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公开(公告)号：EP0247856A3
公开(公告)日：1988-08-24
申请号：EP87304699
申请日：1987-05-27
发明人： Harris, William J.
摘要： Heterocyclic aromatic polymers are rapidly formed by contacting one or more appropriate multifunctional aromatic monomers, such as a diaminobenzenediol, a terephthaloyl halide and/or an aminohydroxybenzoic acid, with a sulfonic acid, as the solvent, and a dehydrating agent.
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公开(公告)号：EP1056860A1
公开(公告)日：2000-12-06
申请号：EP98910057.3
申请日：1998-02-25
发明人： Anderson, William Henry Kerr , Tempest, Philip R. , Carr, Frank J. , Harris, William J. , Armour, Kathryn
IPC分类号： C12N15/13 , C07K16/30 , C07K16/46 , C12N15/62 , C12N15/85 , A61K39/395 , A61K47/48 , A61K51/10 , G01N33/574 , G01N33/577
CPC分类号： C07K16/30 , A61K38/00 , A61K47/6851 , C07K2317/24 , C07K2319/00 , G01N33/57469
摘要： Novel humanized monoclonal antibodies, humanized antibody fragments, and derivatives thereof which specifically bind TAG-72 are provided as well as methods for their manufacture. These humanized antibodies are useful in the treatment of cancers which express TAG-72 as well as for diagnostic purposes, e.g., for in vivo imaging of tumors or cancer cells which express TAG-72.
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3.发明公开Preparation of aromatic heterocyclic polymers 失效Herstellung von aromatischen hybridlischen Polymeren。
公开(公告)号：EP0247856A2
公开(公告)日：1987-12-02
申请号：EP87304699.9
申请日：1987-05-27
发明人： Harris, William J.
摘要： Heterocyclic aromatic polymers are rapidly formed by contacting one or more appropriate multifunctional aromatic monomers, such as a diaminobenzenediol, a terephthaloyl halide and/or an aminohydroxybenzoic acid, with a sulfonic acid, as the solvent, and a dehydrating agent.
摘要翻译： 通过使一种或多种适当的多官能芳族单体如二氨基苯二酚，对苯二酰卤和/或氨基羟基苯甲酸与磺酸作为溶剂和脱水剂接触来快速形成杂环芳族聚合物。
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4.发明授权Copolymers containing polybenzoxazole polybenzothiazole and polybenzimidazole moieties 失效含有聚苯并恶唑，聚苯并噻唑和Polybenzimidazolabschnitte共聚物。
公开(公告)号：EP0368006B1
公开(公告)日：1995-04-05
申请号：EP89118821.1
申请日：1989-10-10
CPC分类号： C08G81/00 , C08G65/4012 , C08G73/18 , C08G73/22 , C08G75/32 , C08L71/00 , C08L2205/05 , C08L2666/20
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5.发明公开Phosphate salts of monomers for PBZ and their use in preparing PBZ polymers 失效PBZ单体的磷酸盐钠及其在制备PBZ聚合物中的用途
公开(公告)号：EP0393559A3
公开(公告)日：1991-08-14
申请号：EP90107177.9
申请日：1990-04-14
发明人： Harris, William J. , Kleiss, Luke Randall , Liu, Ming-Biann , Lysenko, Zenon , Rosenberg, Steven
IPC分类号： C08G73/06 , C08G73/18 , C08G73/22 , C08G75/32 , C07C211/64 , C07C215/90 , C07C323/34 , C07C211/50 , C07C215/80
CPC分类号： C07C323/34 , C07C215/80 , C08G73/18
摘要： PBZ polymers are synthesized by the reaction of AA- and BB-monomers. The BB-monomer is conveniently synthesized and isolated as a phosphate salt having a uniform number of phosphate ions associated with each BB-monomer ion. Such high purity monophosphate and diphosphate salts can be obtained by precipitating the monomer from an aqueous acid solution by adjusting the pH balance or from a mixture of phosphoric acid and a volatile, polar, saturated organic liquid at a relatively low temperature.
