公开(公告)号：EP3119421A4

公开(公告)日：2017-11-29

申请号：EP15765975

申请日：2015-03-18

申请人： TDW GROUP ,  WU BOR-WEN

发明人： WU BOR-WEN ,  ALMASSY ROBERT ,  HE WEI ,  SHOWALTER RICHARD E ,  HE JIAOJUAN ,  GUO YUNYUN ,  THOMSON JAMES A

IPC分类号： A61K38/50 ,  A61P35/00 ,  C12N9/78

CPC分类号： A61K38/50 ,  A61K45/06 ,  C12N9/78 ,  C12Y305/03006 ,  A61K2300/00

摘要： Provided are chimeric arginine deiminases, including pegylated chimeric arginine deiminases, and related compositions and methods of use thereof, including methods of treating cancer.

公开(公告)号：EP3166972A4

公开(公告)日：2018-01-31

申请号：EP15819121

申请日：2015-07-08

申请人： TDW GROUP

发明人： HE WEI ,  GUO YUNYUN ,  WU BOR-WEN

IPC分类号： C07K16/18 ,  A61K38/45 ,  A61K38/50 ,  A61K38/51 ,  A61K39/395 ,  A61K49/16 ,  A61K51/10 ,  C07K16/40 ,  C12N9/00 ,  C12N9/78 ,  G01N33/573 ,  G01N33/574

CPC分类号： C07K16/40 ,  A61K38/45 ,  A61K38/50 ,  A61K38/51 ,  C07K2317/20 ,  C07K2317/565 ,  C07K2317/76 ,  C12N9/78 ,  C12Y207/00 ,  C12Y207/03003 ,  C12Y305/03006 ,  C12Y401/01019 ,  G01N33/573 ,  G01N33/57496 ,  G01N2333/9015 ,  G01N2800/52

摘要： Antibodies, and antigen-binding fragments, which specifically bind to argininosuccinate synthase, and related compositions, kits, and methods of use, which are useful as companion diagnostics to identify suitable subjects for arginine deprivation or depletion therapies such as ADI-PEG 20 and other arginine deiminase (ADI) polypeptide-based therapies.