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1.发明公开Formulations containing fenofibrate and a surfactant mixture 审中-公开Zusammensetzungen，welch Fenofibrat und eine Tensidmischung beinhaltet
公开(公告)号：EP1707197A1
公开(公告)日：2006-10-04
申请号：EP06250763.7
申请日：2006-02-13
发明人： Lerner, E. Itzhak , Rosenberger, Vered , Falshner-Barak, Moshe , Drabkin, Anna , Moldavski, Naomi
IPC分类号： A61K31/216
CPC分类号： A61K9/145 , A61K9/0007 , A61K9/146 , A61K9/1617 , A61K9/1641 , A61K9/2077 , A61K9/4858 , A61K9/4866 , A61K31/216 , A61K47/30 , A61K2300/00
摘要： The invention provides at least a composition for the treatment of elevated levels of triglycerides, comprising a therapeutically effective amount of a fibrate drug, preferably fenofibrate, intimately associated with a surfactant mixture, preferably a mixture comprising PGE 6000 and poloxamer 407. The invention also provides a method for the treatment of elevated levels of triglycerides in a subject, comprising administering to the subject the composition.
摘要翻译： 本发明提供至少一种用于治疗升高水平的甘油三酸酯的组合物，其包含治疗有效量的与表面活性剂混合物，优选包含PGE 6000和泊洛沙姆407的混合物紧密相关的贝特类药物，优选非诺贝特。本发明还提供 用于治疗受试者中甘油三酸酯水平升高的方法，包括向受试者施用组合物。
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公开(公告)号：EP1707196A1
公开(公告)日：2006-10-04
申请号：EP05258102.2
申请日：2005-12-29
IPC分类号： A61K31/216 , A61K47/10
CPC分类号： A61K9/2013 , A61K9/145 , A61K9/146 , A61K9/2031 , A61K9/4858 , A61K9/4866 , A61K31/192 , A61K31/216
摘要： The invention provides at least a composition for the treatment of elevated levels of triglycerides, comprising a therapeutically effective amount of fenofibrate or another fibrate drug intimately associated with menthol or a surfactant mixture, wherein the menthol can be menthol or menthol surfactant mixture, and wherein the surfactant mixture can be a mixture of a polyethylene glycol and a poloxamer such as PGE 1000 and poloxamer 407. The invention also provides a method for the treatment of elevated levels of triglycerides in a subject, comprising administering to the subject a composition comprising a therapeutically effective amount of fenofibrate or another fibrate drug and menthol or a surfactant mixture, wherein the fenofibrate or the other fibrate drug is in intimate association with the menthol or surfactant mixture, wherein the menthol can be menthol or menthol surfactant mixture, and wherein the surfactant mixture can be a mixture of a polyethylene glycol and a poloxamer such as PGE 1000 and poloxamer 407.
摘要翻译： 本发明提供至少一种用于治疗甘油三酯水平升高的组合物，其包含治疗有效量的非诺贝特或与薄荷醇或表面活性剂混合物紧密结合的另一种贝特类药物，其中薄荷醇可以是薄荷醇或薄荷醇表面活性剂混合物， 表面活性剂混合物可以是聚乙二醇和泊洛沙姆的混合物，例如PGE 1000和泊洛沙姆407.本发明还提供了用于治疗受试者中升高的甘油三酯水平的方法，其包括向受试者施用包含治疗有效 非诺贝特或另一种贝特类药物和薄荷醇或表面活性剂混合物的量，其中非诺贝特或其他贝特类药物与薄荷醇或表面活性剂混合物紧密结合，其中薄荷醇可以是薄荷醇或薄荷醇表面活性剂混合物，并且其中表面活性剂混合物可以 是聚乙二醇和泊洛沙姆素的混合物 如PGE 1000和泊洛沙姆407。
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