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1.发明公开SYNTHETIC VACCINES AGAINST STREPTOCOCCUS PNEUMONIAE TYPE 1 有权合成器IMPFSTOFFE GEGEN STREPTOCOCCUS PNEUMONIAE VOM TYP 1
公开(公告)号：EP3019513A1
公开(公告)日：2016-05-18
申请号：EP14744787.4
申请日：2014-07-07
IPC分类号： C07H15/04 , C07K19/00 , A61K31/7028 , A61P31/04
CPC分类号： A61K39/092 , A61K47/646 , A61K2039/6037 , C07H15/04 , G01N33/56944 , G01N2333/3156 , G01N2469/20
摘要： The present invention relates to the total synthesis of saccharide structures contained in the capsular polysaccharide of Streptococcus pneumoniae type 1, to glycoconjugates containing said saccharide structures obtained by total synthesis and to use of such glycoconjugates and pharmaceutical compositions thereof in the immunization against diseases associated with bacteria containing said saccharide structures in their capsular polysaccharide, and more specifically associated with Streptococcus pneumoniae.
摘要翻译： 本发明涉及包含在1型肺炎链球菌的荚膜多糖中的糖结构的全合成，含有通过全合成获得的所述糖结构的糖缀合物，以及这些糖缀合物的使用及其药物组合物在与细菌相关的疾病的免疫中 在其荚膜多糖中含有所述糖结构，更具体地与肺炎链球菌有关。
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公开(公告)号：EP2235531B1
公开(公告)日：2015-01-14
申请号：EP09705818.4
申请日：2009-02-02
IPC分类号： G01N33/543 , G01N33/564 , G01N33/569
CPC分类号： G01N33/56944 , G01N33/53 , G01N33/569 , G01N2333/3156
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公开(公告)号：EP2162546A4
公开(公告)日：2011-04-13
申请号：EP08780704
申请日：2008-05-28
发明人： NAHM MOON H , PARK IN HO
CPC分类号： A61K39/092 , A61K39/385 , A61K2039/55588 , A61K2039/6031 , A61K2039/6081 , C07K16/1275 , C07K2317/24 , C12N1/20 , C12P19/04 , C12Q1/14 , C12Q1/689 , C12R1/46 , G01N33/56944 , G01N2333/3156
摘要： Disclosed is a new and emerging serotype of Streptococcus pneumoniae designated serotype 6D, and assays and monoclonal antibodies useful in identifying same. Also disclosed is a novel pneumococcal polysaccharide with the repeating unit ->2) glucose 1 (1->3) glucose 2 (1->3) rhamnose (1->4) ribitol (5->phosphate. This new serotype may be included in pneumococcal vaccines.
摘要翻译： 公开了一种新型和新出现的血清型6D的肺炎链球菌血清型，以及用于鉴定其的测定和单克隆抗体。 还公开了具有重复单元的新型肺炎球菌多糖 - > 2）葡萄糖1（1-> 3）葡萄糖2（1-> 3）鼠李糖（1-> 4）核糖醇（5->磷酸盐），这种新的血清型可以是 包括肺炎球菌疫苗。
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公开(公告)号：EP2235531A1
公开(公告)日：2010-10-06
申请号：EP09705818.4
申请日：2009-02-02
IPC分类号： G01N33/543 , G01N33/564 , G01N33/569
CPC分类号： G01N33/56944 , G01N33/53 , G01N33/569 , G01N2333/3156
摘要： Assays for detecting anti-streptococcal antibodies in biological samples using one or more streptococcal antigens are described herein. Various combinations of antigens may be used in the assays. For example, one or more of Ply, PhtD, PhtE, LytB and PcpA may be utilized. Additional streptococcal antigens may also be used. The assays may also be used in combination with assays that detect streptococcal nucleic acids.
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公开(公告)号：EP3075862B1
公开(公告)日：2017-11-15
申请号：EP16162980.3
申请日：2016-03-30
IPC分类号： C12Q1/04 , G01N33/558 , G01N33/569 , G01N33/68
CPC分类号： G01N33/6893 , A61B5/14507 , A61B5/6847 , A61B10/0045 , A61B2010/0006 , C12Q1/04 , G01N33/558 , G01N33/56911 , G01N33/56944 , G01N2333/212 , G01N2333/285 , G01N2333/3156 , G01N2800/14
摘要： Kits for sampling mucous from within a sinus and for assaying the sample to determine if the sample includes one or more types of bacteria indicating bacterial sinusitis from a single mucosal sample.
