公开(公告)号：EP1657246B1

公开(公告)日：2007-10-10

申请号：EP05027718.5

申请日：2003-03-06

申请人： TATE & LYLE PUBLIC LIMITED COMPANY

发明人： Catani, Steven J. ,  Vernon, Nicholas M. ,  Merkel, Carolyn M. ,  Micinski, Edward ,  Wiley, James Edwin

IPC分类号： C07H13/08 ,  C07H5/02

CPC分类号： C07H1/06 ,  C07H5/02 ,  C07H13/08

公开(公告)号：EP1657246A1

公开(公告)日：2006-05-17

申请号：EP05027718.5

申请日：2003-03-06

申请人： TATE & LYLE PUBLIC LIMITED COMPANY

发明人： Catani, Steven J. ,  Vernon, Nicholas M. ,  Merkel, Carolyn M. ,  Micinski, Edward ,  Wiley, James Edwin

IPC分类号： C07H13/08 ,  C07H5/02

CPC分类号： C07H1/06 ,  C07H5/02 ,  C07H13/08

摘要： This invention relates to a method of obtaining sucralose from a feed mixture comprising 6-O-acyl-4,1',6'- trichloro-4,1',6'-trideoxygalactosucrose, other chlorinated sucrose byproducts, and optionally blocked or partially blocked chlorinated sucrose byproducts comprising the steps of:

(a) performing a non-crystallization extraction step on said feed mixture to obtain an increased purity 6-O-acyl-4,1',6'-trichloro-4,1',6'-trideoxygalactosucrose composition;
(b) performing a crystallization procedure on said increased purity 6-O-acyl-4,1',6'-trichloro-4,1',6'-trideoxygalactosucrose composition to obtain 6-O-acyl-4,1',6'-trichloro-4,1',6'-trideoxygalactosucrose and a mother liquor;
(c) performing at least three additional sequential crystallizations of the 6-O-acyl- 4, 1',6'-trichloro-4, 1',6'-trideoxygalactosucrose to obtain a substantially pure 6-O-acyl-4,1',6'-trichloro-4,1',6'-trideoxygalactosucrose and additional mother liquor; and
(d) converting said substantially pure 6-O-acyl-4,1',6'-trichloro-4,1',6'-trideoxygalactosucrose to substantially pure sucralose;

or the steps of:

(a) performing a non-crystallization extraction step on said feed mixture to obtain an increased purity sucralose precursor stream;
(b) converting said 6-O-acyl-4,1',6'-trichloro-4, 1',6'-trideoxygalactosucrose in said increased purity sucralose precursor stream to sucralose;
(c) crystallizing said sucralose to obtain a crystalline sucralose and a mother liquor; and
(d) performing at least three additional sequential crystallizations of said crystalline sucralose to obtain a substantially pure sucralose and additional mother liquor.

摘要翻译： 本发明涉及从进料混合物，其包含6-O-酰基 - 4,1”，6'-三氯-4,1' ，6'-脱氧半乳蔗糖，其它的氯化蔗糖的副产物，以及任选地封端的或部分获取三氯半乳蔗糖的方法 阻塞氯化蔗糖的副产物，包括以下步骤：（a）对所述进料混合物中的非结晶萃取步骤以获得在提高的纯度6-O-酰基 - 4,1”，6'-三氯-4,1' ，6 “-trideoxygalactosucrose组合物; （B）在执行上所述增加的纯度6-O-酰基-4,1-结晶过程“ 6'-三氯-4,1' ，6'-脱氧半乳蔗糖的组合物，以获得6-O-酰基-4,1”， 6'-三氯-4,1”，6'-脱氧半乳蔗糖和母液; （C）进行的6-O-酰基 - 4,1至少三个附加的顺序结晶”，6'-三氯-4，1' ，6'-脱氧半乳蔗糖，以获得基本上纯的6-O-酰基-4， 1”，6'-三氯-4,1' ，6'-脱氧半乳蔗糖和额外的母液; 和（d）将所述基本上纯的6-O-酰基-4,1”，6'-三氯-4,1' ，6'-脱氧半乳蔗糖到基本上纯的三氯半乳蔗糖; 或如下步骤：（a）对所述进料混合物中的非结晶萃取步骤以获得在提高纯度三氯半乳蔗糖前体流; （B）将所述6-O-酰基 - 4,1”，6'-三氯-4，1' ，6'-脱氧半乳蔗糖在所述增加的纯度三氯半乳蔗糖前体物流到三氯半乳蔗糖; （C）结晶分离所述三氯半乳蔗糖，得到结晶三氯半乳蔗糖和母液; 和（d）在执行所述结晶三氯半乳蔗糖的至少三个附加的顺序结晶，以获得基本上纯的三氯蔗糖和另外的母液。