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1.发明公开
公开(公告)号：EP1432453A1
公开(公告)日：2004-06-30
申请号：EP02757398.9
申请日：2002-08-27
发明人： KUNG, Hank, F. , KUNG, Mei-Ping , ZHUANG, Zhi-Ping
IPC分类号： A61K101/00 , A61K101/02
CPC分类号： C07C323/25 , A61K51/0478 , C07B2200/05 , C07C211/52 , C07C323/34 , C07C323/60 , C07D213/38 , C07D307/56 , C07D307/66 , C07D311/16 , C07D333/28
摘要： This invention relates to a method of imaging amyloid deposits and to labeled compounds, and methods of making labeled compounds useful in imaging amyloid deposits. This invention also relates to compounds, and methods of making compounds for inhibiting the aggregation of amyloid proteins to form amyloid deposits, and a method of delivering a therapeutic agent to amyloid deposits.
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公开(公告)号：EP0903340B1
公开(公告)日：2001-12-12
申请号：EP98121407.5
申请日：1995-03-17
发明人： Sugiyama, Tatsuo, c/o Ihara Chem. Ind. Co., Ltd. , Nakayama, Tadashi, c/o Ihara Chem. Ind. Co., Ltd.
IPC分类号： C07C319/14 , C07C323/52
CPC分类号： C07C319/14 , C07C319/06 , C07C323/52 , C07C323/34
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3.发明公开PROCEDE DE PREPARATION DE THIOLS AROMATIQUES ET DERIVES, REACTIFS, PRODUITS INTERMEDIAIRES ET LEUR PROCEDE D'OBTENTION 审中-公开工艺制备芳族衍生物和硫醇，试剂和中间产品及其生产
公开(公告)号：EP1042282A1
公开(公告)日：2000-10-11
申请号：EP98963591.7
申请日：1998-12-22
申请人： RHODIA CHIMIE
发明人： SPINDLER, Jean-Francis , DESMURS, Jean-Roger , BESLIN, Pierre , QUESNEL, Yannick , MISPELAERE, Clotilde
IPC分类号： C07C333/04 , C07C323/34 , C07C319/02 , C07C323/35 , C07C319/14
CPC分类号： C07C319/02 , C07B45/06 , C07C333/04 , C07C323/34
摘要： The invention concerns a method for preparing an aromatic thiol bearing an amino group from a hydroxylated compound bearing an amino group. The invention also concerns the starting reagents, the intermediate products such as an aromatic S-arylthiocarbamate and the method for obtaining them and the derived products such as thioethers. The invention concerns a method for the transposition of an O-arylthiocarbamate compound bearing at least one amino group into a S-arylthiocarbamate compound bearing at least one amino group, characterised in that it consists in heating an O-arylthiocarbamate compound bearing at least one amino group and an electroattractive group. The resulting S-arylthiocarbamate compound is used as intermediate for making an aromatic thiol or thioether.
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4.发明授权Bisaminothiophenol compound, process for producing the same and curing agent for fluorine-containing elastomer comprising the same 失效Bisaminothiophenolverbindung，固化剂处理它们的制造和这种化合物用于含氟弹性体
公开(公告)号：EP0712842B1
公开(公告)日：1998-12-30
申请号：EP95115263.6
申请日：1995-09-27
申请人： NIPPON MEKTRON, LTD.
IPC分类号： C07C323/34 , C07D277/82 , C08K5/37 , C08L27/12
CPC分类号： C07D277/82 , C07C323/34 , C08K5/37 , C08L27/12
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公开(公告)号：EP0612311A1
公开(公告)日：1994-08-31
申请号：EP92919948.0
申请日：1992-08-27
CPC分类号： C07C323/34 , C07C215/80 , C08G73/22 , C08G75/32
摘要： On précipite des sels contenant des ions de monomères AA-PBZ et des ions de monomères BB-PBZ à partir d'une solution aqueuse, en mettant en contact les sels solubles des monomères dans une solution aqueuse. On polymérise les sels de monomères à l'aide de techniques classiques pour former des polymères de polybenzazole sans recourir à la dévolatilisation et avec une régulation stoichiométrique très précise.
