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公开(公告)号:EP1682551A2
公开(公告)日:2006-07-26
申请号:EP04810572.0
申请日:2004-11-09
发明人: CLARK, Michael, Philip , LAUGHLIN, Steven, Karl , GOLEBIOWSKI, Adam , BRUGEL, Todd, Andrew , SABAT, Mark
IPC分类号: C07D487/00 , A61K31/4162 , A61P29/00
CPC分类号: C07D487/04
摘要: The present invention relates to 6,7-dihydro-5H-pyrazolo[1,2a]pyrazol-1-ones which inhibit the extracellular release of inflammatory cytokines, said cytokines responsible for one or more human or higher mammalian disease states. The present invention further relates to compositions comprising said 6,7-dihydro-5H-pyrazolo[1,2a]pyrazol-1-ones and methods for preventing, abating, or otherwise controlling enzymes which are understood to be the active components responsible for the herein described disease states.