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1.发明公开CHARACTERIZATION OF A CHROMOSOME 11Q23 TRANSLOCATION BREAKPOINT ASSOCIATED WITH ACUTE LEUKEMIAS 失效染色体11q23的易位断裂与表征急性白血病相关联。
公开(公告)号：EP0668765A1
公开(公告)日：1995-08-30
申请号：EP93922371.0
申请日：1993-09-24
CPC分类号： C12Q1/6883 , A61K38/00 , C07K14/4702 , C12Q2600/156
摘要： In accordance with the present invention, there is provided an isolated peptide having the characteristics of human trithorax protein (as well as DNA encoding same, antisense DNA derived therefrom and antagonists therefor). The invention peptide is characterized by having a DNA binding domain comprising multiple zinc fingers and at least 40 % amino acid identity with respect to the DNA binding domain of Drosophila trithorax protein and at least 70 % conserved sequence with respect to the DNA binding domain of Drosophila trithorax protein, and wherein said peptide is encoded by a gene located at chromosome 11 of the human genome at q23. Also provided are methods for the treatment of subject(s) suffering from immunodeficiency, developmental abnormality, inherited disease, or cancer by administering to said subject a therapeutically effective amount of one of the above-described agents (i.e., peptide, antagonist therefor, DNA encoding said peptide or antisense DNA derived therefrom). Also provided is a method for the diagnosis, in a subject, of immunodeficiency, developmental abnormality, inherited disease, or cancer associated with disruption of chromosome 11 at q23.
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