom or an optionally substituted lower alkyl group, or, taken together, may form a 5- to 7-membered ring combined with the adjacent -C=C-; R⁴ and R⁵ respectively stands for a hydrogen atom or an optionally substituted lower alkyl group or, taken together, form a 3- to 7-membered homo- or hetero-cyclic ring combined with the adjacent carbon atom; A stands for an optionally substituted amino group; m and n denote 1 to 4, respectively], salts thereof, a method of preparing same or pharmaceutical compositions containing same.
    [Effects] Excellent antiasthmatic agents

    摘要翻译： 由下式表示的新化合物：其中X代表次甲基（即基团-CH =）或氮原子; R 1表示氢原子，任选取代的低级烷基或卤素原子; R 2和R 3分别表示氢原子或任选取代的低级烷基，或者一起可以形成与相邻的-C = C-结合的5-至7-元环; R 4和R 5分别表示氢原子或任选取代的低级烷基，或者一起形成与相邻碳原子结合的3-至7-元同 - 或杂 - 环; A代表任选取代的氨基; m和n分别表示1至4个或其盐，其具有抗过敏，抗炎和抗PAF活性，并且可用作抗哮喘药。

    Imidazopyridazines as antiasthmatics
    4.
    发明公开
    Imidazopyridazines as antiasthmatics 失效
    咪唑并哒嗪als Antiasthmatika。

    公开(公告)号：EP0562440A1

    公开(公告)日：1993-09-29

    申请号：EP93104368.1

    申请日：1993-03-17

    申请人： TAKEDA CHEMICAL INDUSTRIES, LTD.

    发明人： Miyake, Akio ,  Kawano, Yasuhiko ,  Ashida, Yasuko

    IPC分类号： C07D487/04 ,  A61K31/50

    CPC分类号： C07D487/04

    摘要： Novel compound of the general formula:

    wherein R¹ stands for a hydrogen atom, an optionally substituted lower alkyl group or a halogen atom; R² and R³ respectively stand for a hydrogen atom or an optionally substituted lower alkyl group, provided that either R² or R³ is a hydrogen atom, the other being an optionally substituted lower alkyl group, or R² and R³ may, taken together with the adjacent -C=C- group, form a 5- to 7-membered ring; X stands for an oxygen atom or S(O) p (p stands for an integer from 0 to 2; Y stands for a group of the formula:

    (R⁴ and R⁵ respectively stand for a hydrogen atom or an optionally substituted lower alkyl group) or a divalent group derived from an optionally substituted 3- to 7-membered homocyclic or heterocyclic ring; R⁶ and R⁷ each stands for a hydrogen atom, an optionally substituted lower lakyl group, an optionally substituted cycloalkyl group or an optionally substituted aryl group, or R⁶ and R⁷ may, taken together with the adjacent nitrogen atom, form an optionally substituted nitrogen-containing heterocyclic group; m stands for an integer from 0 to 4; and n stands for an integer from 0 to 4, or a salt thereof, which has excellent anti-.PAF activities, and is of value as an antiasthmatic agent, and their production, intermediates and pharmaceutical compositions.

    摘要翻译： 新的通式化合物：其中R 1代表氢原子，任意取代的低级烷基或卤素原子; R 2和R 3分别代表氢原子或任选取代的低级烷基，条件是R 2或R 3为氢原子，另一个为任选取代的低级烷基， 或R 2和R 3可以与相邻的-C = C-基团一起形成5-至7-元环; X表示氧原子或S（O）p（p表示0至2的整数; Y表示下式的基团：（R 4和R 5分别代表氢 原子或任选取代的低级烷基）或衍生自任选取代的3-至7-元级环或杂环的二价基团; R 6和R 7各自代表氢原子，任选取代的低级烷基 基团，任选取代的环烷基或任选取代的芳基，或者R 6和R 7可以与相邻的氮原子一起形成任选取代的含氮杂环基; m代表 0〜4; n表示0〜4的整数或其盐，其具有优异的抗-PAF活性，并且作为抗哮喘药物的价值，以及它们的制备，中间体和药物组合物。

    Triazolopyridazines as antioasthmatics
    9.
    发明公开
    Triazolopyridazines as antioasthmatics 失效
    三唑并哒嗪als Antiasthmatika。

    公开(公告)号：EP0562439A1

    公开(公告)日：1993-09-29

    申请号：EP93104367.3

    申请日：1993-03-17

    申请人： TAKEDA CHEMICAL INDUSTRIES, LTD.

    发明人： Miyake, Akio ,  Kawano, Yasuhiko ,  Ashida, Asuko

    IPC分类号： C07D487/04 ,  A61K31/50

    CPC分类号： C07D487/04

    摘要： Novel compound represented by the formula:

    wherein R¹ stands for H, an optionally substituted lower alkyl group or a halogen; R² and R³ respectively stands for a hydrogen or an optionally substituted lower alkyl group, or R² and R³ may, taken together with the adjacent -C=C- group, form a 5- to 7-membered ring; X stands for O, SO or SO₂; Y stands for a group of the formula:

    (R⁴ and R⁵ respectively stand for H or an optionally substituted lower alkyl group) or a divalent group derived from an optionally substituted 3- to 7-membered homocyclic or heterocyclic ring; R⁶ and R⁷ each stands for H, an optionally substituted lower alkyl group, an optionally substituted cycloalkyl group or an optionally substituted aryl group, or R⁶ and R⁷ may, taken together with the adjacent N, form an optionally substituted N-containing heterocyclic group; m stands for 0 to 4; n stands for 0 to 4, or a salt thereof, which has excellent anti-PAF activities anti-LTC₄ activities and anti-ET-1 activities, and is of value as an antiasthmatic agent, and their production, intermediates and pharmasceutical compositions.

    摘要翻译： 由下式表示的新型化合物：其中R 1代表H，任选取代的低级烷基或卤素; R 2和R 3分别代表氢或任选取代的低级烷基，或R 2和R 3可以与相邻的-C = C-基团一起形成5- 至7元环; X代表O，SO或SO2; Y代表下式的基团：（R 4和R 5分别表示H或任选取代的低级烷基）或衍生自任选取代的3至7元级的环的二价基团 或杂环; R 6和R 7各自代表H，任选取代的低级烷基，任选取代的环烷基或任选取代的芳基，或R 6和R 7可以与相邻的 N，形成任选取代的含N杂环基; m代表0到4; n表示0〜4或其盐，其抗PAF活性优异，具有抗LTC4活性和抗ET-1活性，并且作为抗哮喘药物具有价值，其生产，中间体和药物组合物。