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公开(公告)号：EP1087941A2
公开(公告)日：2001-04-04
申请号：EP99930428.0
申请日：1999-06-18
发明人： TURPIN, Jim, A. , SONG, Yongsheng , INMAN, John, K. , HUANG, Mingjun , WALLQVIST, Anders , MAYNARD, Andrew , COVELL, David, G. , RICE, William, G. , APPELLA, Ettore
IPC分类号： C07C319/00
CPC分类号： C07D213/76 , C07C327/32 , C07D213/61 , C07D231/42 , C07D237/20 , C07D237/22 , C07D239/42 , C07D239/47 , C07D239/545 , C07D241/44 , C07D261/14 , C07D261/16 , C07D263/48 , C07D263/50 , C07D275/04 , C07D275/06 , C07D277/52 , C07D285/135 , C07D333/38 , C07D417/12
摘要： This invention pertains to the discovery of a novel family of thiolesters and uses thereof. Also provided for are viricidal compounds and pharmaceutical formulations comprising these novel thiolesters. The invention also provides thiolester-inactivated viruses and thiolester-complexed viral proteins.
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公开(公告)号：EP1087941B9
公开(公告)日：2007-11-07
申请号：EP99930428.0
申请日：1999-06-18
发明人： TURPIN, Jim, A. , SONG, Yongsheng , INMAN, John, K. , HUANG, Mingjun , WALLQVIST, Anders , MAYNARD, Andrew , COVELL, David, G. , RICE, William, G. , APPELLA, Ettore
IPC分类号： C07C319/00
CPC分类号： C07D213/76 , C07C327/32 , C07D213/61 , C07D231/42 , C07D237/20 , C07D237/22 , C07D239/42 , C07D239/47 , C07D239/545 , C07D241/44 , C07D261/14 , C07D261/16 , C07D263/48 , C07D263/50 , C07D275/04 , C07D275/06 , C07D277/52 , C07D285/135 , C07D333/38 , C07D417/12
摘要： This invention pertains to the discovery of a novel family of thiolesters and uses thereof. Also provided for are viricidal compounds and pharmaceutical formulations comprising these novel thiolesters. The invention also provides thiolester-inactivated viruses and thiolester-complexed viral proteins.
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公开(公告)号：EP4380613A1
公开(公告)日：2024-06-12
申请号：EP22758403.4
申请日：2022-08-02
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公开(公告)号：EP1087941B1
公开(公告)日：2006-08-16
申请号：EP99930428.0
申请日：1999-06-18
发明人： TURPIN, Jim, A. , SONG, Yongsheng , INMAN, John, K. , HUANG, Mingjun , WALLQVIST, Anders , MAYNARD, Andrew , COVELL, David, G. , RICE, William, G. , APPELLA, Ettore
IPC分类号： C07C319/00
CPC分类号： C07D213/76 , C07C327/32 , C07D213/61 , C07D231/42 , C07D237/20 , C07D237/22 , C07D239/42 , C07D239/47 , C07D239/545 , C07D241/44 , C07D261/14 , C07D261/16 , C07D263/48 , C07D263/50 , C07D275/04 , C07D275/06 , C07D277/52 , C07D285/135 , C07D333/38 , C07D417/12
摘要： This invention pertains to the discovery of a novel family of thiolesters and uses thereof. Also provided for are viricidal compounds and pharmaceutical formulations comprising these novel thiolesters. The invention also provides thiolester-inactivated viruses and thiolester-complexed viral proteins.
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5.发明公开COMPOUNDS FOR INHIBITING WIP1, PRODRUGS AND COMPOSITIONS THEREOF, AND RELATED METHODS 审中-公开化合物用于抑制WIP1，前药和它们的组合物及相关方法
公开(公告)号：EP2188296A1
公开(公告)日：2010-05-26
申请号：EP08798994.3
申请日：2008-08-29
发明人： APPELLA, Ettore , APPELLA, Daniel , DURELL, Stewart R. , BANG, Jeong , YAMAGUCHI, Hiroshi , XU, Qun
IPC分类号： C07F9/572 , A61K31/6615 , A61K31/675 , A61P35/00
CPC分类号： C07F9/5722 , A61K31/6615 , A61K31/675
摘要： The invention provides compounds useful in inhibiting the activity of a Wip1 protein in a cell as well as prodrugs thereof, related methods of use and compositions which include the aforesaid compounds and prodrugs thereof. The compounds comprise a ring structure having at least five functional groups bonded thereto, wherein each functional group is bonded to a different ring atom, and wherein the at least five functional groups comprise: (a) first (R1) and second (R3) moieties each comprising a phosphate group wherein these first and second moieties are separated by at least one ring atom; (b) first (R2) and second (R4) hydrophobic groups, wherein the first and second hydrophobic groups are separated by at least one ring atom, and wherein the first hydrophobic group is bonded to a ring atom located between the ring atoms to which the first (R1) and second (R2) moieties are bonded; and an amide or carboxylic acid (R5).
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