公开(公告)号：EP3519409B1

公开(公告)日：2024-09-18

申请号：EP17784466.9

申请日：2017-09-26

IPC分类号： C07D417/04 ,  C07D417/14 ,  C07D471/04 ,  C07D487/04 ,  A61K31/428 ,  A61P31/18

CPC分类号： A61P31/18 ,  A61K31/428 ,  A61K31/439 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/496 ,  A61K31/4985 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/5383 ,  A61K31/55 ,  A61K31/551 ,  C07D417/04 ,  C07D417/14 ,  C07D471/04 ,  C07D471/08 ,  C07D487/04 ,  C07D487/08 ,  C07D487/10 ,  C07D491/107 ,  C07D498/04

公开(公告)号：EP4426315A1

公开(公告)日：2024-09-11

申请号：EP22813903.6

申请日：2022-11-01

申请人： Immunic AG

发明人： GEGE, Christian ,  KOHLHOF, Hella ,  MÜHLER, Andreas ,  VITT, Daniel

IPC分类号： A61K31/7068 ,  A61P31/12 ,  A61P31/14 ,  A61P31/16 ,  A61P31/18

CPC分类号： A61P31/12 ,  A61P31/14 ,  A61P31/18 ,  A61P31/16 ,  A61K31/7068 ,  Y02A50/30

公开(公告)号：EP4422747A1

公开(公告)日：2024-09-04

申请号：EP22809395.1

申请日：2022-10-25

申请人： Perha Pharmaceuticals

发明人： DEAU, Emmanuel ,  GEORGE, Pascal ,  MEIJER, Laurent ,  MIEGE, Frédéric ,  ARCHAMBAUD, Sylvie

IPC分类号： A61P3/00 ,  A61P3/10 ,  A61P19/02 ,  A61P25/00 ,  A61P25/16 ,  A61P25/28 ,  A61P31/00 ,  A61P31/12 ,  A61P31/16 ,  A61P31/18 ,  A61P31/22 ,  A61P33/00 ,  A61P33/06 ,  A61P35/00 ,  C07D401/06 ,  C07D401/14 ,  C07D403/06 ,  C07D403/14 ,  C07D405/14 ,  C07D417/14 ,  C07D471/04

CPC分类号： A61P3/00 ,  C07D417/14 ,  C07D403/06 ,  C07D403/14 ,  C07D405/14 ,  C07D401/06 ,  C07D401/14 ,  C07D471/04 ,  A61P3/10 ,  A61P19/02 ,  A61P25/00 ,  A61P25/16 ,  A61P25/28 ,  A61P31/00 ,  A61P31/12 ,  A61P31/16 ,  A61P31/18 ,  A61P31/22 ,  A61P33/00 ,  A61P33/06 ,  A61P35/00

公开(公告)号：EP4417217A2

公开(公告)日：2024-08-21

申请号：EP24178565.8

申请日：2017-04-20

申请人： 4TEEN4 Pharmaceuticals GmbH

发明人： BERGMANN, Andreas

IPC分类号： A61K39/395

CPC分类号： G01N33/574 ,  G01N33/6893 ,  G01N2333/94820130101 ,  G01N2800/2620130101 ,  G01N2800/32520130101 ,  G01N2800/34720130101 ,  C07K16/40 ,  A61K2039/50520130101 ,  A61K2039/54520130101 ,  C07K2317/7320130101 ,  C07K2317/7620130101 ,  C07K2317/9020130101 ,  A61P1/16 ,  A61P13/12 ,  A61P17/02 ,  A61P25/00 ,  A61P31/00 ,  A61P31/04 ,  A61P31/12 ,  A61P31/18 ,  A61P33/00 ,  A61P33/06 ,  A61P35/00 ,  A61P9/00 ,  A61P9/02 ,  A61P9/04 ,  A61P9/10 ,  Y02A50/30

摘要： The present invention is directed to methods for determining active DPP3 in a bodily fluid sample, an assay or kit for determining active DPP3 in a bodily fluid sample, a method for diagnosing a disease or condition in a subject accompanied by or related to necrotic processes and methods of treating or preventing said disease.

公开(公告)号：EP4403579A2

公开(公告)日：2024-07-24

申请号：EP24167554.5

申请日：2012-05-02

申请人： Millennium Pharmaceuticals, Inc.

