公开(公告)号：EP2336174B1

公开(公告)日：2015-06-03

申请号：EP10180621.4

申请日：2005-11-04

申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by the SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES

发明人： Dimitrov, Diviter S ,  Zhu, Zhongyu ,  Broder, Christopher C

IPC分类号： C07K16/10 ,  A61K39/395

CPC分类号： C07K16/1203 ,  A61K51/1009 ,  A61K2039/505 ,  C07K16/1027 ,  C07K2317/21 ,  C07K2317/51 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/56983 ,  G01N33/6893 ,  G01N2333/115 ,  G01N2469/10

公开(公告)号：EP2336174A3

公开(公告)日：2012-07-04

申请号：EP10180621.4

申请日：2005-11-04

申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by the SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES

发明人： Dimitrov, Diviter S ,  Zhu, Zhongyu ,  Broder, Christopher C

IPC分类号： C07K16/10 ,  A61K39/395

CPC分类号： C07K16/1203 ,  A61K51/1009 ,  A61K2039/505 ,  C07K16/1027 ,  C07K2317/21 ,  C07K2317/51 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/56983 ,  G01N33/6893 ,  G01N2333/115 ,  G01N2469/10

摘要： The present invention relates to monoclonal antibodies that bind or neutralize Hendra or Nipah virus The invention provides such antibodies, fragments of such antibodies retaining Hendra or Nipah virus-binding ability, fully human antibodies retaining Hendra or Nipah virus-binding ability, and pharmaceutical compositions including such antibodies The invention further provides for isolated nucleic acids encoding the antibodies of the invention and host cells transformed therewith. Additionally, the invention provides for prophylactic, therapeutic, and diagnostic methods employing the antibodies and nucleic acids of the invention

公开(公告)号：EP2336174B8

公开(公告)日：2015-09-23

申请号：EP10180621.4

申请日：2005-11-04

申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by the SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES ,  The Henry M. Jackson Foundation for the Advancement of Military Medicine, Inc.

发明人： Dimitrov, Diviter S ,  Zhu, Zhongyu ,  Broder, Christopher C

IPC分类号： C07K16/10 ,  A61K39/395

CPC分类号： C07K16/1203 ,  A61K51/1009 ,  A61K2039/505 ,  C07K16/1027 ,  C07K2317/21 ,  C07K2317/51 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/56983 ,  G01N33/6893 ,  G01N2333/115 ,  G01N2469/10

公开(公告)号：EP2336174A2

公开(公告)日：2011-06-22

申请号：EP10180621.4

申请日：2005-11-04

申请人： THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by the SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES

发明人： Dimitrov, Diviter S ,  Zhongyu, Zhu ,  Broder, Christopher C

IPC分类号： C07K16/10 ,  A61K39/395

CPC分类号： C07K16/1203 ,  A61K51/1009 ,  A61K2039/505 ,  C07K16/1027 ,  C07K2317/21 ,  C07K2317/51 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/56983 ,  G01N33/6893 ,  G01N2333/115 ,  G01N2469/10

摘要： The present invention relates to monoclonal antibodies that bind or neutralize Hendra or Nipah virus The invention provides such antibodies, fragments of such antibodies retaining Hendra or Nipah virus-binding ability, fully human antibodies retaining Hendra or Nipah virus-binding ability, and pharmaceutical compositions including such antibodies The invention further provides for isolated nucleic acids encoding the antibodies of the invention and host cells transformed therewith. Additionally, the invention provides for prophylactic, therapeutic, and diagnostic methods employing the antibodies and nucleic acids of the invention