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1.发明公开ARGININE DEIMINASE WITH REDUCED CROSS-REACTIVITY TOWARD ADI - PEG 20 ANTIBODIES FOR CANCER TREATMENT 审中-公开精氨酸脱亚氨酶具有减少交叉反应反对ADI-PEG20抗体治疗癌症
公开(公告)号：EP2968482A4
公开(公告)日：2016-07-20
申请号：EP14769340
申请日：2014-03-13
申请人： POLARIS GROUP
发明人： ALMASSY ROBERT , SHOWALTER RICHARD E , THOMSON JAMES A , SISSON WES , SHIA WEI-JONG , CHEN LI-CHANG , LEE YANG
CPC分类号： A61K38/50 , A61K45/06 , C12N9/78 , C12Y305/03006
摘要： The present invention relates generally to isolated to arginine deiminase (ADI) proteins that have reduced cross-reactivity with anti-ADI-PEG 20 antibodies as compared to ADI-PEG 20, but which can have functional characteristics comparable to or better than ADI-PEG 20, compositions comprising the ADI proteins, and related methods of treating arginine-dependent diseases or related diseases such as cancer.
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2.发明公开YEAST EXPRESSION SYSTEMS, METHODS OF PRODUCING POLYPEPTIDES IN YEAST, AND COMPOSITIONS RELATING TO SAME 审中-公开酵母表达系统，过程用于在酵母多肽及任何相关组合物
公开(公告)号：EP1419263A4
公开(公告)日：2005-11-16
申请号：EP02759181
申请日：2002-07-25
发明人： CLARK MIKE A
IPC分类号： C07K14/525 , C12N1/19 , C12N9/78 , C12N15/81 , C12P21/00
CPC分类号： C07K14/525 , C12N9/78 , C12N15/815 , C12Y305/03006
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公开(公告)号：EP1278868A2
公开(公告)日：2003-01-29
申请号：EP01932862.4
申请日：2001-05-02
CPC分类号： C12N9/78 , A61K38/00 , A61K47/60 , C12N9/14 , C12N9/96 , C12Y305/03006 , Y02A50/401
摘要： The present invention discloses arginine deiminase that is genetically modified for more efficient manufacturing and processing. The present invention discloses recombinant DNA molecules and vectors and other therapeutic and pharmaceutical compositions. The present invention also discloses methods for preparing modified arginine deiminase as well as methods of treating cancer and other disease states using modified arginine deiminase.
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4.发明公开ARGININE DEIMINASE WITH REDUCED CROSS-REACTIVITY TOWARD ADI - PEG 20 ANTIBODIES FOR CANCER TREATMENT 审中-公开腺苷脱氨酶对ADI-PEG 20抗癌治疗的交叉反应性降低
公开(公告)号：EP3193913A1
公开(公告)日：2017-07-26
申请号：EP15842576.9
申请日：2015-09-16
申请人： Polaris Group , Showalter, Richard
发明人： SHOWALTER, Richard , ALMASSY, Robert , THOMSON, James A. , SISSON, Wes , SHIA, Wei-Jong , CHEN, Li-Chang , LEE, Yang
IPC分类号： A61K38/50
CPC分类号： A61K38/50 , A61K45/06 , A61K47/60 , C12N9/78 , C12Y305/03006
摘要： The present invention relates generally to isolated to arginine deiminase (ADI) proteins that have reduced cross-reactivity with anti-ADI-PEG 20 antibodies as compared to ADI-PEG 20, but which can have functional characteristics comparable to or better than ADI-PEG 20, compositions comprising the ADI proteins, and related methods of treating arginine-dependent diseases or related diseases such as cancer.
摘要翻译： 本发明一般涉及分离的精氨酸脱亚氨酶（ADI）蛋白，与ADI-PEG 20相比，其具有与ADI-PEG 20抗体的交叉反应性降低，但其可具有与ADI-PEG相当或更好的功能特征 20，包含ADI蛋白的组合物，以及治疗精氨酸依赖性疾病或相关疾病例如癌症的相关方法。
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公开(公告)号：EP1278868B9
公开(公告)日：2008-10-29
申请号：EP01932862.4
申请日：2001-05-02
申请人： Polaris Group
CPC分类号： C12N9/78 , A61K38/00 , A61K47/60 , C12N9/14 , C12N9/96 , C12Y305/03006 , Y02A50/401
摘要： The present invention discloses arginine deiminase that is genetically modified for more efficient manufacturing and processing. The present invention discloses recombinant DNA molecules and vectors and other therapeutic and pharmaceutical compositions. The present invention also discloses methods for preparing modified arginine deiminase as well as methods of treating cancer and other disease states using modified arginine deiminase.
