公开(公告)号：EP3744829A1

公开(公告)日：2020-12-02

申请号：EP19740768.7

申请日：2019-01-17

Applicant: THE RESEARCH FOUNDATION FOR MICROBIAL DISEASES OF OSAKA UNIVERSITY

Inventor： PIAO, Zhenyu ,  KOIZUMI, Yuka ,  MIYATAKE, Hiroshi

IPC: C12N1/20 ,  C12Q1/02

Abstract: An object of the present invention is to provide a technique capable of further increasing the absolute detection value and/or the ratio of the detection value to a reference in a pneumococcal antibody sample evaluation test, or a technique capable of evaluating pneumococcal antibody samples against a wider variety of pneumococcal strains.
The object is achieved by a medium for preparing a pneumococcal sample for use in a pneumococcal antibody sample evaluation test, the medium containing a solid medium.

公开(公告)号：EP3312287A1

公开(公告)日：2018-04-25

申请号：EP16811739.8

申请日：2016-06-17

Applicant: The Research Foundation for Microbial Diseases of Osaka University ,  Osaka University

Inventor： AKEDA, Yukihiro ,  MIYATAKE, Hiroshi ,  PIAO, Zhenyu ,  KOIZUMI, Yuka

IPC: C12Q1/02 ,  G01N33/15 ,  C07K16/12 ,  C12N1/20 ,  C12N5/078 ,  C12N5/0787

CPC classification number: C12Q1/18 ,  C07K16/12 ,  C12N1/20 ,  G01N2333/3156

Abstract: The present invention relates to a measurement method for complement-dependent bactericidal activity against Streptococcus pneumoniae, and provides a measurement method capable of measuring complement-dependent bactericidal activity against Streptococcus pneumoniae of any capsular serotype. Complement-dependent bactericidal activity against Streptococcus pneumoniae is measured using capsule-deficient Streptococcus pneumoniae, that is, non-encapsulated or substantially non-encapsulated, or transparent Streptococcus pneumoniae. The measurement of the complement-dependent bactericidal activity against Streptococcus pneumoniae of any capsular serotype is enabled.

Abstract translation: 本发明涉及针对肺炎链球菌的补体依赖性杀菌活性的测定方法，提供能够测定对任何荚膜血清型的肺炎链球菌的补体依赖性杀菌活性的测定方法。 使用缺乏胶囊的肺炎链球菌（即未包封的或基本上未包封的）或透明的肺炎链球菌来测量对肺炎链球菌的补体依赖性杀菌活性。 可以测量任何荚膜血清型对抗肺炎链球菌的补体依赖性杀菌活性。