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公开(公告)号：EP0723579A1
公开(公告)日：1996-07-31
申请号：EP94931872.0
申请日：1994-10-13
发明人： BAECK, André , GHOSH, Chanchal, Kumar , GRAYCAR, Thomas, Paul , BOTT, Richard, Ray , WILSON, Lori, Jean , BRODE, Philip, Frederick, III , BARNETT, Bobby, Lee , RUBINGH, Donn, Nelton
CPC分类号： A61K8/416 , A61K8/22 , A61K8/23 , A61K8/24 , A61K8/42 , A61K8/463 , A61K8/466 , A61K8/49 , A61K8/4906 , A61K8/66 , A61K2800/222 , A61K2800/86 , A61Q11/00 , A61Q11/02 , A61Q19/10 , C11D3/386 , C12N9/54 , G06Q40/04
摘要： The present invention relates to cleaning compositions comprising protease enzyme which is a carbonyl hydrolase variant having an amino acid sequence not found in nature, which is derived by replacement of a plurality of amino acid residues of a precursor carbonyl hydrolase with different amino acids, wherein said plurality of amino acid residues replaced in the precursor enzyme correspond to position +76 in combination with one or more of the following residues: +99, +101, +103, +104, +107, +123, +27, +105, +109, +126, +128, +135, +156, +166, +195, +197, +204, +206, +210, +216, +217, +218, +222, +260, +265, and/or +274, where the numbered positions correspond to naturally-occurring subtilisin from Bacillus amyloliquefaciens or to equivalent amino acid residues in other carbonyl hydrolases or subtilisins (such as Bacillus lentus subtilisin).
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2.发明公开FABRIC CLEANING COMPOSITIONS CONTAINING SUBTILISIN BPN' VARIANTS 失效SUBTILISIM BPN“变异含织物REININGHAUS组合物
公开(公告)号：EP0758373A1
公开(公告)日：1997-02-19
申请号：EP95916426.0
申请日：1995-04-17
发明人： BRODE, Philip, Frederick, III , BARNETT, Bobby, Lee , RUBINGH, Donn, Nelton , GHOSH, Chanchal, Kamur
CPC分类号： C12N9/54 , C11D3/38609
摘要： The present invention relates to fabric cleaning compositions comprising subtilisin BPN' variants, wherein the BPN' variant comprises one or more amino acid positions having a different amino acid than that occurring in wild-type subtilisin BPN' (i.e., substitution) at specifically identified positions, whereby the BPN' variant has decreased adsorption to, and increased hydrolysis of, an insoluble substrate as compared to wild-type subtilisin BPN'.
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3.发明公开SUBTILISIN 309 VARIANTS HAVING DECREASED ADSORPTION AND INCREASED HYDROLYSIS 失效枯草杆菌蛋白酶具有降低吸附和增加的水解309个OPTIONS
公开(公告)号：EP0758389A1
公开(公告)日：1997-02-19
申请号：EP95916446.0
申请日：1995-04-18
发明人： BRODE, Philip, Frederick, III , BARNETT, Bobby, Lee , RUBINGH, Donn, Nelton , GHOSH, Chanchal, Kamur
CPC分类号： C12N9/54 , A61K8/22 , A61K8/23 , A61K8/24 , A61K8/416 , A61K8/42 , A61K8/463 , A61K8/466 , A61K8/49 , A61K8/4906 , A61K8/66 , A61K2800/222 , A61K2800/86 , A61Q11/00 , A61Q11/02 , A61Q19/10 , C11D3/386 , G06Q40/04
摘要： The present invention relates to subtilisin (309) variants having a modified amino acid sequence of wild-type subtilisin (309) amino acid sequence, the wild-type amino acid sequence comprising a first loop region, a second loop region, a third loop region, a fourth loop region, a fifth loop region and a sixth loop region; wherein the modified amino acid sequence comprises different amino acids than that occurring in wild-type subtilisin (309) (i.e., substitution) at specifically identified positions in one or more of the loop regions whereby the subtilisin (309) variant has decreased adsorption to, and increased hydrolysis of, an insoluble substrate as compared to the wild type subtilisin (309). The present invention also relates to DNA sequence encoding such subtilisin (309) variants. The present invention also relates to compositions comprising such subtilisin (309) variants for cleaning a variety of surfaces.
