公开(公告)号：EP1773384A2

公开(公告)日：2007-04-18

申请号：EP05856778.5

申请日：2005-06-01

申请人： THE MOUNT SINAI SCHOOL OF MEDICINE, OF THE CITY UNIVERSITY OF NEW YORK ,  ST. JUDE CHILDREN'S RESEARCH HOSPITAL ,  The United States of America as represented by the secretary of Agriculture

发明人： GARCIA-SASTRE, Adolfo ,  PALESE, Peter ,  LAGER, Kelly, M. ,  WEBSTER, Robert ,  RICHT, Juergen, A. ,  WEBBY, Richard, J.

IPC分类号： A61K39/00 ,  A61K39/12 ,  A61K39/145 ,  C12N15/64 ,  C12N5/00 ,  A61K39/116

CPC分类号： A61K39/145 ,  A61K39/12 ,  A61K2039/5254 ,  A61K2039/5256 ,  A61K2039/544 ,  A61K2039/552 ,  A61K2039/58 ,  C12N7/00 ,  C12N2760/16034 ,  C12N2760/16061 ,  C12N2760/16121 ,  C12N2760/16134 ,  C12N2760/16151 ,  C12N2760/16171

摘要： The present invention relates, in general, to attenuated swine influenza viruses having an impaired ability to antagonize the cellular interferon (IFN) response, and the use of such attenuated viruses in vaccine and pharmaceutical formulations. In particular, the invention relates to attenuated swine influenza viruses having modifications to a swine NS1 gene that diminish or eliminate the ability of the NS1 gene product to antagonize the cellular IFN response. These viruses replicate in vivo, but demonstrate decreased replication, virulence and increased attenuation, and therefore are well suited for use in live virus vaccines, and pharmaceutical formulations.

摘要翻译： 本发明一般涉及具有拮抗细胞干扰素（IFN）应答能力受损的减毒猪流感病毒，以及在疫苗和药物制剂中使用这种减毒病毒。 具体地，本发明涉及具有修饰的猪NS1基因的减毒猪流感病毒，其减少或消除NS1基因产物拮抗细胞IFN应答的能力。 这些病毒在体内复制，但表现出降低的复制，毒力和增加的衰减，因此非常适合用于活病毒疫苗和药物制剂。

公开(公告)号：EP1773384B1

公开(公告)日：2015-08-12

申请号：EP05856778.5

申请日：2005-06-01

申请人： Icahn School of Medicine at Mount Sinai ,  ST. JUDE CHILDREN'S RESEARCH HOSPITAL ,  The United States of America as represented by the Secretary of Agriculture

发明人： GARCIA-SASTRE, Adolfo ,  PALESE, Peter ,  LAGER, Kelly, M. ,  WEBSTER, Robert ,  RICHT, Juergen, A. ,  WEBBY, Richard, J.

IPC分类号： A61K39/00 ,  A61K39/12 ,  A61K39/145 ,  C12N15/64 ,  C12N5/00 ,  A61K39/116

CPC分类号： A61K39/145 ,  A61K39/12 ,  A61K2039/5254 ,  A61K2039/5256 ,  A61K2039/544 ,  A61K2039/552 ,  A61K2039/58 ,  C12N7/00 ,  C12N2760/16034 ,  C12N2760/16061 ,  C12N2760/16121 ,  C12N2760/16134 ,  C12N2760/16151 ,  C12N2760/16171