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公开(公告)号：EP0981607B1
公开(公告)日：2006-08-09
申请号：EP98922197.3
申请日：1998-05-12
发明人： CLARK, Mike, A.
CPC分类号： C12N9/96 , A61K38/50 , A61K47/60 , C12N9/78 , C12Y305/03006 , Y02A50/401 , Y02A50/491
摘要： The present invention is directed to arginine deiminase modified with polyethylene glycol, to methods of treating cancer, and to methods of treating and/or inhibiting metastasis.
摘要翻译： 本发明涉及用聚乙二醇修饰的精氨酸脱亚胺酶，治疗癌症的方法以及治疗和/或抑制转移的方法。
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公开(公告)号：EP0981607A1
公开(公告)日：2000-03-01
申请号：EP98922197.3
申请日：1998-05-12
发明人： CLARK, Mike, A.
IPC分类号： C12N9/80
CPC分类号： C12N9/96 , A61K38/50 , A61K47/60 , C12N9/78 , C12Y305/03006 , Y02A50/401 , Y02A50/491
摘要： The present invention is directed to arginine deiminase modified with polyethylene glycol, to methods of treating cancer, and to methods of treating and/or inhibiting metastasis.
摘要翻译： 本发明涉及用聚乙二醇修饰的精氨酸脱亚胺酶，治疗癌症的方法以及治疗和/或抑制转移的方法。
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公开(公告)号：EP3166972A4
公开(公告)日：2018-01-31
申请号：EP15819121
申请日：2015-07-08
申请人： TDW GROUP
发明人： HE WEI , GUO YUNYUN , WU BOR-WEN
IPC分类号： C07K16/18 , A61K38/45 , A61K38/50 , A61K38/51 , A61K39/395 , A61K49/16 , A61K51/10 , C07K16/40 , C12N9/00 , C12N9/78 , G01N33/573 , G01N33/574
CPC分类号： C07K16/40 , A61K38/45 , A61K38/50 , A61K38/51 , C07K2317/20 , C07K2317/565 , C07K2317/76 , C12N9/78 , C12Y207/00 , C12Y207/03003 , C12Y305/03006 , C12Y401/01019 , G01N33/573 , G01N33/57496 , G01N2333/9015 , G01N2800/52
摘要： Antibodies, and antigen-binding fragments, which specifically bind to argininosuccinate synthase, and related compositions, kits, and methods of use, which are useful as companion diagnostics to identify suitable subjects for arginine deprivation or depletion therapies such as ADI-PEG 20 and other arginine deiminase (ADI) polypeptide-based therapies.
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公开(公告)号：EP3119421A4
公开(公告)日：2017-11-29
申请号：EP15765975
申请日：2015-03-18
申请人： TDW GROUP , WU BOR-WEN
发明人： WU BOR-WEN , ALMASSY ROBERT , HE WEI , SHOWALTER RICHARD E , HE JIAOJUAN , GUO YUNYUN , THOMSON JAMES A
CPC分类号： A61K38/50 , A61K45/06 , C12N9/78 , C12Y305/03006 , A61K2300/00
摘要： Provided are chimeric arginine deiminases, including pegylated chimeric arginine deiminases, and related compositions and methods of use thereof, including methods of treating cancer.
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公开(公告)号：EP2834262A4
公开(公告)日：2015-11-11
申请号：EP12873622
申请日：2012-05-30
申请人： POLARIS GROUP
发明人： BOMALASKI JOHN , WU BOR-WEN
IPC分类号： C07K14/00 , A61K31/337 , A61K31/436 , A61K33/24 , A61K38/00 , A61K45/06 , A61K47/48 , A61P35/00
CPC分类号： A61K47/67 , A61K31/337 , A61K31/436 , A61K33/24 , A61K38/50 , A61K45/06 , A61K47/60 , C12Y305/03006 , A61K2300/00
摘要： The present invention relates generally to methods of treating cancer with arginine deiminase, and in particular pegylated arginine deiminase.
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