发明人： DILUZIO, Willow ,  NGUYEN, Phuong M. ,  VARGA, Csanad M. ,  PALANIAPPAN, Vaithianathan ,  BROWN, Jason ,  FOX, Irving H. ,  SCHOLZ, Catherine ,  JENKINS, Erica Helen ,  ROSARIO, Maria

IPC分类号： C07K16/28

CPC分类号： A61K9/0019 ,  A61K47/12 ,  A61K47/14 ,  A61K47/183 ,  A61K47/26 ,  A61K39/39591 ,  A61K2039/50520130101 ,  A61K2039/5420130101 ,  A61K2039/54520130101 ,  C07K2317/2420130101 ,  C07K16/2839 ,  A61P1/00 ,  A61P1/04 ,  A61P1/16 ,  A61P1/18 ,  A61P29/00 ,  A61P31/18 ,  A61P37/06 ,  A61P43/00 ,  A61P3/10

摘要： Antibody formulations are described comprising a mixture of an anti-α4β7 antibody, an antioxidant or chelator, and at least one free amino acid. The disclosed formulations may have improved stability, reduced aggregate formation, or both. The present invention further provides a safe dosing regimen of these antibody formulations that is easy to follow, and which results in a therapeutically effective amount of the anti-α4β7 antibody in vivo.

公开(公告)号：EP4403221A2

公开(公告)日：2024-07-24

申请号：EP24169258.1

申请日：2008-02-22

申请人： Gilead Sciences, Inc.

发明人： DESAI, Manoj, C. ,  HONG, Allen, Y. ,  HUI, Hon, C. ,  LIU, Hongtao ,  VIVIAN, Randall, W. ,  XU, Lianhong

IPC分类号： A61P31/00

CPC分类号： A61K31/426 ,  A61K31/427 ,  A61K31/496 ,  A61K31/5377 ,  A61K45/06 ,  A61P31/00 ,  A61P31/12 ,  A61P31/14 ,  A61P31/18 ,  A61P43/00

摘要： The present application provides for a compound of Formula IV,

or a pharmaceutically acceptable salt, solvate, and/or ester thereof, compositions containing such compounds, therapeutic methods that include the administration of such compounds, and therapeutic methods and include the administration of such compounds with at least one additional therapeutic agent.

公开(公告)号：EP4400510A2

公开(公告)日：2024-07-17

申请号：EP24158688.2

申请日：2007-07-30

申请人： The Trustees of the University of Pennsylvania

发明人： Weiner, David B. ,  Yan, Jian

IPC分类号： C07K14/00

CPC分类号： C12N2740/1612220130101 ,  C12N2740/1613420130101 ,  C12N2740/1622220130101 ,  C12N2740/1623420130101 ,  C12N2740/1632220130101 ,  C12N2740/1633420130101 ,  A61K39/12 ,  A61K2039/52320130101 ,  A61K2039/5320130101 ,  C12N2710/2003420130101 ,  C12N2760/1613420130101 ,  C12N2770/2423420130101 ,  A61K38/00 ,  A61K2039/5420130101 ,  A61K2039/5553820130101 ,  A61K2039/58520130101 ,  C07K14/005 ,  A61P15/00 ,  A61P31/12 ,  A61P31/14 ,  A61P31/16 ,  A61P31/18 ,  A61P31/20 ,  A61P35/00 ,  A61P37/04 ,  A61K39/001157 ,  A61K39/00 ,  A61K39/4611 ,  A61K39/0011 ,  A61K39/464838

摘要： Improved anti-HIV immunogens and nucleic acid molecules that encode them are disclosed. Immunogens disclosed include those having consensus sequences for HIV Subtype A Envelope protein, those having consensus sequences for HIV Subtype B Envelope protein, those having consensus sequences for HIV Subtype C Envelope protein, those having consensus sequences for HIV Subtype D Envelope protein, those having consensus sequences for HIV Subtype B consensus Nef-Rev protein, and those having consensus sequences for HIV Gag protein subtypes A, B, C and D. Improved anti-HPV immunogens and nucleic acid molecules that encode them; improved anti-HCV immunogens and nucleic acid molecules that encode them; improved hTERT immunogens and nucleic acid molecules that encode them; and improved anti-Influenza immunogens and nucleic acid molecules that encode them are disclosed. Pharmaceutical composition, recombinant vaccines comprising and live attenuated pathogens are disclosed as well methods of inducing an immune response in an individual against HIV, HPV, HCV, hTERT and Influenza are disclosed.