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4.发明公开SUBTILISIN BPN' VARIANTS WITH DECREASED ADSORPTION AND INCREASED HYDROLYSIS 失效枯草杆菌蛋白酶BPN“具有降低吸附和增加的水解选项
公开(公告)号：EP0719339A1
公开(公告)日：1996-07-03
申请号：EP94929758.0
申请日：1994-08-31
CPC分类号： C12N9/54 , A61K8/66 , A61Q11/00 , C11D3/38609
摘要： The present invention relates to subtilisin BPN' variants comprising at least one or more amino acid positions having a different amino acid than that occurring in wild-type subtilisin BPN' (i.e., substitution) at positions 199-220 whereby the BPN' variant has decreased adsorption to, and increased hydrolysis of, an insoluble substrate as compared to wild-type subtilisin BPN'.
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公开(公告)号：EP0723579B1
公开(公告)日：2007-05-02
申请号：EP94931872.9
申请日：1994-10-13
发明人： BAECK, André , GHOSH, Chanchal, Kumar , GRAYCAR, Thomas, Paul , BOTT, Richard, Ray , WILSON, Lori, Jean , BRODE, Philip, Frederick, III , BARNETT, Bobby, Lee , RUBINGH, Donn, Nelton
CPC分类号： A61K8/416 , A61K8/22 , A61K8/23 , A61K8/24 , A61K8/42 , A61K8/463 , A61K8/466 , A61K8/49 , A61K8/4906 , A61K8/66 , A61K2800/222 , A61K2800/86 , A61Q11/00 , A61Q11/02 , A61Q19/10 , C11D3/386 , C12N9/54 , G06Q40/04
摘要： The present invention relates to cleaning compositions comprising protease enzyme which is a carbonyl hydrolase variant having an amino acid sequence not found in nature, which is derived by replacement of a plurality of amino acid residues of a precursor carbonyl hydrolase with different amino acids, wherein said plurality of amino acid residues replaced in the precursor enzyme correspond to position +76 in combination with one or more of the following residues: +99, +101, +103, +104, +107, +123, +27, +105, +109, +126, +128, +135, +156, +166, +195, +197, +204, +206, +210, +216, +217, +218, +222, +260, +265, and/or +274, where the numbered positions correspond to naturally-occurring subtilisin from Bacillus amyloliquefaciens or to equivalent amino acid residues in other carbonyl hydrolases or subtilisins (such as Bacillus lentus subtilisin).
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6.发明公开SUBTILISIN BPN' VARIANTS HAVING DECREASED ADSORPTION AND INCREASED HYDROLYSIS 失效枯草杆菌蛋白酶BPN“具有降低吸附和增加的水解选项
公开(公告)号：EP0758388A1
公开(公告)日：1997-02-19
申请号：EP95914713.0
申请日：1995-03-16
发明人： BRODE, Philip, Frederick, III , BARNETT, Bobby, Lee , RUBINGH, Donn, Nelton , GHOSH, Chanchal, Kumar
CPC分类号： C11D3/38609 , A61K8/66 , A61Q11/00 , C11D3/386 , C12N9/54
摘要： The present invention relates to subtilisin BPN' variants having a modified amino acid sequence of wild-type BPN' amino acid sequence, the wild-type amino acid sequence comprising a first loop region, a second loop region, a third loop region, a fourth loop region and a fifth loop region; wherein the modified amino acid sequence comprises different amino acids than that occurring in wild-type subtilisin BPN' (i.e., substitution) at specifically identified positions in one or more of the loop regions whereby the BPN' variant has decreased adsorption to, and increased hydrolysis of, an insoluble substrate as compared to the wild-type subtilisin BPN'. The present invention also relates to the genes encoding such subtilisin BPN' variants. The present invention also relates to compositions comprising such subtilisin BPN' variants for cleaning a variety of surfaces.