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6.发明授权Diphenylheteroalkylderivate, ihre Herstellung und daraus hergestellte Arzneimittel und Kosmetika 失效二氢异喹喔啉衍生物，其制备和药物和化妆品制剂
公开(公告)号：EP0386452B1
公开(公告)日：1993-09-22
申请号：EP90101944.8
申请日：1990-02-01
IPC分类号： C07C323/56 , C07C323/16 , C07C323/62 , C07C323/19 , C07C323/36 , C07C317/22 , C07C317/44 , C07C235/42 , C07C229/38 , C07C229/60 , C07C259/10
CPC分类号： C07F9/3834 , A61K8/33 , A61K8/34 , A61K8/36 , A61K8/37 , A61K8/40 , A61K8/411 , A61K8/42 , A61K8/445 , A61K8/46 , A61K8/671 , A61Q19/00 , C07C39/17 , C07C43/202 , C07C43/2055 , C07C43/21 , C07C43/23 , C07C45/44 , C07C47/575 , C07C59/70 , C07C65/24 , C07C65/26 , C07C69/76 , C07C69/92 , C07C205/34 , C07C205/37 , C07C211/60 , C07C217/48 , C07C217/58 , C07C217/76 , C07C217/86 , C07C223/06 , C07C229/38 , C07C229/60 , C07C233/18 , C07C233/25 , C07C233/43 , C07C233/47 , C07C233/75 , C07C255/54 , C07C259/10 , C07C309/42 , C07C317/22 , C07C317/32 , C07C317/44 , C07C323/16 , C07C323/19 , C07C323/20 , C07C323/32 , C07C323/34 , C07C323/36 , C07C323/41 , C07C323/56 , C07C323/62 , C07C327/30 , C07C2602/10 , C07F9/4021
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7.发明公开VERFAHREN ZUR HERSTELLUNG VON BIS(3-AMINOPHENYL)-DISULFIDEN UND 3-AMINOTHIOLEN 审中-公开VERFAHREN ZUR HERSTELLUNG VON BIS（3-AMINOPHENYL）-DISULIFIDEN UND 3-AMINOTHIOLEN
公开(公告)号：EP2931703A1
公开(公告)日：2015-10-21
申请号：EP13805850.8
申请日：2013-12-12
申请人： Bayer CropScience AG
IPC分类号： C07C319/06 , C07C319/22 , C07C319/24 , C07C323/09 , C07C323/34 , C07C323/37
CPC分类号： C07C319/06 , C07C319/22 , C07C319/24 , C07C323/09 , C07C323/34 , C07C323/35 , C07C323/37
摘要： The invention relates to a new method for producing bis(3-aminophenyl)disulfides of general formula (I) and 3-aminothiols of general formula (II), wherein X and Y have the meanings specified in the description, which are used as intermediate products for the production of insecticidally, acaricidally, and nematicidally active phenyl sulfoxides.
