公开(公告)号：EP3236998A1

公开(公告)日：2017-11-01

申请号：EP15831073.0

申请日：2015-12-24

申请人： The U.S.A. as represented by the Secretary, Department of Health and Human Services ,  Institute for Research in Biomedicine

发明人： KWONG, Peter ,  JOYCE, Michael Gordon ,  ZHANG, Baoshan ,  YANG, Yongping ,  COLLINS, Peter ,  BUCHHOLZ, Ursula ,  CORTI, Davide ,  LANZAVECCHIA, Antonio ,  STEWART-JONES, Guillaume

IPC分类号： A61K39/155 ,  C07K14/115 ,  A61K39/39 ,  A61K48/00 ,  C07K14/005 ,  C07K14/135 ,  C12N15/09

CPC分类号： A61K39/155 ,  A61K39/39 ,  A61K48/00 ,  C07K14/005 ,  C07K14/135 ,  C07K2319/70 ,  C07K2319/73 ,  C12N2760/18322 ,  C12N2760/18334 ,  C12N2760/18522 ,  C12N2760/18534

摘要： Metapneumovirus (MPV) F proteins stabilized in a prefusion conformation, nucleic acid molecules and vectors encoding these proteins, and methods of their use and production are disclosed. In several embodiments, the MPV F proteins and/or nucleic acid molecules can be used to generate an immune response to MPV in a subject. In additional embodiments, the therapeutically effective amount of the MPV F ectodomain trimers and/or nucleic acid molecules can be administered to a subject in a method of treating or preventing MPV infection.

摘要翻译： 披露了在融合前构象中稳定的偏肺病毒（MPV）F蛋白，编码这些蛋白的核酸分子和载体以及它们的使用和生产方法。 在几个实施方案中，MPV F蛋白和/或核酸分子可用于在受试者中产生对MPV的免疫应答。 在另外的实施方案中，治疗有效量的MPV F胞外域三聚体和/或核酸分子可以在治疗或预防MPV感染的方法中施用于受试者。

公开(公告)号：EP2494987A1

公开(公告)日：2012-09-05

申请号：EP11192999.8

申请日：2004-04-23

申请人： MedImmune Vaccines, Inc. ,  Vironovative BV

发明人： Haller, Aurelia ,  Tang, Roderick ,  Fouchier, Ronaldus Adrianus Maria ,  Van Den Hoogen, Bernadetta Gerarda ,  Osterhaus, Albertus Dominicus M.

IPC分类号： A61K39/155 ,  A61K39/295 ,  C12N7/00 ,  C12Q1/70 ,  C07K16/10

CPC分类号： C07K16/1027 ,  A61K39/00 ,  A61K39/12 ,  A61K39/155 ,  A61K2039/505 ,  A61K2039/543 ,  A61K2039/544 ,  A61K2039/70 ,  C07K14/005 ,  C07K2317/21 ,  C07K2317/23 ,  C12N7/00 ,  C12N2760/18321 ,  C12N2760/18322 ,  C12N2760/18334 ,  C12N2760/18343 ,  C12N2760/18351 ,  C12N2760/18361 ,  C12N2760/18534 ,  G01N2333/115

摘要： The present invention provides an isolated mammalian negative strand RNA virus, metapneumovirus (MPV), within the sub-family Pneumoviridae, of the family Paramyxoviridae. The invention also provides isolated mammalian negative strand RNA viruses identifiable as phylogenetically corresponding or relating to the genus Metapneumovirus and components thereof. In particular the invention provides a mammalian MPV, subgroups and variants thereof. The invention relates to genomic nucleotide sequences of different isolates of mammalian metapneumoviruses, in particular human metapneumoviruses. The invention relates to the use of the sequence information of different isolates of mammalian metapneumoviruses for diagnostic and therapeutic methods. The present invention relates to nucleotide sequences encoding the genome of a metapneumovirus or a portion thereof, including both mammalian and avian metapneumovirus. The invention further encompasses chimeric or recombinant viruses encoded by said nucleotide sequences. The invention also relates to chimeric and recombinant mammalian MPV that comprise one or more non-native or heterologous sequences. The invention further relates to vaccine formulations comprising mammalian or avian metapneumovirus, including recombinant and chimeric forms of said viruses. The vaccine preparations of the invention encompass multivalent vaccines, including bivalent and trivalent vaccine preparations. The invention also provide methods for propagating virus.

