专利检索 ap:("THE PROVOST, FELLOWS AND SCHOLARS OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN") AND inv:"WHITEHEAD, Alexander Steven, Amberley" 第 1 页

1.

发明授权
METHOD FOR THE QUANTITATIVE MEASUREMENT OF HUMAN ACUTE PHASE SERUM AMYLOID A PROTEIN; RECOMBINANT PROTEIN; SPECIFIC ANTIBODY 失效
标题翻译： METHOD FOR人急性期血清淀粉样A蛋白的定量测定; 重组蛋白; 特异性抗体

公开(公告)号：EP0842434B1

公开(公告)日：2000-03-15

申请号：EP96926554.5

申请日：1996-07-19

申请人： THE PROVOST, FELLOWS AND SCHOLARS OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN

发明人： DOYLE, John Martin, 27 Kill Abbey , HOBSON, Hazel Audrey, Kilmagig House Avoca , WHITEHEAD, Alexander Steven, Amberley

IPC分类号： G01N33/68 , C07K14/47 , C12N15/12 , C07K16/18

CPC分类号： C07K14/4711 , G01N33/68 , Y10S435/961 , Y10S435/962 , Y10S435/975 , Y10S436/808

摘要： A method for the quantitative determination of human acute phase serum amyloid A protein (A-SAA) comprises contacting a sample of a biological fluid with antibody specific for A-SAA, the sample being reacted with an organic solvent prior to or simultaneous with antibody contact. The organic solvent is suitably a C1-C4 alcohol and the antibody can be used on the solid phase and as a component of the detection system of an enzyme linked immunosorbant assay. The method provides a sensitive and reliable measure of A-SAA and inflammatory status which can be used for the diagnosis and clinical management of both acute and chronic inflammatory conditions.