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公开(公告)号：EP1784398A1
公开(公告)日：2007-05-16
申请号：EP05796114.6
申请日：2005-09-02
发明人： HEDVATI, Lilach , PILARSKY, Gideon , RAIZI, Yuriy , MAROM, Esti
IPC分类号： C07D403/10
CPC分类号： C07D405/14
摘要： The present invention provides a process for purifying olmesartan medoxomil.
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公开(公告)号：EP1716138A1
公开(公告)日：2006-11-02
申请号：EP05793484.6
申请日：2005-09-02
IPC分类号： C07D403/10
CPC分类号： C07D405/14
摘要： The present invention provides a process for preparing olmesartan medoxomil at pH higher than 2.5.
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公开(公告)号：EP1268369A1
公开(公告)日：2003-01-02
申请号：EP01916635.4
申请日：2001-03-14
IPC分类号： C07B57/00
CPC分类号： C07C209/52 , C07B2200/09 , C07C2602/10 , C07C211/42
摘要： The present invention is directed to (+)-cis-sertraline hydrochloride and methods of preparation. The present invention also includes processes for making sertraline having a cis/trans ratio greater than 3:1, greater than or equal to 8:1, or between about 8:1 and about 12:1, from the Schiff base of sertralone, sertraline-1-imine.
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公开(公告)号：EP2046790A2
公开(公告)日：2009-04-15
申请号：EP08726227.5
申请日：2008-02-27
发明人： DOLITZKY, Ben-zion , SHAPIRO, Evgeny , INI, Santiago , SHMUELY, Yaron , LANCRY, Eli , PILARSKY, Gideon
IPC分类号： C07D471/04
CPC分类号： C07D213/73 , C07D471/04
摘要： The present invention provides processes of preparing 3-(2-chloroethyl)- 6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrrido[ 1,2-a]- pyrimidin-4-one (CMHTP) useful as intermediates for the preparation of paliperidone, wherein the processes use 3-(2-chloroethyl)-2-methyl-9-benzyloxy-4H-pyrido[ 1,2-a]pyrimidine-4- one (CMBP) and/or 3-(2-chloroethyl)-2-methyl-9-hydoxy-4H-pyrido[l,2- a]pyrimidine-4-one (CMHP) having phosphorus at least partially removed as the intermediate.
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公开(公告)号：EP1716139A1
公开(公告)日：2006-11-02
申请号：EP05796113.8
申请日：2005-09-02
发明人： HEDVATI, Lilach , PILARSKY, Gideon
IPC分类号： C07D403/10
CPC分类号： C07D405/14
摘要： The present invention provides the preparation of olmesartan medoxomil containing less than about 0.1% of one or more of the impurities OLM-Me, OLM -C1, and OLM-eliminate.
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公开(公告)号：EP1706401A1
公开(公告)日：2006-10-04
申请号：EP05797758.9
申请日：2005-09-02
发明人： HEDVATI, Lilach , PILARSKY, Gideon
IPC分类号： C07D403/10
CPC分类号： C07D403/10 , C07D405/14
摘要： The present invention provides a process for preparing olmesartan medoxomil.
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公开(公告)号：EP1628973A2
公开(公告)日：2006-03-01
申请号：EP04796522.3
申请日：2004-10-25
IPC分类号： C07D417/12
CPC分类号： C07D417/12
摘要： Provided are processes for preparing ziprasidone from 1, 2-benzothiazole-3-piperazinyl (BITP) and 5-(2-chloroethyl)-6-chloro-1, 3-dihydro-indole-2(2H) one (CEI) using various solvents, bases and promoters.
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