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1.发明公开
公开(公告)号：EP1610813A1
公开(公告)日：2006-01-04
申请号：EP03716681.6
申请日：2003-03-19
发明人： GARDELLA, Thomas, J. , POTTS, John, T., Jr. , KRONENBERG, Henry, M. , SHIMIZU, Naoto, Chugai Pharmaceutical Co., Ltd , CARTER, Percy
IPC分类号： A61K38/29 , C07K1/06 , C07K14/635
CPC分类号： C07K14/635 , A61K38/29
摘要： The present invention relates to conformationally constrained parathyroid hormone (PTH) analogs and derivatives of those analogs. The invention also provides methods of preparing and using the PTH analogs. Further, the invention encompasses compositions and methods for use in limiting undesired bone loss in a vertebrate at risk of such bone loss, in treating conditions that are characterized by undesired bone loss or by the need for bone growth, e.g. in treating fractures or cartilage disorders and for raising camp levels in cells where deemed necessary.
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公开(公告)号：EP1606255B1
公开(公告)日：2009-11-11
申请号：EP04710294.2
申请日：2004-02-11
发明人： CHERNEY, Robert, J. , CARTER, Percy , DUNCIA, John, V. , GARDNER, Daniel, S. , SANTELLA, Joseph, B.
IPC分类号： C07D207/26 , C07D207/38 , C07D401/12 , C07D403/12 , C07D409/12 , C07D417/12 , A61K31/40 , A61P29/00
CPC分类号： C07D207/273 , C07D207/277 , C07D207/34 , C07D207/416 , C07D211/76 , C07D211/88 , C07D223/12 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/06 , C07D409/12 , C07D417/08 , C07D417/12 , C07D471/04 , C07D487/04 , C07D495/04
摘要： The present application describes modulators of MCP-1 of formula (I): [chemical structure] or pharmaceutically acceptable salt forms thereof, useful for the prevention of rheumatoid arthritis, multiple sclerosis, atherosclerosis and asthma, processes for preparing and intermediates thereof.
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公开(公告)号：EP1606255A2
公开(公告)日：2005-12-21
申请号：EP04710294.2
申请日：2004-02-11
发明人： CHERNEY, Robert, J. , CARTER, Percy , DUNCIA, John, V. , GARDNER, Daniel, S. , SANTELLA, Joseph, B.
IPC分类号： C07D207/50
CPC分类号： C07D207/273 , C07D207/277 , C07D207/34 , C07D207/416 , C07D211/76 , C07D211/88 , C07D223/12 , C07D401/12 , C07D403/04 , C07D403/12 , C07D405/06 , C07D409/12 , C07D417/08 , C07D417/12 , C07D471/04 , C07D487/04 , C07D495/04
摘要： The present application describes modulators of MCP-1 of formula (I): [chemical structure] or pharmaceutically acceptable salt forms thereof, useful for the prevention of rheumatoid arthritis, multiple sclerosis, atherosclerosis and asthma, processes for preparing and intermediates thereof.
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4.发明授权MALONAMIDES AND MALONAMIDE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY 有权丙二酰胺和丙二酰胺衍生物作为趋化因子受体活性的调节剂
公开(公告)号：EP1617803B1
公开(公告)日：2010-09-22
申请号：EP04751047.4
申请日：2004-04-30
发明人： CARTER, Percy
IPC分类号： C07C233/05 , C07C261/00 , A61K31/16 , A61K31/27 , A61P29/00 , A61P37/00 , A61P37/08
CPC分类号： C07D235/24 , C07C233/36 , C07C233/43 , C07C237/42 , C07C271/28 , C07C275/30 , C07D235/30 , C07D285/135
摘要： The present application describes modulators of MCP 1 of formula (I) or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma, multiple sclerosis, artherosclerosis, and rheumatoid arthritis.
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5.发明公开MALONAMIDES AND MALONAMIDE DERIVATIVES AS MODULATORS OF CHEMOKINE RECEPTOR ACTIVITY 有权丙二酰胺和丙二酰胺衍生物作为趋化因子受体活性的调节剂
公开(公告)号：EP1617803A2
公开(公告)日：2006-01-25
申请号：EP04751047.4
申请日：2004-04-30
发明人： CARTER, Percy
IPC分类号： A61K6/00
CPC分类号： C07D235/24 , C07C233/36 , C07C233/43 , C07C237/42 , C07C271/28 , C07C275/30 , C07D235/30 , C07D285/135
摘要： The present application describes modulators of MCP 1 of formula (I) or pharmaceutically acceptable salt forms thereof, useful for the prevention of asthma, multiple sclerosis, artherosclerosis, and rheumatoid arthritis.
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