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6.发明公开Branched polybenzazole polymers and method of preparation 失效Vernetzte Polybenzazolpolymere und Verfahren zur Herstellung。
公开(公告)号：EP0415276A1
公开(公告)日：1991-03-06
申请号：EP90116207.3
申请日：1990-08-24
摘要： The invention is a process for making novel branched polybenzazole polymers and the polymers formed thereby. Novel compounds are also disclosed that are useful as branching agents in making the branched polybenzazole polymers. The branched polymers synthesized by the process can be formed into strong, light articles such as fibers and films.
摘要翻译： 本发明是制备新型支化聚吲哚聚合物的方法和由此形成的聚合物。 还公开了新颖的化合物，其可用作制备支链聚吲哚聚合物的支化剂。 通过该方法合成的支化聚合物可以形成强的轻质制品如纤维和薄膜。
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7.发明公开Phosphate salts of monomers for PBZ and their use in preparing PBZ polymers 失效磷脂on PBZ-Monomeren und ihre Verwendung zur Herstellung von PBZ-Polymeren。
公开(公告)号：EP0393559A2
公开(公告)日：1990-10-24
申请号：EP90107177.9
申请日：1990-04-14
发明人： Harris, William J. , Kleiss, Luke Randall , Liu, Ming-Biann , Lysenko, Zenon , Rosenberg, Steven
IPC分类号： C08G73/06 , C08G73/18 , C08G73/22 , C08G75/32 , C07C211/64 , C07C215/90 , C07C323/34 , C07C211/50 , C07C215/80
CPC分类号： C07C323/34 , C07C215/80 , C08G73/18
摘要： PBZ polymers are synthesized by the reaction of AA- and BB-monomers. The BB-monomer is conveniently synthesized and isolated as a phosphate salt having a uniform number of phosphate ions associated with each BB-monomer ion. Such high purity monophosphate and diphosphate salts can be obtained by precipitating the monomer from an aqueous acid solution by adjusting the pH balance or from a mixture of phosphoric acid and a volatile, polar, saturated organic liquid at a relatively low temperature.
摘要翻译： PBZ聚合物通过AA-和BB-单体的反应合成。 方便地合成和分离BB单体作为与每个BB-单体离子相关联的具有均匀数目的磷酸根离子的磷酸盐。 这样的高纯度单磷酸盐和二磷酸盐可以通过在相对低的温度下通过调节pH平衡或从磷酸和挥发性极性饱和有机液体的混合物中沉淀出酸水溶液中的单体而获得。
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公开(公告)号：EP1056860B1
公开(公告)日：2005-02-09
申请号：EP98910057.3
申请日：1998-02-25
发明人： Anderson, William Henry Kerr , Tempest, Philip R. , Carr, Frank J. , Harris, William J. , Armour, Kathryn
IPC分类号： C12N15/13 , C07K16/30 , C07K16/46 , C12N15/62 , C12N15/85 , A61K39/395 , A61K47/48 , A61K51/10 , G01N33/574 , G01N33/577
CPC分类号： C07K16/30 , A61K38/00 , A61K47/6851 , C07K2317/24 , C07K2319/00 , G01N33/57469
摘要： Novel humanized monoclonal antibodies, humanized antibody fragments, and derivatives thereof which specifically bind TAG-72 are provided as well as methods for their manufacture. These humanized antibodies are useful in the treatment of cancers which express TAG-72 as well as for diagnostic purposes, e.g., for in vivo imaging of tumors or cancer cells which express TAG-72.
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公开(公告)号：EP0476560B1
公开(公告)日：1995-05-17
申请号：EP91115673.5
申请日：1991-09-16
发明人： Lysenko, Zenon , Harris, William J.
CPC分类号： C08G75/32 , C08G73/18 , C08G73/22 , H05K1/0346
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公开(公告)号：EP0415276B1
公开(公告)日：1995-02-22
申请号：EP90116207.3
申请日：1990-08-24
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