公开(公告)号：EP0998567B1

公开(公告)日：2008-05-28

申请号：EP98935702.5

申请日：1998-07-16

申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES

发明人： YANAGI, Masayuki ,  BUKH, Jens ,  EMERSON, Suzanne, U. ,  PURCELL, Robert, H.

IPC分类号： C12N15/40 ,  C07K14/18 ,  C12Q1/70 ,  C07K16/10 ,  A61K39/29

CPC分类号： C07K14/005 ,  A61K39/00 ,  A61K2039/525 ,  C07K2319/00 ,  C12N7/00 ,  C12N2770/24221 ,  C12N2770/24222

摘要： The present invention discloses nucleic acid sequences which encode infectious hepatitis C viruses and the use of these sequences, and polypeptides encoded by all or part of these sequences, in the development of vaccines and diagnostics for HCV and in the development of screening assays for the identification of antiviral agents for HCV.

公开(公告)号：EP0662133A1

公开(公告)日：1995-07-12

申请号：EP93922703.0

申请日：1993-09-17

申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES

发明人： TSAREV, Sergei, A. ,  EMERSON, Suzanne, U. ,  PURCELL, Robert, H.

IPC分类号： G01N33 ,  A61K38 ,  A61K39 ,  A61P31 ,  A61P43 ,  C07H21 ,  C07K14 ,  C12N1 ,  C12N5 ,  C12N7 ,  C12N15 ,  C12P21

CPC分类号： C07K14/005 ,  A61K38/00 ,  A61K39/00 ,  C07H21/00 ,  C12N7/00 ,  C12N15/1131 ,  C12N2310/3125 ,  C12N2310/314 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/341 ,  C12N2310/345 ,  C12N2310/346 ,  C12N2710/14143 ,  C12N2770/28021 ,  C12N2770/28022 ,  C12N2770/28122 ,  C12N2770/28123 ,  Y10S977/802 ,  C12N2310/3521

摘要： A strain of hepatitis E virus from Pakistan (SAR-55) implicated in an epidemic of enterically transmitted non-A, non-B hepatitis, now called hepatitis E, is disclosed. The invention relates to the expression of the whole structural region of SAR-55, designated open reading frame 2 (ORF-2), in a eukaryotic expression system. The expressed protein is capable of forming HEV virus-like particles which can serve as an antigen in diagnostic immunoassays and as an immunogen or vaccine to protect against infection by hepatitis E.

公开(公告)号：EP0662133B1

公开(公告)日：2009-11-18

申请号：EP93922703.9

申请日：1993-09-17

申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES

发明人： TSAREV, Sergei, A. ,  EMERSON, Suzanne, U. ,  PURCELL, Robert, H.

IPC分类号： C12N15/51 ,  C12N7/00 ,  C12N15/40 ,  A61K39/29 ,  G01N33/576

CPC分类号： C07K14/005 ,  A61K38/00 ,  A61K39/00 ,  C07H21/00 ,  C12N7/00 ,  C12N15/1131 ,  C12N2310/3125 ,  C12N2310/314 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/341 ,  C12N2310/345 ,  C12N2310/346 ,  C12N2710/14143 ,  C12N2770/28021 ,  C12N2770/28022 ,  C12N2770/28122 ,  C12N2770/28123 ,  Y10S977/802 ,  C12N2310/3521

公开(公告)号：EP0784631B1

公开(公告)日：2011-08-03

申请号：EP95936312.8

申请日：1995-10-03

申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES

发明人： TSAREV, Sergei, A. ,  EMERSON, Suzanne, U. ,  PURCELL, Robert, H.

IPC分类号： C07K14/08 ,  C12N15/51 ,  A61K39/29 ,  G01N33/576 ,  C12Q1/70

CPC分类号： C07K14/005 ,  A61K39/00 ,  C12N2770/28122 ,  C12N2770/28123

摘要： A strain of hepatitis E virus from Pakistan (SAR-55) implicated in an epidemic of enterically transmitted non-A, non-B hepatitis, now called hepatitis E, is disclosed. The invention relates to the expression of the whole structural region of SAR-55, designated open reading frame 2 (ORF-2), in a eukaryotic expression system. The expressed protein is capable of forming HEV virus-like particles which can serve as an antigen in diagnostic immunoassays and as an immunogen or vaccine to protect against infection by hepatitis E.

公开(公告)号：EP0972048B1

公开(公告)日：2008-03-12

申请号：EP98919756.1

申请日：1998-04-09

申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES

发明人： EMERSON, Suzanne, U. ,  PURCELL, Robert, H. ,  TSAREV, Sergei A. ,  ROBINSON, Robin, A.

IPC分类号： C12N15/51 ,  C07K14/08 ,  C07K16/10 ,  A61K39/29 ,  G01N33/576

CPC分类号： C07K14/005 ,  A61K39/00 ,  C12N2770/28122 ,  G01N2333/08

公开(公告)号：EP1355947A2

公开(公告)日：2003-10-29

申请号：EP01989143.1

申请日：2001-11-30

申请人： The Government of the United States of America, as Represented by the Secretary, Department of Health and Human Services

发明人： SCHOFIELD, Darren ,  EMERSON, Suzanne, U. ,  PURCELL, Robert, H. ,  ALTER, Harvey, J.

IPC分类号： C07K16/10 ,  C12N15/13 ,  A61K39/42 ,  G01N33/577 ,  G01N33/569 ,  C07K16/42

CPC分类号： G01N33/6878 ,  A61K2039/505 ,  C07K16/109 ,  C07K16/4216 ,  C07K2317/21 ,  C07K2317/55 ,  C07K2317/565 ,  G01N33/5767 ,  G01N2333/18

摘要： The present invention describes the identification and characterization of five human HC E2-specific monoclonal antibodies isolated form a phage display library and their use in the diagnosis, treatment, and prevention of HCV in mammals, preferably humans.

公开(公告)号：EP0784631A1

公开(公告)日：1997-07-23

申请号：EP95936312.0

申请日：1995-10-03

申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES

发明人： TSAREV, Sergei, A. ,  EMERSON, Suzanne, U. ,  PURCELL, Robert, H.

IPC分类号： G01N33 ,  A61K35 ,  A61K39 ,  A61K48 ,  A61P31 ,  C07K14 ,  C07K16 ,  C12N1 ,  C12N5 ,  C12N7 ,  C12N15 ,  C12P21 ,  C12R1

CPC分类号： C07K14/005 ,  A61K39/00 ,  C12N2770/28122 ,  C12N2770/28123

摘要： A strain of hepatitis E virus from Pakistan (SAR-55) implicated in an epidemic of enterically transmitted non-A, non-B hepatitis, now called hepatitis E, is disclosed. The invention relates to the expression of the whole structural region of SAR-55, designated open reading frame 2 (ORF-2), in a eukaryotic expression system. The expressed protein is capable of forming HEV virus-like particles which can serve as an antigen in diagnostic immunoassays and as an immunogen or vaccine to protect against infection by hepatitis E.