专利检索 ap:("THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES") AND inv:"BUCHHOLZ, Ursula" 第 1 页

1.

发明公开
RECOMBINANT HUMAN METAPNEUMOVIRUS AND ITS USE 审中-公开
标题翻译：重组人类偏肺病毒及其用途

公开(公告)号：EP1603939A2

公开(公告)日：2005-12-14

申请号：EP04775808.1

申请日：2004-02-27

申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES

发明人： COLLINS, Peter, L. , BIACCHESI, Stephane , BUCHHOLZ, Ursula , SKIADOPOULOS, Mario, H. , MURPHY, Brian, R.

IPC分类号： C07K14/115 , C12N7/04 , C12N15/86 , A61K39/155

CPC分类号： A61K39/155 , A61K39/12 , A61K2039/5254 , A61K2039/5256 , A61K2039/70 , C12N7/00 , C12N15/86 , C12N2760/18334 , C12N2760/18343 , C12N2760/18351 , C12N2760/18361 , C12N2760/18362 , C12N2760/18634 , C12N2760/18643

摘要： Recombinant HMPV (rHMPV) and related immunogenic compositions and methods are provided. The rHMPVs, including chimeric and HMPV vector viruses, provided according to the current disclosure are infectious and attenuated in permissive mammalian subjects, including humans. The rHMPVs are useful in immunogenic compositions for eliciting an immune response against HPIV, against one or more non-HMPV pathogens, or against a HMPV and a non-HMPV pathogen. Also provided are isolated polynucloetide molecules and vectors incorporating a recombinant HMPV genome or antigenome.