摘要翻译： 本发明提供了分离的哺乳动物负海滩RNA病毒，偏肺病毒（MPV），所述亚家族Pneumoviridae内时，副粘病毒科的。 因此本发明提供分离的哺乳动物负RNA病毒识别为系统发育海滩对应或与所述间质肺病毒属和其组分。 特别是本发明提供了哺乳动物MPV，分组和它们的变体。 本发明涉及不同分离株的哺乳动物间质肺病毒，特别是人类偏肺病毒基因组的核苷酸序列。 本发明涉及使用不同的分离物用于诊断和治疗方法的哺乳动物间质肺病毒的序列信息。 本发明涉及的核苷酸编码间质肺病毒的基因组或其部分，包括哺乳动物和鸟类间质肺病毒序列。 本发明还包括由所述核苷酸序列编码的嵌合或重组病毒。 因此，本发明涉及嵌合的和重组哺乳动物MPV确实包括一个或多个非天然的或异源序列。 本发明还涉及到疫苗配方和灰包含哺乳动物或禽类间质肺病毒，包括说病毒重组形式和嵌合形式。 本发明的疫苗制剂包含多价疫苗，包括二价和三价疫苗制剂。 因此，本发明提供一种用于繁殖病毒的方法。

公开(公告)号：EP2471926A2

公开(公告)日：2012-07-04

申请号：EP10197435.0

申请日：2010-12-30

申请人： Intervet International BV

发明人： The designation of the inventor has not yet been filed

IPC分类号： C12N15/117 ,  A61K39/39 ,  C12Q1/68 ,  A61K39/02 ,  A61K39/12 ,  A61P37/04

CPC分类号： A61K39/17 ,  A61K39/12 ,  A61K39/39 ,  A61K2039/552 ,  A61K2039/55561 ,  A61K2039/55566 ,  C12N15/117 ,  C12N2310/17 ,  C12N2310/315 ,  C12N2310/341 ,  C12N2310/345 ,  C12N2760/18134 ,  C12N2760/18334 ,  C12N2770/20034

摘要： The present invention relates to immunostimulatory oligodeoxynucleotides, vectors and vaccines comprising such oligodeoxynucleotides, to their use as a medicament, to their use in preventing or combating infectious disease, to methods for the detection of such oligodeoxynucleotides and to cells to be used in these methods.

摘要翻译： 本发明涉及免疫刺激性寡脱氧核苷酸，包含这种寡脱氧核苷酸的载体和疫苗，其用作药物，用于预防或防治传染病，用于检测这种寡脱氧核苷酸的方法和用于这些方法的细胞。

公开(公告)号：EP1485468A2

公开(公告)日：2004-12-15

申请号：EP03716118.9

申请日：2003-02-21

申请人： Medimmune Vaccines, Inc. ,  Vironovative B.V.

发明人： HALLER, Aurelia ,  TANG, Roderick ,  FOUCHIER, Ronaldus, Adrianus, Maria ,  VAN DEN HOGEN, Bernadetta, Gerarda ,  OSTERHAUS, Albertus, Dominicus, M.

IPC分类号： C12N7/00 ,  A61K39/12 ,  A61K39/15

CPC分类号： C12Q1/701 ,  A61K39/12 ,  A61K39/155 ,  A61K2039/5254 ,  A61K2039/5256 ,  A61K2039/545 ,  A61K2039/552 ,  A61K2039/58 ,  A61K2039/70 ,  A61K2123/00 ,  C07K14/005 ,  C07K16/1027 ,  C12N7/00 ,  C12N15/86 ,  C12N2710/22034 ,  C12N2760/18321 ,  C12N2760/18322 ,  C12N2760/18334 ,  C12N2760/18343 ,  C12N2760/18522 ,  C12N2760/18534 ,  C12N2760/18621 ,  C12N2760/18622 ,  C12N2760/18634 ,  C12N2760/18643 ,  C12N2840/203 ,  C12Q2600/158 ,  G01N33/5008 ,  G01N33/5011 ,  G01N33/502 ,  G01N33/5088 ,  G01N33/56983 ,  G01N2333/08 ,  Y02A90/26

摘要： The present invention relates to recombinant bovine parainfluenza virus (BPIV) cDNA or RNA which may be used to express heterologous gene products in appropriate host cell systems and/or to rescue negative strand RNA recombinant viruses that express, package, and/or present the heterologous gene product. In particular, the heterologous gene products include gene product of another species of PIV or from another negative strand RNA virus, including but not limited to, influenza virus, respiratory syncytial virus, human metapneumovirus and avian pneumovirus. The chimeric viruses and expression products may advantageously be used in vaccine formulations including vaccines against a broad range of pathogens and antigens.

