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公开(公告)号：EP0226516A2
公开(公告)日：1987-06-24
申请号：EP86402795.8
申请日：1986-12-12
IPC分类号： C07D295/12
CPC分类号： C07D295/13 , C07D211/14
摘要： Novel amide derivatives of formula
wherein R¹ and R², which may be the same or different, respectively represent a lower alkoxyl , a lower alkoxycarbonyl or a lower alkoxycarbonyloxy group, R³ represents a hydrogen atom or a lower alkoxyl group, m represents an integer of 1 or 2 and Y represents a group represented by the formula (II)
wherein p represents an integer of from 2 to 4 or a group represented by the formula (III)
wherein X represents a hydrogen arom, a halogen atom or a methoxy group and q represents an integer of from 2 to 4. these amide derivatives are useful as anti-allergic agents.-
2.发明授权Amide derivatives and 5-lypoxygenase inhibitors containing the same 失效酰胺衍生物和含有该衍生物的5-LYPOXYGENASE抑制剂
公开(公告)号：EP0217271B1
公开(公告)日：1993-03-17
申请号：EP86113087.0
申请日：1986-09-23
发明人： Takai, Makoto , Itoh, Noriie , Hattori, Shin , Hasegawa, Hirokazu Terumo K.K. Honmachiryo , Wakabayashi, Toshio
IPC分类号： C07C233/01 , A61K31/10
CPC分类号： A61K31/16 , C07C233/12
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3.发明公开
公开(公告)号：EP0217271A3
公开(公告)日：1989-01-11
申请号：EP86113087.0
申请日：1986-09-23
发明人： Takai, Makoto , Itoh, Noriie , Hattori, Shin , Hasegawa, Hirokazu Terumo K.K. Honmachiryo , Wakabayashi, Toshio
IPC分类号： C07C233/01 , A61K31/10
CPC分类号： A61K31/16 , C07C233/12
摘要： Novel amide derivatives are disclosed. As examples of said amide derivatives are mentioned N-cyclohexyl-N-methyl-(2-(3-(3-methoxy-4-hydroxyphenyl)-2-(propenoylamino)-3,5-dibromobenzyl)amine and N-cyclohexyl-N-methyl-(2-(5-(3-methoxy-4-hydroxyphenyl)-2,4-pentadienoylamino)-3,5-dibromobenzyl)amine. These amide derivatives have a 5-lipoxygenase inhibitory activity and are useful as an antiallergic agent.
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公开(公告)号：EP0226516B1
公开(公告)日：1992-07-29
申请号：EP86402795.8
申请日：1986-12-12
IPC分类号： C07D295/12
CPC分类号： C07D295/13 , C07D211/14
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公开(公告)号：EP0232205A3
公开(公告)日：1989-01-25
申请号：EP87400260.3
申请日：1987-02-04
发明人： Takai, Makoto , Hattori, Shin , Wakabayashi, Toshio , Suwabe, Yasusi Green Heights Chiyogaoka B-102 , Miyaoka, Syozo
IPC分类号： C07D295/08 , C07D295/06 , C07D295/02 , A61K31/495
CPC分类号： C07D295/03 , C07D295/073 , C07D295/096
摘要： Novel dienyl derivatives are disclosed. As examples of said diene derivative are mentioned 1-benzhydryl-4-(5-phenyl-2,4-pentadienyl)piperazine, 1-(4,4′-difluorobenzhydryl)-4-(5-phenyl-2,4-pentadienyl)piperazine, 1-benzhydryl-4-(5-(3,4,5-trimethoxyphenyl)-2,4-pentadienyl)piperazine, 1-(4,4′-difluorobenzhydryl)-4-(5-(2,4-dimethoxyphenyl)-2,4-pentadienyl)piperazine, 1-benzhydryl-4-(5-(2,3,4-trimethoxyphenyl)-2,4-pentadienyl)piperazine, 1-(4,4′-difluorobenzhydryl)-4-(5-(2,3,4-trimethoxyphenyl)-2,4-pentadienyl)piperazine and the like. These dienyl derivatives are useful as vasodilators.
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公开(公告)号：EP0232205A2
公开(公告)日：1987-08-12
申请号：EP87400260.3
申请日：1987-02-04
发明人： Takai, Makoto , Hattori, Shin , Wakabayashi, Toshio , Suwabe, Yasusi Green Heights Chiyogaoka B-102 , Miyaoka, Syozo
IPC分类号： C07D295/08 , C07D295/06 , C07D295/02 , A61K31/495
CPC分类号： C07D295/03 , C07D295/073 , C07D295/096
摘要： Novel dienyl derivatives are disclosed. As examples of said diene derivative are mentioned 1-benzhydryl-4-(5-phenyl-2,4-pentadienyl)piperazine, 1-(4,4′-difluorobenzhydryl)-4-(5-phenyl-2,4-pentadienyl)piperazine, 1-benzhydryl-4-(5-(3,4,5-trimethoxyphenyl)-2,4-pentadienyl)piperazine, 1-(4,4′-difluorobenzhydryl)-4-(5-(2,4-dimethoxyphenyl)-2,4-pentadienyl)piperazine, 1-benzhydryl-4-(5-(2,3,4-trimethoxyphenyl)-2,4-pentadienyl)piperazine, 1-(4,4′-difluorobenzhydryl)-4-(5-(2,3,4-trimethoxyphenyl)-2,4-pentadienyl)piperazine and the like. These dienyl derivatives are useful as vasodilators.
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7.发明公开
公开(公告)号：EP0217271A2
公开(公告)日：1987-04-08
申请号：EP86113087.0
申请日：1986-09-23
发明人： Takai, Makoto , Itoh, Noriie , Hattori, Shin , Hasegawa, Hirokazu Terumo K.K. Honmachiryo , Wakabayashi, Toshio
IPC分类号： C07C233/01 , A61K31/10
CPC分类号： A61K31/16 , C07C233/12
摘要： Novel amide derivatives are disclosed. As examples of said amide derivatives are mentioned N-cyclohexyl-N-methyl-(2-(3-(3-methoxy-4-hydroxyphenyl)-2-(propenoylamino)-3,5-dibromobenzyl)amine and N-cyclohexyl-N-methyl-(2-(5-(3-methoxy-4-hydroxyphenyl)-2,4-pentadienoylamino)-3,5-dibromobenzyl)amine. These amide derivatives have a 5-lipoxygenase inhibitory activity and are useful as an antiallergic agent.
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