专利检索 ap:("THE JOHNS HOPKINS UNIVERSITY" OR "IMPERIAL CHEMICAL INDUSTRIES PLC" OR "THE UNIVERSITY OF UTAH" OR "THE CANCER INSTITUTE OF JAPANESE FOUNDATION FOR CANCER RESEARCH") AND inv:"CARLSON, Mary, L." 第 1 页

1.

发明公开
INHERITED AND SOMATIC MUTATIONS OF APC GENE IN COLORECTAL CANCER OF HUMANS 失效
标题翻译：继承和APC基因在大肠癌中的体细胞突变。

公开(公告)号：EP0569527A1

公开(公告)日：1993-11-18

申请号：EP92906080.0

申请日：1992-01-16

申请人： THE JOHNS HOPKINS UNIVERSITY , IMPERIAL CHEMICAL INDUSTRIES PLC , THE UNIVERSITY OF UTAH , THE CANCER INSTITUTE OF JAPANESE FOUNDATION FOR CANCER RESEARCH

发明人： KINZLER, Kenneth, W. , VOGELSTEIN, Bert , ANAND, Rakesh , HEDGE, Philip, John , MARKHAM, Alexander, Fred , ALBERTSEN, Hans , CARLSON, Mary, L. , GRODEN, Joanna, L. , JOSLYN, Geoff , THLIVERIS, Andrew , WHITE, Raymond, L. , NAKAMURA, Yusuke

IPC分类号： C07K14 , C12N15 , C12Q1

CPC分类号： C12Q1/6827 , C07K14/47 , C12Q1/68 , C12Q1/6886 , C12Q2600/118 , C12Q2600/136

摘要： L'invention décrit un gène humain dénommé APC, ainsi que des procédés et des kits servant à évaluer les mutations du gène APC dans les tissus et les échantillons corporels de l'homme. On trouve des mutations du gène APC chez les patients atteints de polypose adénomateuse héréditaire, ainsi que chez des patients atteints de cancer recto-colique sporadique. APC est exprimé dans la plupart des tissus normaux. Ces résultats font supposer que le gène APC est un suppresseur de tumeur.

2.

发明授权
INHERITED AND SOMATIC MUTATIONS OF APC GENE IN COLORECTAL CANCER OF HUMANS 失效
标题翻译：继承和APC基因在大肠癌中的体细胞突变

公开(公告)号：EP0569527B1

公开(公告)日：2001-03-14

申请号：EP92906080.4

申请日：1992-01-16

申请人： THE JOHNS HOPKINS UNIVERSITY , ZENECA LIMITED , THE UNIVERSITY OF UTAH , JAPANESE FOUNDATION FOR CANCER RESEARCH

发明人： KINZLER, Kenneth, W. , VOGELSTEIN, Bert , ANAND, Rakesh , HEDGE, Philip, John , MARKHAM, Alexander, Fred , ALBERTSEN, Hans , CARLSON, Mary, L. , GRODEN, Joanna, L. , JOSLYN, Geoff , THLIVERIS, Andrew , WHITE, Raymond, L. , NAKAMURA, Yusuke

IPC分类号： C12Q1/68 , C12N15/12

CPC分类号： C12Q1/6827 , C07K14/47 , C12Q1/68 , C12Q1/6886 , C12Q2600/118 , C12Q2600/136

摘要： A human gene termed APC is disclosed. Methods and kits are provided for assessing mutations of the APC gene in human tissues and body samples. APC mutations are found in familial adenomatous polyposis patients as well as in sporadic colorectal cancer patients. APC is expressed in most normal tissues. These results suggest that APC is a tumor suppressor.