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公开(公告)号：EP1027033B1
公开(公告)日：2009-07-22
申请号：EP98921310.3
申请日：1998-05-14
发明人： SEMPLE, Sean, C. , KLIMUK, Sandra, K. , HARASYM, Troy , HOPE, Michael, J. , ANSELL, Steven, M. , CULLIS, Pieter , SCHERRER, Peter , DEBEYER, Dan
CPC分类号： A61K9/1277 , A61K9/1272 , Y10T428/2984
摘要： Methods for the preparation of a lipid-nucleic acid composition are provided. According to the methods, a mixture of lipids containing a protonatable or deprotonatable lipid, for example an amino lipid and a lipid such as a PEG- or polyamide oligomer-modified lipid is combined with a buffered aqueous solution of a charged therapeutic agent, for example polyanionic nucleic acids, to produce particles in which the therapeutic agent is encapsulated in a lipid vesicle. Surface charges on the lipid particles are at least partially neutralized to provide surface-neutralized lipid-encapsulated compositions of the therapeutic agents. The method permits the preparation of compositions with high ratios of therapeutic agent to lipid and with encapsulation efficiencies in excess of 50 %.
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公开(公告)号：EP0906421A1
公开(公告)日：1999-04-07
申请号：EP97921565.0
申请日：1997-05-22
IPC分类号： C12N15 , A61K9 , A61K31 , A61K47 , A61K48 , A61P1 , A61P5 , A61P9 , A61P17 , A61P19 , A61P25 , A61P27 , A61P31 , A61P37 , A61P43 , A61K38
CPC分类号： C12N15/1138 , A61K9/127 , A61K38/00 , C12N2310/3125 , C12N2310/315
摘要： Pharmaceutical compositions for the treatment of pathologic conditions associated with the overexpression of ICAM-1 in a host. These pharmaceutical compositions comprise an effective amount of an ICAM-1 antisense molecule encapsulated in a lipid mixture which is typically a liposome or lipid particle. The lipid mixture will typically comprise at least two members selected from the group consisting of phospholipids, sterols and cationic lipids.
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