摘要翻译： 本发明涉及可用于在合适的宿主细胞系统中表达异源基因产物的重组牛副流感病毒（BPIV）cDNA或RNA，和/或挽救表达，包装和/或呈递异源的负链RNA重组病毒 基因产物。 特别地，异源基因产物包括另一种PIV或另一种负链RNA病毒的基因产物，包括但不限于流感病毒，呼吸道合胞病毒，人偏肺病毒和禽肺病毒。 嵌合病毒和表达产物可有利地用于疫苗制剂中，包括针对各种病原体和抗原的疫苗。

公开(公告)号：EP2658974A1

公开(公告)日：2013-11-06

申请号：EP11802450.4

申请日：2011-12-29

申请人： Intervet International B.V.

发明人： SCHRIER, Carla Christina ,  ILG, Thomas Simon

IPC分类号： C12N15/117 ,  C12N5/10 ,  A61K39/39 ,  C12Q1/68 ,  A61K39/02 ,  A61K39/12 ,  A61P37/04

CPC分类号： A61K39/17 ,  A61K39/12 ,  A61K39/39 ,  A61K2039/552 ,  A61K2039/55561 ,  A61K2039/55566 ,  C12N15/117 ,  C12N2310/17 ,  C12N2310/315 ,  C12N2310/341 ,  C12N2310/345 ,  C12N2760/18134 ,  C12N2760/18334 ,  C12N2770/20034

摘要： The present invention relates to immunostimulatory oligodeoxynucleotides, vectors and vaccines comprising such oligodeoxynucleotides, to their use as a medicament, to their use in preventing or combating infectious disease, to methods for the detection of such oligodeoxynucleotides and to cells to be used in these method.

公开(公告)号：EP2471926A3

公开(公告)日：2012-07-11

申请号：EP10197435.0

申请日：2010-12-30

申请人： Intervet International BV

发明人： The designation of the inventor has not yet been filed

IPC分类号： C12N15/117 ,  A61K39/39 ,  C12Q1/68 ,  A61K39/02 ,  A61K39/12 ,  A61P37/04

CPC分类号： A61K39/17 ,  A61K39/12 ,  A61K39/39 ,  A61K2039/552 ,  A61K2039/55561 ,  A61K2039/55566 ,  C12N15/117 ,  C12N2310/17 ,  C12N2310/315 ,  C12N2310/341 ,  C12N2310/345 ,  C12N2760/18134 ,  C12N2760/18334 ,  C12N2770/20034

摘要： The present invention relates to immunostimulatory oligodeoxynucleotides, vectors and vaccines comprising such oligodeoxynucleotides, to their use as a medicament, to their use in preventing or combating infectious disease, to methods for the detection of such oligodeoxynucleotides and to cells to be used in these methods.

公开(公告)号：EP1185662B1

公开(公告)日：2011-03-02

申请号：EP00940474.0

申请日：2000-06-08

申请人： MERIAL

发明人： FISCHER, Laurent, Jean-Charles ,  BARZU-LE ROUX, Simona ,  AUDONNET, Jean-Christophe, Francis

IPC分类号： A61K39/175 ,  C12N15/38 ,  C12N15/27 ,  A61K48/00

CPC分类号： A61K39/265 ,  A61K39/12 ,  A61K39/155 ,  A61K39/175 ,  A61K39/245 ,  A61K39/27 ,  A61K2039/525 ,  A61K2039/53 ,  A61K2039/552 ,  A61K2039/70 ,  C07K14/535 ,  C07K2319/02 ,  C12N2710/16634 ,  C12N2710/16734 ,  C12N2760/18334 ,  C12N2760/18434 ,  C12N2760/18634