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公开(公告)号：EP0723580A1
公开(公告)日：1996-07-31
申请号：EP95903507.0
申请日：1994-10-13
发明人： BURNS, Michael, Eugene , GHOSH, Chanchal, Kumar , DIGIULIO, David, Neil , GETTY, Edward, Eugene , WILLEY, Alan, David , HARTSHORN, Richard Timothy, Hersham Close , BRODE, Philip, Frederick, III , BARNETT, Bobby, Lee , RUBINGH, Donn, Nelton
CPC分类号： A61K8/24 , A61K8/22 , A61K8/23 , A61K8/416 , A61K8/42 , A61K8/463 , A61K8/466 , A61K8/49 , A61K8/4906 , A61K8/66 , A61K2800/222 , A61K2800/86 , A61Q11/00 , A61Q11/02 , A61Q19/10 , C11D3/386 , C11D3/3907 , C11D3/3917 , G06Q40/04
摘要： The invention herein provides bleaching compositions comprising a protease enzyme which is a carbonyl hydrolase variant having an amino acid sequence not found in nature, which is derived by replacement of a plurality of amino acid residues of a precursor carbonyl hydrolase with different amino acids, wherein said plurality of amino acid residues replaced in the precursor enzyme correspond to position +76 in combination with one or more of the following residues: +99, +101, +103, +104, +107, +123, +27, +105, +109, +126, +128, +135, +156, +166, +195, +197, +204, +206, +210, +216, +217, +218, +222, +260, +265, and/or +274, where the numbered positions correspond to naturally-occurring subtilisin from Bacillus amyloliquefaciens or to equivalent amino acid residues in other carbonyl hydrolases or subtilisins (such as Bacillus lentus subtilisin) and a bleaching agent.
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8.发明授权SUBTILISIN BPN' VARIANTS WITH DECREASED ADSORPTION AND INCREASED HYDROLYSIS 失效枯草杆菌蛋白酶BPN“具有降低吸附和增加的水解选项
公开(公告)号：EP0719339B1
公开(公告)日：2006-10-25
申请号：EP94929758.4
申请日：1994-08-31
CPC分类号： C12N9/54 , A61K8/66 , A61Q11/00 , C11D3/38609
摘要： The present invention relates to subtilisin BPN' variants comprising at least one or more amino acid positions having a different amino acid than that occurring in wild-type subtilisin BPN' (i.e., substitution) at positions 199-220 whereby the BPN' variant has decreased adsorption to, and increased hydrolysis of, an insoluble substrate as compared to wild-type subtilisin BPN'.
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公开(公告)号：EP0723580B1
公开(公告)日：2003-07-16
申请号：EP95903507.2
申请日：1994-10-13
发明人： BURNS, Michael, Eugene , GHOSH, Chanchal, Kumar , DIGIULIO, David, Neil , GETTY, Edward, Eugene , WILLEY, Alan, David , HARTSHORN, Richard Timothy, Hersham Close , BRODE, Philip, Frederick, III , BARNETT, Bobby, Lee , RUBINGH, Donn, Nelton
CPC分类号： A61K8/24 , A61K8/22 , A61K8/23 , A61K8/416 , A61K8/42 , A61K8/463 , A61K8/466 , A61K8/49 , A61K8/4906 , A61K8/66 , A61K2800/222 , A61K2800/86 , A61Q11/00 , A61Q11/02 , A61Q19/10 , C11D3/386 , C11D3/3907 , C11D3/3917 , G06Q40/04
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10.发明公开THERMITASE VARIANTS HAVING DECREASED ADSORPTION AND INCREASED HYDROLYSIS 失效具有降低吸附和增加的水解Thermitase OPTIONS
公开(公告)号：EP0815244A1
公开(公告)日：1998-01-07
申请号：EP96908663.0
申请日：1996-03-06
CPC分类号： C11D3/386 , A61K8/66 , A61Q11/00 , C11D3/0078 , C12N9/52
摘要： The present invention relates to Thermitase variants having a modified amino acid sequence of wild-type Thermitase amino acid sequence, the wild-type amino acid sequence comprising a first loop region, a second loop region, a third loop region, a fourth loop region, a fifth loop region and a sixth loop region; wherein the modified amino acid sequence comprises different amino acids than that occurring in wild-type Thermitase (i.e., substitution) at specifically identified positions in one or more of the loop regions whereby the Thermitase variant has decreased adsorption to, and increased hydrolysis of, an insoluble substrate as compared to the wild-type Thermitase. The present invention also relates to DNA sequences encoding such Thermitase variants. The present invention also relates to compositions comprising such Thermitase variants for cleaning a variety of surfaces.
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