公开(公告)号：EP1200117A2

公开(公告)日：2002-05-02

申请号：EP00943499.4

申请日：2000-06-23

申请人： THE UNIVERSITY OF BRITISH COLUMBIA ,  Amsterdam Molecular Therapeutics B.V. (AMT) ,  Academic Hospital at the University of Amsterdam

发明人： HAYDEN, Michael, R. ,  KASTELEIN, John, J., P.

IPC分类号： A61K38/46 ,  A61K48/00 ,  C12N15/63 ,  A61P9/10

CPC分类号： C12N9/20 ,  A61K38/00 ,  A61K48/00 ,  C12Y301/01034

摘要： The invention provides for the use of a therapeutic derived from a truncated lipoprotein lipase protein (LPL S447X), including nucleic acids encoding such proteins, for the treatment of conditions including LPL responsive conditions, such as cardiovascular disease, hypertension, LPL deficiency, high triglyceride levels, low HDL-cholesterol levels or atherosclerosis.

公开(公告)号：EP1200117B1

公开(公告)日：2008-08-13

申请号：EP00943499.4

申请日：2000-06-23

申请人： THE UNIVERSITY OF BRITISH COLUMBIA ,  Amsterdam Molecular Therapeutics B.V.

发明人： HAYDEN, Michael, R. ,  KASTELEIN, John, J., P. ,  EXCOFFON, Katherine Julia Diane Ashbourne

IPC分类号： A61K38/46 ,  A61K48/00 ,  C12N15/63 ,  A61P9/10 ,  C12N9/20

CPC分类号： C12N9/20 ,  A61K38/00 ,  A61K48/00 ,  C12Y301/01034