摘要： The invention aims at improving the efficacy and protection induced by DNA vaccination against viruses of the family of Paramyxoviridae and against the herpes virus, in pets and sport animals. The improvement of DNA vaccination is achieved either by formulating the vaccine with a cationic lipid containing a quaternary ammonium salt, DMRIE, or by modifications in the nucleotide sequence coding for the antigen of interest in particular of deletions of the fragment of the nucleotide sequence coding for the transmembrane domain of the antigen of interest, and/or insertions of introns and/or insertions of nucleotide sequences coding for the signal peptides, or by adding GM-CSF, or by combinations thereof. The invention also concerns the resulting vaccines.

公开(公告)号：EP1869225A4

公开(公告)日：2010-02-24

申请号：EP06738112

申请日：2006-03-09

申请人： MEDIMMUNE VACCINES INC

发明人： SCHICKLI JEANNE H

IPC分类号： C12N7/00 ,  A61K39/155 ,  C07K14/115

CPC分类号： C07K14/005 ,  A61K39/12 ,  A61K39/155 ,  A61K2039/525 ,  C12N7/00 ,  C12N2760/18321 ,  C12N2760/18322 ,  C12N2760/18334 ,  C12N2760/18343 ,  C12Q1/37 ,  C12Q1/701 ,  G01N2333/115

公开(公告)号：EP1523992A1

公开(公告)日：2005-04-20

申请号：EP04021994.1

申请日：1997-07-16

申请人： MERIAL

发明人： Audonnet, Jean-Christophe ,  Bouchardon, Annabelle ,  Riviere, Michel

IPC分类号： A61K39/12

CPC分类号： C07K14/005 ,  A61K39/12 ,  A61K39/145 ,  A61K39/155 ,  A61K39/17 ,  A61K39/215 ,  A61K39/245 ,  A61K39/255 ,  A61K2039/51 ,  A61K2039/53 ,  A61K2039/552 ,  A61K2039/70 ,  C12N2710/16034 ,  C12N2710/16334 ,  C12N2720/10034 ,  C12N2750/10034 ,  C12N2760/16134 ,  C12N2760/18134 ,  C12N2760/18334 ,  C12N2770/20034 ,  C12N2770/22034 ,  C12N2770/32034 ,  C12N2770/32434

摘要： La présente invention concerne des formules de vaccin aviaire contre la maladie de Gumboro.

摘要翻译： 本发明涉及用于冈博尔病的禽类疫苗制剂。

公开(公告)号：EP0914442B1

公开(公告)日：2004-09-22

申请号：EP97934579.0

申请日：1997-07-16

申请人： MERIAL

发明人： AUDONNET, Jean-Christophe ,  BOUCHARDON, Annabelle ,  RIVIERE, Michel

IPC分类号： C12N15/38 ,  C12N15/45 ,  C12N15/40 ,  C12N15/34 ,  C12N15/50 ,  C12N15/48 ,  C12N15/44 ,  A61K39/295

CPC分类号： C07K14/005 ,  A61K39/12 ,  A61K39/145 ,  A61K39/155 ,  A61K39/17 ,  A61K39/215 ,  A61K39/245 ,  A61K39/255 ,  A61K2039/51 ,  A61K2039/53 ,  A61K2039/552 ,  A61K2039/70 ,  C12N2710/16034 ,  C12N2710/16334 ,  C12N2720/10034 ,  C12N2750/10034 ,  C12N2760/16134 ,  C12N2760/18134 ,  C12N2760/18334 ,  C12N2770/20034 ,  C12N2770/22034 ,  C12N2770/32034 ,  C12N2770/32434

摘要： An avian vaccine formula including at least three polynucleotide vaccine valencies that each include a plasmid containing an avian pathogen valency gene capable of being expressed in vivo in host cells. Said valencies are selected from the group which consists of Marek's disease virus, Newcastle disease virus, infectious bursal disease virus, infectious bronchitis virus and infectious anaemia virus. The plasmids include one or more genes per valency, and said genes are selected from the group which consists of gB and gD for Marek's disease virus, HN and F for Newcastle disease virus, VP2 for infectious bursal disease virus, S, M and N for infectious bronchitis virus and C + NS1 for infectious anaemia virus.