摘要翻译： 本发明涉及一种制备通式（I）的双（3-氨基苯基）二硫化物和通式（II）的3-氨基硫醇的新方法，其中X，Y具有说明书中所述的含义，其用于 作为制备具有杀虫，杀螨和杀线虫活性的苯基亚砜的中间体。
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8.发明授权
公开(公告)号：EP1432453B1
公开(公告)日：2013-08-14
申请号：EP02757398.9
申请日：2002-08-27
发明人： KUNG, Hank, F. , KUNG, Mei-Ping , ZHUANG, Zhi-Ping
IPC分类号： C07C211/52 , C07C323/34 , A61K51/04 , A61P25/28 , C07C323/60 , C07C323/25 , C07D213/38 , C07D311/16 , C07D333/28 , C07D307/56 , C07D307/66
CPC分类号： C07C323/25 , A61K51/0478 , C07B2200/05 , C07C211/52 , C07C323/34 , C07C323/60 , C07D213/38 , C07D307/56 , C07D307/66 , C07D311/16 , C07D333/28
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9.发明公开TETRAAZA- OR N2S2- COMPLEXANTS, AND THEIR USE IN RADIODIAGNOSTICS OR RADIOTHERAPY 失效四氮或N2S2复杂ANTEN，其使用无线电诊断或放疗
公开(公告)号：EP0971748A2
公开(公告)日：2000-01-19
申请号：EP98912032.4
申请日：1998-03-26
申请人： NEORX CORPORATION
发明人： KASINA, Sudhakar
IPC分类号： A61K49/00
CPC分类号： C07F13/005 , A61K51/04 , A61K51/0478 , A61K51/0482 , A61K51/0489 , A61K51/0497 , A61K51/087 , A61K51/088 , C07B2200/05 , C07C229/16 , C07C323/34 , C07D257/10 , C07D265/32 , C07D285/00 , C07D333/36 , C07D495/04 , C07D495/14 , C07F9/3817 , C07F9/6524 , C07F9/655345 , C07F9/6561
摘要： The present invention provides for substituted metal chelating compounds in which at least two of the chelating atoms are nitrogen which are directly attached to aromatic rings and one or more of those nitrogen atoms has attached thereto a substituent other than hydrogen, and methods for making and using these compounds. Another aspect of the invention provides for the use of the chelation compounds described above in methods for diagnostic and therapeutic purposes. A diagnostic method is described for detecting the presence or absence of a target site within a mammalian host. This method comprises providing to cells a diagnostically effective dose of a compound of the present invention which contains a metal radionuclide, such as 99mTc and/or 111In, and detecting the biodistribution of the radionuclide. A therapeutic method is described for delivering a radionuclide, such as ?186Re/188Re, 90Y, and 153¿Sm, to a target site within a mammalian host. This method comprises providing to cells a therapeutically effective dose of a chelate compound of the present invention.
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10.发明公开Process for production of alkoxycarbonylthioaryl compounds 失效Verfahren zur Herstellung von alkylcarbonylthioaryl Verbindungen
公开(公告)号：EP0903340A1
公开(公告)日：1999-03-24
申请号：EP98121407.5
申请日：1995-03-17
发明人： Sugiyama, Tatsuo, c/o Ihara Chem. Ind. Co., Ltd. , Nakayama, Tadashi, c/o Ihara Chem. Ind. Co., Ltd.
IPC分类号： C07C319/14 , C07C323/52
CPC分类号： C07C319/14 , C07C319/06 , C07C323/52 , C07C323/34
摘要： The present invention provides:
a process for producing an alkali metal salt of an arylmercaptan compound, represented by general formula (3):
which process comprises reacting a disulfide compound represented by general formula:
with a hydroxide of an alkali metal M 1 in the presence of a sulfur compound represented by general formula (2):
H (2-i) S(M 1 ) i (2)
a process for producing an alkoxycarbonylalkylthioaryl compound represented by general formula (5):
which process comprises reacting the above-mentioned alkalimetal salt of an arylmercaptan compound with a halogenofattyacid ester compound represented by general formula (4):
X 1 R 2 COOR 3 (4)
at pH 7-10; and
a process for producing the above-mentioned alkoxycarbonylalkylthioaryl compound, which process comprises reacting the above-mentioned disulfide compound with the above-mentioned hydroxide of an alkali metal M 1 in the presence of the above-mentioned sulfur compound to obtain an alkali metal salt of an arylmercaptan compound, and reacting said alkali metal salt, without isolating it, with the above-mentioned halogenofatty acid ester compound under the same condition as mentioned above.摘要翻译： 本发明提供：制备由通式（3）表示的芳基硫醇化合物的碱金属盐的方法：
该方法包括使通式为：CHEM的二硫化物与碱的氢氧化物反应 在由通式（2）表示的硫化合物存在下，金属M 1：H（2-i）S（M））用于制备由通式（5）表示的烷氧基羰基烷基硫代芳基化合物的方法：
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