公开(公告)号：EP0880701A1

公开(公告)日：1998-12-02

申请号：EP96929056.0

申请日：1996-08-21

申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA, as represented by THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES

发明人： KOHN, Leonard ,  SINGER, Dinah, S. ,  SAJI, Motoyasu ,  GIULIANI, Cesidio ,  SHONG, Minho ,  SUZUKI, Koichi ,  OHMORI, Masayuki

IPC分类号： C12N15 ,  A61K31 ,  A61K48 ,  A61P37 ,  C07K14 ,  C07K16 ,  C12P21 ,  C12Q1 ,  G01N33 ,  C12R1

CPC分类号： G01N33/68 ,  C07K14/4702 ,  C07K14/4713 ,  C07K14/70539 ,  C12Q1/68 ,  C12Q1/6897

摘要： The present invention provides methods for treating autoimmune diseases in mammals and for preventing or treating transplantation rejection in a transplant recipient. The methods of treatment involve the use of drugs capable of suppressing expression of MHC Class I molecules. In particular the use of the drug methimazole to suppress expression of MHC Class I molecules in the treatment of autoimmune diseases and the prevention or treatment of rejection in a transplant recipient is disclosed. In addition in vivo and in vitro assays are provided for the assessment and development of drugs capable of suppressing MHC Class I molecules. In addition, this invention relates to nucleic acid and amino acid sequences for proteins capable of modulating MHC Class I expression.