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公开(公告)号：EP1404860B8
公开(公告)日：2013-12-25
申请号：EP02741778.1
申请日：2002-05-30
申请人： THE SCRIPPS RESEARCH INSTITUTE , The Board of Trustees of the Leland Stanford Junior University
发明人： CHERESH, David, A. , HOOD, John , BEDNARSKI, Mark
CPC分类号： B82Y5/00 , A61K47/6911 , A61K48/00
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公开(公告)号：EP1404860B1
公开(公告)日：2013-11-20
申请号：EP02741778.1
申请日：2002-05-30
发明人： CHERESH, David, A. , HOOD, John , BEDNARSKI, Mark
CPC分类号： B82Y5/00 , A61K47/6911 , A61K48/00
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公开(公告)号：EP1404860A2
公开(公告)日：2004-04-07
申请号：EP02741778.1
申请日：2002-05-30
申请人： The Scripps Research Institute , The Board of Trustees of The Leland S. Stanford Junior University
发明人： CHERESH, David, A. , HOOD, John , BEDNARSKI, Mark
IPC分类号： C12Q1/00
CPC分类号： B82Y5/00 , A61K47/6911 , A61K48/00
摘要： αvβ3 Integrin receptor targeting liposomes comprise a cationic amphiphile such as a cationic lipid, a neutral lipid, and a targeting lipid. The targeting lipid includes a non-peptidic αvβ3 integrin antagonist.
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4.发明公开METHODS AND COMPOSITIONS USEFUL FOR MODULATION OF ANGIOGENESIS USING PROTEIN KINASE RAF AND RAS 审中-公开方法和连接基于蛋白激酶Raf和RAS调制血管生成
公开(公告)号：EP1210099A1
公开(公告)日：2002-06-05
申请号：EP00955423.9
申请日：2000-08-11
发明人： HOOD, John , ELICEIRI, Brian , CHERESH, David, A.
摘要： The present invention describes methods for modulating angiogenesis in tissues using Raf and/or Ras protein, modified Raf or Ras protein, and nucleic acids encoding for such. Particularly the invention describes methods for inhibiting angiogenesis using an inactive Raf and/or Ras protein, or nucleic acids encoding therefor, or for potentiating angiogenesis using an active Raf and/or Ras protein, or nucleic acids encoding therefor. The invention also describes the use of gene delivery systems for providing nucleic acids encoding for the Raf or Ras protein, or modified forms thereof.
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