公开(公告)号：EP1783207A1

公开(公告)日：2007-05-09

申请号：EP05751180.0

申请日：2005-06-15

申请人： TANABE SEIYAKU CO., LTD.

发明人： NAKAO, Kazuwa ,  ITOH, Hiroshi ,  YAMASHITA, Jun ,  SONE, Masakatsu ,  YAMAHARA, Kenichi ,  KONDO, Yasushi ,  SUZUKI, Yutaka

IPC分类号： C12N5/06 ,  A61K35/12 ,  A61L27/00

CPC分类号： C12N5/0691 ,  A61K35/12 ,  C12N5/069 ,  C12N2506/02

摘要： To provide a method for differentiating primate embryonic stem cells into vascular endothelial cells, and a technique using the method. A method for differentiating primate embryonic stem cells into early developmental vascular endothelial cells comprising differentiating primate embryonic stem cells into vascular endothelial cell parker-positive cell population; the early developmental vascular endothelial cells; a method for producing the vascular endothelial cells; a method for amplifying the vascular endothelial cells; a vascular lesion-therapeutic agent containing the early developmental vascular endothelial cells as an active ingredient; a method for revascularization comprising supplying the early developmental vascular endothelial cells; a method for transplantation comprising transplanting the early developmental vascular endothelial cells; and a method for treatment comprising administering the early developmental vascular endothelial cells in a therapeutically effective dose.

摘要翻译： 是提供一种用于鉴别灵长类胚胎干细胞分化成血管内皮细胞的方法，以及使用该方法的技术。 一种用于鉴别灵长类胚胎干细胞分化成早期发育的血管内皮细胞，其包括鉴别灵长类胚胎干细胞分化成血管内皮细胞帕克阳性细胞群的方法; 早期发育血管内皮细胞; 用于制造血管内皮细胞的方法; 用于扩增血管内皮细胞的方法; 血管病变治疗剂含有的早期发育血管内皮细胞作为活性成分的; 血运重建包括提供的早期发育的血管内皮细胞的方法; 移植包括移植的早期发育的血管内皮细胞的方法; 和用于治疗的方法，包括以治疗有效的剂量给药的早期发育血管内皮细胞。