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公开(公告)号：EP3230297A1
公开(公告)日：2017-10-18
申请号：EP15724583.8
申请日：2015-05-15
IPC分类号： C07H15/04 , A61K31/7028 , A61P31/04
CPC分类号： A61K39/092 , A61K39/385 , A61K2039/575 , A61K2039/627 , C07H15/04 , C07H15/18 , G01N33/56944 , G01N2333/3156 , G01N2400/00 , G01N2469/20
摘要： The present invention relates to synthetic saccharides of general formula (I) that are related to Streptococcus pneumoniae serotype 4 capsular polysaccharide and conjugates thereof. Said conjugate and a pharmaceutical composition containing said conjugate are useful for prevention and/or treatment of diseases associated with Streptococcus pneumoniae, and more specifically of diseases associated with Streptococcus pneumoniae serotype 4. Furthermore, the synthetic saccharides of general formula (I) are useful as marker in immunological assays for detection of antibodies against Streptococcus pneumoniae bacteria.
摘要翻译： 本发明涉及通式（I）的合成糖类，其涉及肺炎链球菌血清型4荚膜多糖及其缀合物。 所述缀合物和包含所述缀合物的药物组合物可用于治疗与肺炎链球菌，并且更具体地与肺炎链球菌血清型4。此外相关的疾病相关的疾病的预防和/或治疗是有用的，通式（I）的合成糖是有用 用于检测针对肺炎链球菌细菌的抗体的免疫学测定中的标记。
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7.发明授权
公开(公告)号：EP2788496B1
公开(公告)日：2017-09-27
申请号：EP12794719.0
申请日：2012-12-03
发明人： RÜTHER, Horst , AMANN, Anton
IPC分类号： C12Q1/04 , C12Q1/14 , G01N33/497
CPC分类号： C12Q1/14 , C12Q1/04 , G01N33/497 , G01N2033/4977 , G01N2333/21 , G01N2333/285 , G01N2333/31 , G01N2333/315 , G01N2333/3156 , G01N2800/26
摘要： The present invention relates to a method of diagnosing an existing or developing acute pneumonia induced by a microorganism by detecting one or more volatile organic compound(s) in a subject's sample and the use of one or more volatile organic compound(s) for the detection of Staphylococcus aureus, Pseudomonas aeruginosa, Streptococcus pneumoniae or Haemophilus influenza and optionally opportunistic pathogen Candida albicans.
摘要翻译： 本发明涉及通过检测受试者样品中的一种或多种挥发性有机化合物和使用一种或多种挥发性有机化合物进行检测来诊断由微生物诱导的现有或发展的急性肺炎的方法 金黄色葡萄球菌，铜绿假单胞菌，肺炎链球菌或流感嗜血杆菌和任选机会性病原体白色念珠菌。
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公开(公告)号：EP2261666B1
公开(公告)日：2015-12-02
申请号：EP09726757.9
申请日：2009-03-31
发明人： AKAMATSU, Suguru , SAIJO, Yoko
IPC分类号： G01N33/569 , C07K16/12 , C12N15/02
CPC分类号： C07K16/1275 , G01N33/56944 , G01N2333/3156 , G01N2469/10
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公开(公告)号：EP0861890A1
公开(公告)日：1998-09-02
申请号：EP98301482.0
申请日：1998-02-27
IPC分类号： C12N15/11 , C12N15/70 , C07K16/12 , C07K14/315 , G01N33/50
CPC分类号： C07K14/3156 , A61K39/00 , G01N33/56944 , G01N33/68 , G01N2333/3156
摘要： The invention provides licC polypeptides and polynucleotides encoding licC polypeptides and methods for producing such polypeptides by recombinant techniques. Also provided are methods for utilizing licC polypeptides to screen for antibacterial compounds.
摘要翻译： 本发明提供了licC多肽和编码licC多肽的多核苷酸以及通过重组技术产生此类多肽的方法。 还提供了利用licC多肽筛选抗菌化合物的方法。
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10.发明公开CARDIOTONIC STEROID ANTAGONISTS AND RELATED METHODS 有权HERZSTÄRKENDESTEROIDANTAGONISTEN UNDZUGEHÖRIGEVERFAHREN
公开(公告)号：EP3126378A4
公开(公告)日：2017-09-06
申请号：EP15779886
申请日：2015-04-02
发明人： XIE ZIJIAN , BANERJEE MOUMITA
IPC分类号： C07K14/47 , C07K7/08 , G01N33/573
CPC分类号： C12N9/14 , A61K38/00 , A61K38/46 , A61K45/06 , C07K7/08 , C07K2319/00 , C07K2319/01 , C12Q1/485 , C12Q1/50 , C12Y306/03009 , G01N33/5044 , G01N33/573 , G01N2333/3153 , G01N2333/3156 , G01N2333/91 , G01N2333/9723
摘要： Non-naturally occurring peptides are provided that act as a Src SH2 domain antagonist of cardiotonic steroids. Pharmaceutical compositions comprising the peptides are also provided along with vectors encoding the peptides. Methods of treating a Src-associated disease and reducing Src activity in a cell are further provided and include administering or contacting a cell with an effective amount of the peptide.
摘要翻译： 提供了非天然存在的肽，其充当强心类固醇的Src SH2结构域拮抗剂。 还提供了包含该肽的药物组合物以及编码该肽的载体。 还提供了治疗细胞中Src相关疾病和降低Src活性的方法，并且包括给细胞施用或接触有效量的肽。
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