公开(公告)号：EP1328254A2

公开(公告)日：2003-07-23

申请号：EP01983342.5

申请日：2001-10-25

申请人： The University of British Columbia ,  Inex Pharmaceuticals Corp.

发明人： CULLIS, Pieter, R. ,  MACLACHLAN, Ian ,  FENSKE, David, B.

IPC分类号： A61K9/127

CPC分类号： A61K9/1272

摘要： The present invention provides lipid-based systemic delivery vehicles and method for selectively targeting an active agent to a specific tissue site. The methods include designing a lipid-based systemic delivery vehicle having a plurality of constitutent parts, and thereafter varying the amounts of each of the plurality of constituent parts to impart tissue selectivity. After tissue selectivity is imparted it is possible to selectively target an active agent to a specific tissue site.

公开(公告)号：EP1328254B1

公开(公告)日：2007-02-21

申请号：EP01983342.5

申请日：2001-10-25

申请人： THE UNIVERSITY OF BRITISH COLUMBIA ,  INEX Pharmaceuticals Corp.

发明人： CULLIS, Pieter, R. ,  MACLACHLAN, Ian ,  FENSKE, David, B.

IPC分类号： A61K9/127

CPC分类号： A61K9/1272

摘要： The present invention provides lipid-based systemic delivery vehicles and method for selectively targeting an active agent to a specific tissue site. The methods include designing a lipid-based systemic delivery vehicle having a plurality of constitutent parts, and thereafter varying the amounts of each of the plurality of constituent parts to impart tissue selectivity. After tissue selectivity is imparted it is possible to selectively target an active agent to a specific tissue site.

公开(公告)号：EP1082419A2

公开(公告)日：2001-03-14

申请号：EP99917711.6

申请日：1999-04-22

申请人： Inex Pharmaceuticals Corp.

发明人： JOSHI, Phalgun, B. ,  MORTIMER, Ian, C. ,  TAM, Patrick, M., S. ,  MACLACHLAN, Ian ,  GRAHAM, Roger, W.

IPC分类号： C12N15/00

CPC分类号： A61K48/00 ,  A61K41/0038 ,  C12N15/87

摘要： The present invention relates to methods for increasing the efficiency of transformation of cycling cells, the methods comprising synchronizing cells at a first stage of the cell cycle, and transforming the cells at a second stage of the cell cycle within about one cell cycle of the first stage with a genetically engineered nucleic acid that encodes a desired gene product. The invention further relates to cancer therapy and, in particular, to methods of efficiently transforming cancer cells with nucleic acids that encode gene products that inhibit the growth of cancer cells.

公开(公告)号：EP1053023A2

公开(公告)日：2000-11-22

申请号：EP99903557.9

申请日：1999-02-03

申请人： Inex Pharmaceuticals Corp.

发明人： MACLACHLAN, Ian ,  GRAHAM, Roger

IPC分类号： A61K48/00

CPC分类号： A61K48/00 ,  A61K38/208 ,  A61K38/45 ,  A61K38/51 ,  C12N15/88

摘要： The present invention relates to methods and compositions for treating a neoplasia in a mammal.

公开(公告)号：EP1053022A2

公开(公告)日：2000-11-22

申请号：EP99903556.1

申请日：1999-02-03

申请人： Inex Pharmaceuticals Corp.

发明人： MACLACHLAN, Ian ,  GRAHAM, Roger, W. ,  BUCHKOWSKY, Susan, S.

IPC分类号： A61K48/00

CPC分类号： C12N15/88 ,  A61K9/127 ,  A61K31/382 ,  A61K31/522 ,  A61K31/675 ,  A61K31/70 ,  A61K38/208 ,  A61K38/45 ,  A61K38/47 ,  A61K38/50 ,  A61K38/51 ,  A61K45/06 ,  A61K48/00 ,  Y10S977/804 ,  A61K2300/00

摘要： The present invention relates to methods and compositions for sensitizing a cell to a compound such as a prodrug.