公开(公告)号：EP1565185A4

公开(公告)日：2011-01-05

申请号：EP03773953

申请日：2003-11-07

申请人： TECHNION RES & DEV FOUNDATION ,  YEDA RES & DEV

发明人： YOUDIM MOUSSA B H ,  FRIDKIN MATITIYAHU ,  ZHENG HAILIN ,  WARSHAWSKY RIVKA ,  WARSHAWSKY ABRAHAM

IPC分类号： A61K31/47 ,  A61K45/06 ,  C07D213/69 ,  C07D215/26 ,  C07D295/15 ,  C07D295/205 ,  C07K7/22 ,  C07K7/23 ,  C07K14/575 ,  C07K14/70 ,  A61K31/4709 ,  A61K31/495 ,  C07D215/12

CPC分类号： C07D295/15 ,  A61K38/00 ,  A61K45/06 ,  A61K47/547 ,  C07D213/69 ,  C07D215/26 ,  C07D295/205 ,  C07K7/06 ,  C07K7/22 ,  C07K7/23 ,  C07K14/57563 ,  C07K14/70

摘要： Novel iron chelators exhibiting neuroprotective and good transport properties are useful in iron chelation therapy for treatment of a disease, disorder or condition associated with iron overload and oxidative stress, eg. a neurodegenerative or cerebrovascular disease or disorder, a neoplastic disease, hemochromatosis, thalassemia, a cardiovascular disease, diabetes, a inflammatory disorder, anthracycline cardiotoxicity, a viral infection, a protozoal infection, a yeast infection, retarding ageing, and prevention and/or treatment of skin ageing and skin protection against sunlight and/or UV light. The iron chelator function is provided by a 8-hydroxyquinoline, a hydroxypyridinone or a hydroxamate moiety, the neuroprotective function is imparted to the compound e.g. by a neuroprotective peptide, and a combined antiapoptotic and neuroprotective function by a propargyl group.