公开(公告)号：EP4397675A2

公开(公告)日：2024-07-10

申请号：EP24163980.6

申请日：2013-09-12

申请人： Bristol-Myers Squibb Company

发明人： CLOAD, Sharon ,  ENGLE, Linda ,  LIPOVSEK, Dasa ,  MADIREDDI, Malavi ,  RAKESTRAW, Ginger, Chao ,  SWAIN, Joanna F. ,  ZHAO, Wenjun ,  WEI, Hui ,  YAMNIUK, Aaron, P. ,  KOZHICH, Alexander, T. ,  RAMAMURTHY, Vidhyashankar ,  CORBETT, Martin, J. ,  KRYSTEK, Stanley, Richard, Jr.

IPC分类号： C07K14/435

CPC分类号： A61K47/60 ,  C07K14/78 ,  A61K38/39 ,  A61K45/06 ,  A61K38/17 ,  A61K38/1709 ,  A61K38/00 ,  A61P11/00 ,  A61P13/12 ,  A61P19/00 ,  A61P19/02 ,  A61P19/10 ,  A61P21/00 ,  A61P21/02 ,  A61P29/00 ,  A61P3/00 ,  A61P3/04 ,  A61P31/18 ,  A61P35/00 ,  A61P3/06 ,  A61P5/50 ,  A61P7/12 ,  A61P9/10 ,  A61P3/10

摘要： The present invention relates to fibronectin-based scaffold domain proteins that bind to myostatin. The invention also relates to the use of these proteins in therapeutic applications to treat muscular dystrophy, cachexia, sarcopenia, osteoarthritis, osteoporosis, diabetes, obesity, COPD, chronic kidney disease, heart failure, myocardial infarction, and fibrosis. The invention further relates to cells comprising such proteins, polynucleotides encoding such proteins or fragments thereof, and to vectors comprising the polynucleotides encoding the proteins.

公开(公告)号：EP4387629A1

公开(公告)日：2024-06-26

申请号：EP22765558.6

申请日：2022-08-18

申请人： Katholieke Universiteit Leuven KU Leuven Research & Development

发明人： HERDEWIJN, Piet ,  ZHENG, Zihua ,  GROAZ, Elisabetta

IPC分类号： A61K31/7064 ,  A61P31/12 ,  A61P31/14 ,  A61P31/16 ,  A61P31/18 ,  C07D239/00

CPC分类号： A61K31/7064 ,  A61P31/12 ,  A61P31/14 ,  A61P31/16 ,  A61P31/18 ,  C07H19/067 ,  Y02A50/30

公开(公告)号：EP3416685B1

公开(公告)日：2024-06-26

申请号：EP17708398.7

申请日：2017-02-17

IPC分类号： A61K39/395 ,  C07K16/12 ,  C07K16/28 ,  A61K39/00 ,  A61P1/16 ,  A61P11/00 ,  A61P11/14 ,  A61P31/00 ,  A61P29/00 ,  A61P35/00 ,  A61P43/00 ,  A61P31/06 ,  A61P31/04 ,  A61P31/08 ,  A61P31/14 ,  A61P31/18 ,  A61P31/16 ,  A61P31/20 ,  A61P31/22 ,  A61P17/00 ,  A61P37/04

CPC分类号： A61K39/395 ,  C07K16/1225 ,  C07K16/28 ,  A61K2039/5420130101 ,  A61K2039/5520130101 ,  A61K2039/5550520130101 ,  A61K2039/62220130101 ,  C07K2317/7020130101 ,  A61K2039/50520130101 ,  C07K2317/7620130101 ,  C07K2317/56520130101 ,  A61K2039/5720130101 ,  A61P1/16 ,  A61P11/00 ,  A61P11/14 ,  A61P17/00 ,  A61P29/00 ,  A61P31/00 ,  A61P31/04 ,  A61P31/06 ,  A61P31/08 ,  A61P31/14 ,  A61P31/16 ,  A61P31/18 ,  A61P31/20 ,  A61P31/22 ,  A61P33/06 ,  A61P35/00 ,  A61P37/04 ,  A61P43/00 ,  Y02A50/30 ,  A61K39/099 ,  A61K39/39 ,  A61K2039/5551620130101 ,  A61K39/08 ,  A61K2039/7020130101 ,  A61K2039/54520130101 ,  A61K39/00 ,  A61K39/001119