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1.发明公开COMBINATION OF ANTINEOPLASTIC AGENT AND ANTISENSE OLIGONUCLEOTIDES FOR TREATMENT OF CANCER 失效抗肿瘤药基金和反义寡核苷酸在克雷布斯的治疗组合。
公开(公告)号：EP0668782A1
公开(公告)日：1995-08-30
申请号：EP93919965.0
申请日：1993-08-10
申请人： TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION , THOMAS JEFFERSON UNIVERSITY
CPC分类号： C12N15/113 , A61K45/06 , C12N15/1135 , C12N2310/312 , C12N2310/315
摘要： Therapeutic combinations of an antisense oligonucleotide and another, non-oligonucleotide chemotherapeutic agent are provided which allows for a reduced dosage of the non-oligonucleotide agent, and hence, reduced toxicity to the host. The antisense oligonucleotide component has a nucleotide sequence complementary to at least a portion of the mRNA transcript of a target oncogene or proto-oncongene, the amplification or expression of which is associated with the particular neoplastic disease under treatment. The combination is particularly useful in treating leukemias, more particularly as a bone marrow purging agent.
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2.发明授权COMBINATION OF ANTINEOPLASTIC AGENT AND ANTISENSE OLIGONUCLEOTIDES FOR TREATMENT OF CANCER 失效抗肿瘤药基金和反义寡核苷酸在癌症治疗中的组合
公开(公告)号：EP0668782B1
公开(公告)日：2001-04-11
申请号：EP93919965.9
申请日：1993-08-10
申请人： TEMPLE UNIVERSITY - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION , THOMAS JEFFERSON UNIVERSITY
CPC分类号： C12N15/113 , A61K45/06 , C12N15/1135 , C12N2310/312 , C12N2310/315
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