公开(公告)号：EP1639116A2

公开(公告)日：2006-03-29

申请号：EP04755025.6

申请日：2004-06-10

申请人： THE SCRIPPS RESEARCH INSTITUTE

发明人： NEMEROW, Glen, R. ,  WU, Eugene ,  STEWART, Phoebe

IPC分类号： C12N15/861 ,  C07K14/075 ,  C12N15/34 ,  A61K48/00

CPC分类号： C07K14/005 ,  C07K2319/01 ,  C12N15/86 ,  C12N2710/10322 ,  C12N2710/10343 ,  C12N2710/10345 ,  C12N2810/6018

摘要： Recombinant detargeted and retargeted adenovirus viral particles and vectors are provided. In particular, modified fibers from adenoviruses that bind to coxsackie-adenovirus receptor (CAR) in vivo that contain modifications in the fiber shaft are provided. Adenovirus (Ad) particles that express such fibers exhibit reduced binding to CAR. Hence detargeted Ad particles are provides; also provided are retargeted particles.