公开(公告)号：EP1477489A4

公开(公告)日：2006-03-08

申请号：EP03707008

申请日：2003-02-24

申请人： TEIJIN LTD

发明人： KATAOKA KENICHIRO ,  KOSUGI TOMOMI ,  ISHII TOSHIHIRO ,  TAKEUCHI TAKAHIRO ,  TSUTSUMI TAKAHARU ,  NAKANO AKIRA ,  UNOKI GEN ,  YAMAMOTO MASANORI ,  SAKAI YURI

IPC分类号： A61P3/10 ,  A61P17/14 ,  A61P25/18 ,  A61P25/24 ,  A61P25/28 ,  A61P29/00 ,  A61P35/00 ,  A61P37/02 ,  A61P43/00 ,  C07D487/04 ,  A61K31/519

CPC分类号： C07D487/04

摘要： (I) Pyrrolo[3,2-d] pyrimidine derivatives represented by the above general formula (I) or pharmaceutically acceptable salts thereof. Because of having a GSK-3 inhibitory effect, these compounds are expected as being useful as remedies or preventives for diseases in which GSK-3 participates such as diabetes, diabetic complications, Alzheimer’s disease, neurodegenerative disease, depression and mania, traumatic brain injury, hair loss, inflammatory diseases, cancer and immunodeficiency.

摘要翻译： （I）由上述通式（I）表示的吡咯并[3,2-d]嘧啶衍生物或其药学上可接受的盐。 由于具有GSK-3抑制作用，预计这些化合物可用作GSK-3参与的疾病例如糖尿病，糖尿病并发症，阿尔茨海默氏病，神经退行性疾病，抑郁症和躁狂症，创伤性脑损伤的治疗或预防， 脱发，炎性疾病，癌症和免疫缺陷。