公开(公告)号：EP0577771A1

公开(公告)日：1994-01-12

申请号：EP92911001.0

申请日：1992-03-13

申请人： THE SALK INSTITUTE FOR BIOLOGICAL STUDIES

发明人： EVANS, Glen, A. ,  SELLERI, Licia ,  HERMANSON, Gary, G.

IPC分类号： C07H21 ,  C12Q1

CPC分类号： C12Q1/6841 ,  C12Q1/6813 ,  C12Q1/6827 ,  C12Q1/6886 ,  C12Q2600/112

摘要： Procédés permettant de déterminer l'existence, et éventuellement l'emplacement, d'aberration(s) chromosomique(s) dans le génome d'un organisme. De l'ADN chromosomique intact est hybridé avec un ou plusieurs clones produits à partir d'ADN chromosomique dérivé d'un organisme de la même espèce qu'un organisme à tester. Grâce à la détermination de l'existence d'une aberration chromosomique, on peut prédire la susceptibilité d'un individu de développer certaines conditions pathologiques, et/ou l'on peut cerner un état pathologique donné avec une plus grande certitude.

公开(公告)号：EP0668765A1

公开(公告)日：1995-08-30

申请号：EP93922371.0

申请日：1993-09-24

申请人： THE SALK INSTITUTE FOR BIOLOGICAL STUDIES

发明人： EVANS, Glen, A. ,  DJABAKI, Malek ,  SELLERI, Licia ,  PARRY, Pauline

IPC分类号： C07K14 ,  C12Q1 ,  A61K38

CPC分类号： C12Q1/6883 ,  A61K38/00 ,  C07K14/4702 ,  C12Q2600/156

摘要： In accordance with the present invention, there is provided an isolated peptide having the characteristics of human trithorax protein (as well as DNA encoding same, antisense DNA derived therefrom and antagonists therefor). The invention peptide is characterized by having a DNA binding domain comprising multiple zinc fingers and at least 40 % amino acid identity with respect to the DNA binding domain of Drosophila trithorax protein and at least 70 % conserved sequence with respect to the DNA binding domain of Drosophila trithorax protein, and wherein said peptide is encoded by a gene located at chromosome 11 of the human genome at q23. Also provided are methods for the treatment of subject(s) suffering from immunodeficiency, developmental abnormality, inherited disease, or cancer by administering to said subject a therapeutically effective amount of one of the above-described agents (i.e., peptide, antagonist therefor, DNA encoding said peptide or antisense DNA derived therefrom). Also provided is a method for the diagnosis, in a subject, of immunodeficiency, developmental abnormality, inherited disease, or cancer associated with disruption of chromosome 11 at q23.

公开(公告)号：EP0666864B1

公开(公告)日：1999-11-24

申请号：EP92921979.8

申请日：1992-10-07

申请人： THE SALK INSTITUTE FOR BIOLOGICAL STUDIES

发明人： EVANS, Glen, A. ,  SELLERI, Licia 201 Fourth Street ,  EUBANKS, James, H.

IPC分类号： C12Q1/68

CPC分类号： C12Q1/6827 ,  C12Q1/6841 ,  C12Q1/6858 ,  C12Q1/6876 ,  C12Q2600/156

公开(公告)号：EP0666864A1

公开(公告)日：1995-08-16

申请号：EP92921979.0

申请日：1992-10-07

申请人： THE SALK INSTITUTE FOR BIOLOGICAL STUDIES

发明人： EVANS, Glen, A. ,  SELLERI, Licia 201 Fourth Street ,  EUBANKS, James, H.

IPC分类号： G01N33 ,  C07H21 ,  C12Q1

CPC分类号： C12Q1/6827 ,  C12Q1/6841 ,  C12Q1/6858 ,  C12Q1/6876 ,  C12Q2600/156

摘要： Nucleotide sequence defining a polymorphic locus useful for identification of an individual. Also disclosed are oligonucleotide primers useful in amplification of the locus and methods for detecting the amplified locus.